Reactome | UniProt:Q14393 GAS6

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UniProt:Q14393 GAS6 Show undefined attributes

chain	signal peptide:1-30 chain:31-678
checksum	BB6D8AB0F6C48EA9
comment	FUNCTION Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.FUNCTION (Microbial infection) Can bridge virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry (PubMed:21501828). Plays a role in Dengue cell entry by apoptotic mimicry (PubMed:23084921). Plays a role in Vaccinia virus cell entry by apoptotic mimicry (PubMed:21501828). Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry (PubMed:17005688).SUBUNIT Heterodimer and heterotetramer with AXL.INTERACTION Plasma. Isoform 1 and isoform 2 are widely expressed, isoform 1 being expressed at higher levels than isoform 2 in most tissues. Isoform 2 is the predominant form in spleen.PTM Proteolytically processed after secretion to yield a N-terminal 36 kDa protein and a C-terminal 50 kDa protein including the laminin G-like domains which activates AXL.PTM Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
created	[InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
crossReference	[DatabaseIdentifier:12278412] PRO:Q14393 [DatabaseIdentifier:12485620] RefSeq:NP_000811.1 [DatabaseIdentifier:12294765] Pharos - Targets:Q14393 [DatabaseIdentifier:11527096] ENSEMBL:ENSG00000183087 [DatabaseIdentifier:11649711] ENSEMBL:ENSP00000331831 [DatabaseIdentifier:11772410] ENSEMBL:ENST00000327773 [DatabaseIdentifier:11796935] GeneCards:GAS6 [DatabaseIdentifier:11812764] GlyGen:Q14393 [DatabaseIdentifier:11834251] HMDB Protein:HMDBP02012 [DatabaseIdentifier:11849903] HPA:ENSG00000183087-GAS6 [DatabaseIdentifier:12134603] OpenTargets:ENSG00000183087 [DatabaseIdentifier:12229396] PDB:5VXZ [DatabaseIdentifier:12235133] PDB:1H30 [DatabaseIdentifier:12229395] PDB:2C5D [DatabaseIdentifier:12229393] PDB:4RA0
databaseName	UniProt
dbId	147759
description	recommendedName: fullName evidence="20"Growth arrest-specific protein 6 shortName: GAS-6 alternativeName: AXL receptor tyrosine kinase ligand
displayName	UniProt:Q14393 GAS6
geneName	GAS6 AXLLG
identifier	Q14393
isSequenceChanged	false
keyword	3D-structure Alternative splicing Calcium Disulfide bond EGF-like domain Gamma-carboxyglutamic acid Glycoprotein Growth regulation Host-virus interaction Metal-binding Phosphoprotein Proteomics identification Reference proteome Repeat Secreted Signal
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	GAS6
otherIdentifier	11715551_s_at 11754440_s_at 1597_at 1598_PM_g_at 1598_g_at 16781285 202177_PM_at 202177_at 2621 3502837 3502838 3502839 3502856 3502857 3502858 3502859 3502866 3502867 3502868 3502870 3502871 3502877 3502882 3502883 3502884 3502885 3502886 3502887 3502888 3502889 3502893 3502896 3502897 3502903 3502904 3502905 3502906 3502907 3502908 3502909 3502910 3502911 3502912 3502913 3502914 3502915 3502916 3502917 37658_at 7970329 A_14_P125887 A_23_P146922 A_33_P3352085 GE57632 GO:0001764 GO:0001786 GO:0001934 GO:0001961 GO:0002376 GO:0003014 GO:0003104 GO:0005102 GO:0005509 GO:0005515 GO:0005576 GO:0005615 GO:0005737 GO:0005788 GO:0005796 GO:0006355 GO:0006468 GO:0006909 GO:0006915 GO:0007155 GO:0007165 GO:0007166 GO:0007167 GO:0007596 GO:0009267 GO:0010628 GO:0010804 GO:0016192 GO:0016477 GO:0019064 GO:0019079 GO:0030154 GO:0030198 GO:0030674 GO:0030971 GO:0031093 GO:0031100 GO:0031589 GO:0031669 GO:0032008 GO:0032148 GO:0032689 GO:0032692 GO:0032715 GO:0032720 GO:0032825 GO:0033028 GO:0033033 GO:0035457 GO:0035754 GO:0043027 GO:0043066 GO:0043277 GO:0044346 GO:0045860 GO:0045892 GO:0046718 GO:0046813 GO:0046827 GO:0046872 GO:0048018 GO:0048146 GO:0048856 GO:0048870 GO:0050766 GO:0051897 GO:0055085 GO:0060090 GO:0061024 GO:0070062 GO:0070168 GO:0070374 GO:0070588 GO:0071307 GO:0071333 GO:0071363 GO:0071466 GO:0072659 GO:0085029 GO:0097028 GO:0097241 GO:0098772 GO:1900142 GO:2000270 GO:2000352 GO:2000510 GO:2000533 GO:2000669 HMNXSV003017087 HMNXSV003048686 ILMN_1768260 ILMN_1779558 ILMN_1781614 ILMN_1784749 L13720_3p_s_at L13720_at PH_hs_0025635 TC13000899.hg g4557616_3p_s_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-391967] GAS6(39-678) [platelet alpha granule lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-429503] GAS6(39-678) [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8956720] GAS6 [endoplasmic reticulum lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8956905] p-GAS6 [endoplasmic reticulum lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-202768] 11xCbxE-GAS6(39-678) [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-163812] GAS6(31-678) [endoplasmic reticulum lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-163795] 11xCbxE-GAS6(31-678) [endoplasmic reticulum lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-163805] 11xCbxE-GAS6(31-678) [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-163840] GAS6(31-38) [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-163844] 11xCbxE-GAS6(39-678) [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9949458] 11xCbxE-GAS6(39-678) [endosome lumen] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000183087] ENSEMBL:ENSG00000183087 GAS6 [ReferenceDNASequence:12771012] UCSC:Q14393 GAS6 [ReferenceDNASequence:11390804] BioGPS Gene:2621 GAS6 [ReferenceDNASequence:11404361] COSMIC - genes:GAS6 GAS6 [ReferenceDNASequence:11426297] CTD Gene:2621 GAS6 [ReferenceDNASequence:11442064] dbSNP Gene:2621 GAS6 [ReferenceDNASequence:11828650] HGNC:4168 GAS6 [ReferenceDNASequence:11926999] KEGG:hsa:2621 GAS6 [ReferenceDNASequence:12020593] Monarch:2621 GAS6 [ReferenceDNASequence:12104686] NCBI Gene:2621 GAS6 [ReferenceDNASequence:12118767] OMIM:600441 GAS6
referenceTranscript	[ReferenceRNASequence:12667068] RefSeq:NM_000820.4 GAS6
schemaClass	ReferenceGeneProduct
secondaryIdentifier	GAS6_HUMAN B3KRQ7 B3KVL4 E9PBL7 Q6IMN1 Q7Z7N3
sequenceLength	678
species	[Species:48887] Homo sapiens
stId	uniprot:Q14393
url	http://purl.uniprot.org/uniprot/Q14393

