UniProt:Q14997 PSME4

chain
  • chain:1-1843
checksum 2D2C3A594E4FA4E7
comment
  • FUNCTION Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.SUBUNIT Homodimer. Interacts with the 20S and 26S proteasomes. Component of the spermatoproteasome, a form of the proteasome specifically found in testis.INTERACTION Found in nuclear foci following treatment with ionizing radiation, but not with ultraviolet irradiation or H(2)O(2).ALTERNATIVE PRODUCTS The bromodomain-like (BRDL) region specifically recognizes and binds acetylated histones.SIMILARITY Belongs to the BLM10 family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 244147
description
  • recommendedName: Proteasome activator complex subunit 4 alternativeName: fullName evidence="8"Proteasome activator PA200 alternativeName: fullName evidence="8"Protein BLM10 homolog shortName evidence="8"Blm10 shortName evidence="8"hBlm10
displayName UniProt:Q14997 PSME4
geneName
  • PSME4
  • BLM10
  • KIAA0077
identifier Q14997
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Cytoplasm
  • Developmental protein
  • Differentiation
  • DNA damage
  • DNA repair
  • Nucleus
  • Phosphoprotein
  • Proteasome
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Spermatogenesis
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • PSME4
otherIdentifier
  • 11717864_a_at
  • 11717865_at
  • 11717866_s_at
  • 11751884_s_at
  • 11751885_x_at
  • 11755120_a_at
  • 16897560
  • 212219_PM_at
  • 212219_at
  • 212220_PM_at
  • 212220_at
  • 212222_PM_at
  • 212222_at
  • 23198
  • 2553269
  • 2553270
  • 2553271
  • 2553281
  • 2553283
  • 2553284
  • 2553285
  • 2553286
  • 2553288
  • 2553289
  • 2553290
  • 2553293
  • 2553294
  • 2553295
  • 2553296
  • 2553297
  • 2553298
  • 2553299
  • 2553300
  • 2553301
  • 2553302
  • 2553303
  • 2553304
  • 2553306
  • 2553307
  • 2553308
  • 2553309
  • 2553310
  • 2553311
  • 2553312
  • 2553313
  • 2553314
  • 2553315
  • 2553316
  • 2553317
  • 2553318
  • 2553319
  • 2553320
  • 2553321
  • 2553325
  • 2553326
  • 2553328
  • 2553329
  • 2553330
  • 2553331
  • 2553332
  • 2553333
  • 2553334
  • 2553335
  • 2553336
  • 2553338
  • 2553339
  • 2553340
  • 2553341
  • 2553343
  • 2553344
  • 2553345
  • 2553346
  • 2553347
  • 2553348
  • 2553349
  • 2553352
  • 2553355
  • 2553356
  • 2553357
  • 2553358
  • 2553366
  • 2553367
  • 36978_at
  • 50785_at
  • 8052149
  • A_23_P79628
  • A_33_P3243997
  • A_33_P3361472
  • D38521_at
  • GE57189
  • GO:0000502
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005737
  • GO:0005829
  • GO:0006281
  • GO:0006325
  • GO:0006974
  • GO:0007283
  • GO:0010499
  • GO:0016504
  • GO:0016607
  • GO:0022414
  • GO:0030154
  • GO:0035092
  • GO:0070577
  • GO:0070628
  • GO:0098772
  • GO:1990111
  • HMNXSV003000039
  • HMNXSV003009591
  • Hs.112396.0.S1_3p_at
  • Hs.112396.0.S2_3p_at
  • Hs.112396.0.S3_3p_at
  • ILMN_1763540
  • PH_hs_0040855
  • TC02001848.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • PSME4_HUMAN
  • Q1XBG4
  • Q1XBG5
  • Q1XBG6
  • Q2M1Z0
  • Q6IPR2
  • Q86XF8
sequenceLength 1843
species [Species:48887] Homo sapiens
stId uniprot:Q14997
url http://purl.uniprot.org/uniprot/Q14997

Referrals

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