Reactome | UniProt:Q14764 MVP

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UniProt:Q14764 MVP Show undefined attributes

chain	initiator methionine:1 chain:2-893
checksum	6FEE5545B0A3FE65
comment	FUNCTION Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.SUBUNIT The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or more vault RNAs (vRNAs). Interacts with TEP1. Interacts with PTEN and activated MAPK1. The phosphorylated protein interacts with the SH2 domains of PTPN11 and SRC. Interacts with APEX1. May interact with ZNF540.INTERACTION 5% found in the nuclear pore complex (PubMed:15133037). Translocates from the nucleus to the cytoplasm upon EGF treatment (PubMed:16441665).TISSUE SPECIFICITY Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells.INDUCTION Up-regulated by IFNG/IFN-gamma.DOMAIN MVP 3 mediates interaction with PTEN.DOMAIN MVP 4 mediates interaction with PARP4.PTM Phosphorylated on Tyr residues after EGF stimulation.PTM Dephosphorylated by PTPN11.
crossReference	[DatabaseIdentifier:12402375] RefSeq:NP_001280134.1 [DatabaseIdentifier:12402376] RefSeq:NP_005106.2 [DatabaseIdentifier:12402377] RefSeq:NP_059447.2 [DatabaseIdentifier:12402374] RefSeq:NP_001280133.1 [DatabaseIdentifier:12282177] Pharos - Targets:Q14764 [DatabaseIdentifier:12239817] PRO:Q14764 [DatabaseIdentifier:12156162] PDB:9MXH [DatabaseIdentifier:12156161] PDB:1Y7X [DatabaseIdentifier:12156160] PDB:9MXJ [DatabaseIdentifier:12156158] PDB:9R86 [DatabaseIdentifier:12156156] PDB:9R87 [DatabaseIdentifier:12140649] PDB:9BW7 [DatabaseIdentifier:12156159] PDB:9BW5 [DatabaseIdentifier:12140648] PDB:9BW6 [DatabaseIdentifier:12156157] PDB:9MXV [DatabaseIdentifier:12121855] OpenTargets:ENSG00000013364 [DatabaseIdentifier:11837360] HPA:ENSG00000013364-MVP [DatabaseIdentifier:11799754] GlyGen:Q14764 [DatabaseIdentifier:11784261] GeneCards:MVP [DatabaseIdentifier:11714818] ENSEMBL:ENST00000395353 [DatabaseIdentifier:11714817] ENSEMBL:ENST00000357402 [DatabaseIdentifier:11592119] ENSEMBL:ENSP00000378760 [DatabaseIdentifier:11592118] ENSEMBL:ENSP00000349977 [DatabaseIdentifier:11487356] ENSEMBL:ENSG00000013364
databaseName	UniProt
dbId	59723
description	recommendedName: Major vault protein shortName: MVP alternativeName: Lung resistance-related protein
displayName	UniProt:Q14764 MVP
geneName	MVP LRP
identifier	Q14764
isSequenceChanged	false
keyword	3D-structure Acetylation Cytoplasm Direct protein sequencing Isopeptide bond mRNA transport Nuclear pore complex Nucleus Phosphoprotein Protein transport Proteomics identification Reference proteome Repeat Ribonucleoprotein Translocation Transport Ubl conjugation
modified	[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType	Protein
name	MVP
otherIdentifier	11716135_a_at 11749978_a_at 16817692 202180_PM_s_at 202180_s_at 3655716 3655724 3655725 3655726 3655727 3655728 3655729 3655730 3655731 3655732 3655733 3655734 3655735 3655736 3655737 3655738 3655739 3655740 3655741 3655743 3655744 3655745 3655746 3655747 3655748 3655749 3655750 38064_at 7994659 9961 A_23_P88819 A_33_P3294608 GE60057 GO:0005515 GO:0005576 GO:0005634 GO:0005643 GO:0005737 GO:0005829 GO:0005856 GO:0008283 GO:0015031 GO:0016020 GO:0019901 GO:0019903 GO:0031953 GO:0034774 GO:0038127 GO:0042059 GO:0042802 GO:0048471 GO:0051028 GO:0051604 GO:0061099 GO:0070062 GO:0072376 GO:1904813 GO:1990904 HMNXSV003009533 ILMN_1803277 ILMN_2344373 PH_hs_0004640 TC16002071.hg X79882_at g9665254_3p_s_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-6803290] MVP [secretory granule lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6806474] MVP [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6803325] MVP [ficolin-1-rich granule lumen] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12746295] UCSC:Q14764 MVP [ReferenceDNASequence:12107516] OMIM:605088 MVP [ReferenceDNASequence:12066507] NCBI Gene:9961 MVP [ReferenceDNASequence:11982414] Monarch:9961 MVP [ReferenceDNASequence:11892311] KEGG:hsa:9961 MVP [ReferenceDNASequence:11815886] HGNC:7531 MVP [ReferenceDNASequence:11438246] dbSNP Gene:9961 MVP [ReferenceDNASequence:11408134] CTD Gene:9961 MVP [ReferenceDNASequence:11400990] COSMIC - genes:MVP MVP [ReferenceDNASequence:11352625] BioGPS Gene:9961 MVP [ReferenceDNASequence:ensembl:ENSG00000013364] ENSEMBL:ENSG00000013364 MVP
referenceTranscript	[ReferenceRNASequence:12584100] RefSeq:NM_001293204.1 MVP [ReferenceRNASequence:12584098] RefSeq:NM_017458.3 MVP [ReferenceRNASequence:12584099] RefSeq:NM_001293205.1 MVP [ReferenceRNASequence:12584101] RefSeq:NM_005115.4 MVP
schemaClass	ReferenceGeneProduct
secondaryIdentifier	MVP_HUMAN Q96BG4 Q9BPW6 Q9BQT1 Q9UBD1
sequenceLength	893
species	[Species:48887] Homo sapiens
stId	uniprot:Q14764
url	http://purl.uniprot.org/uniprot/Q14764

Referrals

(interactor)	[UndirectedInteraction:11220389] UniProt:Q9H0E2 <-> UniProt:Q14764 (IntAct) [UndirectedInteraction:11148493] UniProt:P13569 <-> UniProt:Q14764 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-6803290] MVP [secretory granule lumen] [EntityWithAccessionedSequence:R-HSA-6806474] MVP [extracellular region] [EntityWithAccessionedSequence:R-HSA-6803325] MVP [ficolin-1-rich granule lumen]