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-391967] GAS6(39-678) [platelet alpha granule lumen] [EntityWithAccessionedSequence:R-HSA-429503] GAS6(39-678) [extracellular region] [EntityWithAccessionedSequence:R-HSA-8956720] GAS6 [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-HSA-8956905] p-GAS6 [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-HSA-202768] 11xCbxE-GAS6(39-678) [extracellular region] [EntityWithAccessionedSequence:R-HSA-163812] GAS6(31-678) [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-HSA-163795] 11xCbxE-GAS6(31-678) [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-HSA-163805] 11xCbxE-GAS6(31-678) [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-163840] GAS6(31-38) [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-163844] 11xCbxE-GAS6(39-678) [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-9949458] 11xCbxE-GAS6(39-678) [endosome lumen]
(referenceSequence)	[ModifiedResidue:8957063] phosphorylated residue at unknown position [ModifiedResidue:163826] L-gamma-carboxyglutamic acid at 74 [ModifiedResidue:163794] L-gamma-carboxyglutamic acid at 77 [ModifiedResidue:163811] L-gamma-carboxyglutamic acid at 55 [ModifiedResidue:163830] L-gamma-carboxyglutamic acid at 62 [ModifiedResidue:163796] L-gamma-carboxyglutamic acid at 64 [ModifiedResidue:163828] L-gamma-carboxyglutamic acid at 73 [ModifiedResidue:163797] L-gamma-carboxyglutamic acid at 84 [ModifiedResidue:163803] L-gamma-carboxyglutamic acid at 67 [ModifiedResidue:163832] L-gamma-carboxyglutamic acid at 54 [ModifiedResidue:163806] L-gamma-carboxyglutamic acid at 68 [ModifiedResidue:163807] L-gamma-carboxyglutamic acid at 80
(interactor)	[UndirectedInteraction:11171003] UniProt:Q14393 <-> UniProt:Q6PL45 (IntAct)