UniProt:Q14254 FLOT2

chain
  • initiator methionine:1
  • chain:2-428
checksum F690BFE0151D3BD7
comment
  • FUNCTION May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function.SUBUNIT Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2 (By similarity). Interacts with ECPAS.INTERACTION Membrane-associated protein of caveolae.TISSUE SPECIFICITY In skin, expressed in epidermis and epidermal appendages but not in dermis. Expressed in all layers of the epidermis except the basal layer. In hair follicles, expressed in the suprabasal layer but not the basal layer. Also expressed in melanoma and carcinoma cell lines, fibroblasts and foreskin melanocytes.PTM ZDHHC5-catalyzed palmitoylation predominantly occurs at Cys-4. ZDHHC5-catalyzed palmitoylation may be required for the formation of higher-order complexes and for neurite outgrowth in cultured neural stem cells.SIMILARITY Belongs to the band 7/mec-2 family. Flotillin subfamily.SEQUENCE CAUTION Truncated N-terminus.
crossReference
databaseName UniProt
dbId 54912
description
  • recommendedName: Flotillin-2 alternativeName: Epidermal surface antigen shortName: ESA alternativeName: Membrane component chromosome 17 surface marker 1
displayName UniProt:Q14254 FLOT2
geneName
  • FLOT2
  • ESA1
  • M17S1
identifier Q14254
isSequenceChanged false
keyword
  • Cell adhesion
  • Cell membrane
  • Endosome
  • Lipoprotein
  • Membrane
  • Myristate
  • Palmitate
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • FLOT2
otherIdentifier
  • 11716295_at
  • 11716296_at
  • 16842834
  • 201350_PM_at
  • 201350_at
  • 211299_PM_s_at
  • 211299_s_at
  • 2319
  • 32181_at
  • 3751124
  • 3751125
  • 3751126
  • 3751127
  • 3751128
  • 3751129
  • 3751130
  • 3751131
  • 3751132
  • 3751133
  • 3751134
  • 3751135
  • 3751136
  • 3751137
  • 3751138
  • 3751139
  • 3751140
  • 3751141
  • 3751142
  • 3751144
  • 3751147
  • 3751148
  • 3751149
  • 3751150
  • 3751155
  • 3751156
  • 3751157
  • 52561_s_at
  • 8013788
  • A_23_P55319
  • A_24_P253818
  • GE61554
  • GE87893
  • GO:0001931
  • GO:0002020
  • GO:0002080
  • GO:0005515
  • GO:0005768
  • GO:0005856
  • GO:0005886
  • GO:0005901
  • GO:0005912
  • GO:0005925
  • GO:0007018
  • GO:0007155
  • GO:0008544
  • GO:0010629
  • GO:0016020
  • GO:0016323
  • GO:0016600
  • GO:0022409
  • GO:0030027
  • GO:0030139
  • GO:0030864
  • GO:0031410
  • GO:0031982
  • GO:0032839
  • GO:0043123
  • GO:0043226
  • GO:0044291
  • GO:0044860
  • GO:0045121
  • GO:0045661
  • GO:0048471
  • GO:0048856
  • GO:0050821
  • GO:0070062
  • GO:0072659
  • GO:0098937
  • GO:0098978
  • GO:0099072
  • GO:1902992
  • GO:1903905
  • HMNXSV003044759
  • ILMN_1726222
  • ILMN_1790781
  • M60922_at
  • PH_hs_0022019
  • TC17001311.hg
  • g13277549_3p_a_at
  • g4758393_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • FLOT2_HUMAN
sequenceLength 428
species [Species:48887] Homo sapiens
stId uniprot:Q14254
url http://purl.uniprot.org/uniprot/Q14254
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