Reactome | UniProt:Q14515 SPARCL1

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UniProt:Q14515 SPARCL1 Show undefined attributes

chain	signal peptide:1-16 chain:17-664
checksum	0750B0080FDB96B6
comment	INTERACTION Highly expressed in lymph node, brain, heart, lung, skeletal muscle, ovary, small intestine, and colon, with lower levels in placenta, pancreas, testis, spleen, and thymus, and no expression in kidney, liver, and peripheral blood leukocytes.PTM N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.SIMILARITY Belongs to the SPARC family.
crossReference	[DatabaseIdentifier:12482425] RefSeq:NP_001121782.1 [DatabaseIdentifier:12482427] RefSeq:NP_001278905.1 [DatabaseIdentifier:12482428] RefSeq:NP_001278906.1 [DatabaseIdentifier:12482426] RefSeq:NP_004675.3 [DatabaseIdentifier:12293714] Pharos - Targets:Q14515 [DatabaseIdentifier:12276959] PRO:Q14515 [DatabaseIdentifier:12230648] PDB:7KBU [DatabaseIdentifier:12133548] OpenTargets:ENSG00000152583 [DatabaseIdentifier:11848857] HPA:ENSG00000152583-SPARCL1 [DatabaseIdentifier:11811649] GlyGen:Q14515 [DatabaseIdentifier:11795888] GeneCards:SPARCL1 [DatabaseIdentifier:11770295] ENSEMBL:ENST00000282470 [DatabaseIdentifier:11770294] ENSEMBL:ENST00000418378 [DatabaseIdentifier:11770296] ENSEMBL:ENST00000503414 [DatabaseIdentifier:11647597] ENSEMBL:ENSP00000422903 [DatabaseIdentifier:11647596] ENSEMBL:ENSP00000282470 [DatabaseIdentifier:11647595] ENSEMBL:ENSP00000414856 [DatabaseIdentifier:11525674] ENSEMBL:ENSG00000152583
databaseName	UniProt
dbId	64976
description	recommendedName: SPARC-like protein 1 alternativeName: High endothelial venule protein shortName: Hevin alternativeName: MAST 9
displayName	UniProt:Q14515 SPARCL1
geneName	SPARCL1
identifier	Q14515
isSequenceChanged	false
keyword	3D-structure Alternative splicing Calcium Disulfide bond Extracellular matrix Glycoprotein Metal-binding Phosphoprotein Proteomics identification Reference proteome Secreted Signal
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	SPARCL1
otherIdentifier	11725023_a_at 11730298_a_at 11752251_a_at 16977833 200795_PM_at 200795_at 2777118 2777119 2777124 2777125 2777126 2777131 2777132 2777133 2777136 2777137 2777138 2777139 2777140 2777141 2777142 2777143 2777144 2777146 2777147 2777148 2777150 2777154 2777159 2777160 2777161 36627_at 8101659 8404 A_23_P113351 GE81428 GO:0005509 GO:0005515 GO:0005518 GO:0005576 GO:0005615 GO:0005788 GO:0007165 GO:0030312 GO:0031012 GO:0046872 GO:0050807 GO:0050840 GO:0062023 GO:0098978 GO:0099560 HMNXSV003035923 ILMN_1795251 ILMN_1916651 ILMN_2218208 PH_hs_0004328 TC04001366.hg TC04002623.hg X86693_at g4758521_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-8957059] p-SPARCL1 [endoplasmic reticulum lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8956757] SPARCL1 [endoplasmic reticulum lumen] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12770497] UCSC:Q14515 SPARCL1 [ReferenceDNASequence:12117802] OMIM:606041 SPARCL1 [ReferenceDNASequence:12103327] NCBI Gene:8404 SPARCL1 [ReferenceDNASequence:12019234] Monarch:8404 SPARCL1 [ReferenceDNASequence:11925734] KEGG:hsa:8404 SPARCL1 [ReferenceDNASequence:11827593] HGNC:11220 SPARCL1 [ReferenceDNASequence:11441980] dbSNP Gene:8404 SPARCL1 [ReferenceDNASequence:11424963] CTD Gene:8404 SPARCL1 [ReferenceDNASequence:11404286] COSMIC - genes:SPARCL1 SPARCL1 [ReferenceDNASequence:11389445] BioGPS Gene:8404 SPARCL1 [ReferenceDNASequence:ensembl:ENSG00000152583] ENSEMBL:ENSG00000152583 SPARCL1
referenceTranscript	[ReferenceRNASequence:12663891] RefSeq:NM_001291976.2 SPARCL1 [ReferenceRNASequence:12663894] RefSeq:NM_001128310.3 SPARCL1 [ReferenceRNASequence:12663893] RefSeq:NM_004684.5 SPARCL1 [ReferenceRNASequence:12663892] RefSeq:NM_001291977.2 SPARCL1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	SPRL1_HUMAN B4E2Z0 E7ESU2 Q14800
sequenceLength	664
species	[Species:48887] Homo sapiens
stId	uniprot:Q14515
url	http://purl.uniprot.org/uniprot/Q14515

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-8957059] p-SPARCL1 [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-HSA-8956757] SPARCL1 [endoplasmic reticulum lumen]
(referenceSequence)	[ModifiedResidue:8956892] phosphorylated residue at unknown position

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