Reactome | UniProt:Q14160 SCRIB

chain	chain:1-1655
checksum	578827D6C352A4FC
comment	FUNCTION Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672).SUBUNIT Interacts with UBE3A (PubMed:11027293). Interacts with PAK1 and PAK2 (PubMed:18716323). Interacts (via PDZ domains) with VANGL2 (By similarity). Interacts (via PDZ domains) with LPP and TRIP6; the interaction is direct (PubMed:15649318, PubMed:16137684). Interacts (via PDZ domains) with TJP2 (PubMed:15975580). Interacts (via PDZ domains) with APC; may mediate APC targeting to adherens junctions of epithelial cells (PubMed:16611247). Interacts (via PDZ domains) with TSHR; regulates TSHR trafficking and function (PubMed:15775968). Interacts with ARHGEF7 and GIT1; interacts directly with ARHGEF7 (PubMed:15182672). Interacts with CTNNB1 (By similarity). Interacts with MAPK12 (By similarity). Interacts (via PDZ domains 1 and 3) with MCC (PubMed:19555689, PubMed:22480440). Interacts with DLG5 (PubMed:28169360). Interacts with STK4/MST1 and LATS1 in the presence of DLG5 (PubMed:28169360). Interacts (via PDZ domain 3) with CRTAM (via PDZ-binding motif); the interaction promotes CRTAM and SCRIB polarization in a subset of CD4+ T-cells (By similarity). Interacts with YES1, when YES1 is in a closed conformation; the interaction facilitates YES1 autophosphorylation (PubMed:33730553). Interacts (via PDZ domains) with VIM; the interaction protects SCRIB from proteasomal degradation and facilitates SCRIB localization to intermediate filaments, the interaction is reduced by cell contact inhibition (PubMed:19386766).SUBUNIT (Microbial infection) Interacts (via PDZ3) with tick-borne encephalitis virus RNA-directed RNA polymerase NS5 (via C-terminus); this interaction targets viral NS5 to the cell membrane periphery and nucleus and prevents STAT1 phosphorylation, and thus, the activation of the JAK-STAT signaling pathway.SUBUNIT (Microbial infection) Interacts with HPV E6.SUBUNIT (Microbial infection) Interacts with influenza A virus protein NS1; the interaction results in the translocation of SCRIB from the cell membrane to perinuclear puncta.INTERACTION Targeting to cell-cell junctions which is CDH1-dependent is required for the pro-apoptotic activity. In a subset of CD4+ T-cells, colocalizes with CRTAM at the immunological synapse during the late phase of T-cell activation (By similarity). Localized to small puncta throughout the cytoplasm and cell membrane when in the presence of SNAIL1 (By similarity). Localized along the length of perinuclear emanating vimentin bundles and at vimentin-positive fibrils at the cell periphery (PubMed:19386766). Localized to the lateral plasma membrane during the establishment and maturation of cell-cell contacts (PubMed:19386766).ALTERNATIVE PRODUCTS Expressed in kidney, skeletal muscles, liver, lung, breast, intestine, placenta and skin mainly in epithelial cells (at protein level).PTM Ubiquitinated; targeted for UBE3A-dependent multiubiquitination in the presence of high-risk HPV E6 proteins and degraded.PTM Palmitoylated (PubMed:27380321). Could be depalmitoylated by LYPLA1 and/or LYPLA2 (PubMed:27380321). Palmitoylation of SCRIB by ZDHHC7 is required for its localization to cell-cell junctions, function in the establishement of epithelial cell polarity and the regulation of downstream signaling pathways important for epithelial cell differentiation (PubMed:27380321).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the LAP (LRR and PDZ) protein family.
created	[InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
crossReference	[DatabaseIdentifier:11523056] ENSEMBL:ENSG00000274287 [DatabaseIdentifier:12476122] RefSeq:NP_874365.3 [DatabaseIdentifier:12476121] RefSeq:NP_056171.3 [DatabaseIdentifier:12291150] Pharos - Targets:Q14160 [DatabaseIdentifier:12273852] PRO:Q14160 [DatabaseIdentifier:12216891] PDB:6MS1 [DatabaseIdentifier:12216903] PDB:7QTU [DatabaseIdentifier:12216911] PDB:7QTO [DatabaseIdentifier:12216893] PDB:7QSB [DatabaseIdentifier:12216907] PDB:4WYU [DatabaseIdentifier:12216892] PDB:7QSA [DatabaseIdentifier:12216900] PDB:8CD3 [DatabaseIdentifier:12203649] PDB:6MTV [DatabaseIdentifier:12216902] PDB:7QRS [DatabaseIdentifier:12216890] PDB:5VWK [DatabaseIdentifier:12216904] PDB:7QS8 [DatabaseIdentifier:12216909] PDB:7QTP [DatabaseIdentifier:12216899] PDB:8B82 [DatabaseIdentifier:12207692] PDB:6MYE [DatabaseIdentifier:12167080] PDB:6XA6 [DatabaseIdentifier:12216906] PDB:7QRT [DatabaseIdentifier:12216912] PDB:6ESP [DatabaseIdentifier:12216901] PDB:7JO7 [DatabaseIdentifier:12216889] PDB:5VWI [DatabaseIdentifier:12216391] PDB:8BIA [DatabaseIdentifier:12167075] PDB:6XA7 [DatabaseIdentifier:12216897] PDB:6EEY [DatabaseIdentifier:12167074] PDB:6XA8 [DatabaseIdentifier:12216390] PDB:8BJ0 [DatabaseIdentifier:12216896] PDB:1UJU [DatabaseIdentifier:12216908] PDB:1WHA [DatabaseIdentifier:12152582] PDB:8B87 [DatabaseIdentifier:12216914] PDB:6MYF [DatabaseIdentifier:12203650] PDB:6MTU [DatabaseIdentifier:12216898] PDB:7QS9 [DatabaseIdentifier:12152586] PDB:8B9T [DatabaseIdentifier:12216895] PDB:5VWC [DatabaseIdentifier:12216905] PDB:4WYT [DatabaseIdentifier:12216910] PDB:2W4F [DatabaseIdentifier:12216913] PDB:8B8O [DatabaseIdentifier:12216894] PDB:1X5Q [DatabaseIdentifier:12130954] OpenTargets:ENSG00000180900 [DatabaseIdentifier:11846297] HPA:ENSG00000180900-SCRIB [DatabaseIdentifier:11809314] GlyGen:Q14160 [DatabaseIdentifier:11782962] GeneCards:SCRIB [DatabaseIdentifier:11766174] ENSEMBL:ENST00000612204 [DatabaseIdentifier:11766170] ENSEMBL:ENST00000611528 [DatabaseIdentifier:11766172] ENSEMBL:ENST00000377533 [DatabaseIdentifier:11766169] ENSEMBL:ENST00000356994 [DatabaseIdentifier:11766171] ENSEMBL:ENST00000320476 [DatabaseIdentifier:11766173] ENSEMBL:ENST00000622455 [DatabaseIdentifier:11643472] ENSEMBL:ENSP00000349486 [DatabaseIdentifier:11643470] ENSEMBL:ENSP00000322938 [DatabaseIdentifier:11643473] ENSEMBL:ENSP00000484041 [DatabaseIdentifier:11643471] ENSEMBL:ENSP00000366756 [DatabaseIdentifier:11643474] ENSEMBL:ENSP00000479898 [DatabaseIdentifier:11643475] ENSEMBL:ENSP00000482406 [DatabaseIdentifier:11523057] ENSEMBL:ENSG00000180900
databaseName	UniProt
dbId	149564
description	recommendedName: fullName evidence="31"Protein scribble homolog shortName: Scribble shortName: hScrib alternativeName: Protein LAP4
displayName	UniProt:Q14160 SCRIB
geneName	SCRIB CRIB1 KIAA0147 LAP4 SCRB1 VARTUL
identifier	Q14160
isSequenceChanged	false
keyword	3D-structure Alternative splicing Cell junction Cell membrane Cell projection Coiled coil Cytoplasm Developmental protein Differentiation Disease variant Leucine-rich repeat Lipoprotein Membrane Palmitate Phosphoprotein Proteomics identification Reference proteome Repeat Synapse Ubl conjugation
modified	[InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType	Protein
name	SCRIB
otherIdentifier	11721210_a_at 11721211_x_at 11744785_x_at 17082263 212556_PM_at 212556_at 23513 3157752 3157753 3157754 3157755 3157756 3157757 3157758 3157759 3157760 3157761 3157762 3157763 3157764 3157765 3157766 3157767 3157768 3157769 3157770 3157771 3157772 3157774 3157776 3157777 3157778 3157781 3157782 3157783 3157784 3157785 3157786 3157787 3157788 3157790 3157791 3157792 3157794 3157795 3157796 3157797 3157798 3157800 3157801 3157802 3157803 3157804 3157805 3157806 3157807 3157808 3157809 3157810 3157811 3157812 3157813 3157814 3157816 34743_at 8153497 81576_at A_23_P159039 D63481_at GO:0001768 GO:0001772 GO:0001843 GO:0001921 GO:0002093 GO:0005515 GO:0005654 GO:0005737 GO:0005886 GO:0005911 GO:0005912 GO:0007163 GO:0008104 GO:0008283 GO:0010669 GO:0010718 GO:0014069 GO:0016020 GO:0016080 GO:0016192 GO:0016323 GO:0016331 GO:0016477 GO:0019901 GO:0021747 GO:0030010 GO:0030027 GO:0030054 GO:0030154 GO:0030859 GO:0031252 GO:0032729 GO:0034750 GO:0035088 GO:0035089 GO:0035591 GO:0035748 GO:0036342 GO:0042060 GO:0042734 GO:0042995 GO:0043065 GO:0043113 GO:0043226 GO:0043615 GO:0044291 GO:0045197 GO:0045202 GO:0045211 GO:0045296 GO:0045930 GO:0046007 GO:0048488 GO:0048856 GO:0048870 GO:0050918 GO:0060088 GO:0060090 GO:0060122 GO:0060561 GO:0060603 GO:0070062 GO:0070161 GO:0071896 GO:0090630 GO:0098609 GO:0098793 GO:0098794 GO:0098887 GO:0098978 GO:0099003 GO:0099147 GO:0099149 HMNXSV003014612 Hs.239784.0.S1_3p_at Hs.239784.0.S1_3p_x_at ILMN_1695181 ILMN_1726516 ILMN_2324029 PH_hs_0020510 TC08001732.hg
physicalEntity	[EntityWithAccessionedSequence:R-HSA-4608858] SCRIB [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000180900] ENSEMBL:ENSG00000180900 SCRIB [ReferenceDNASequence:12769361] UCSC:Q14160 SCRIB [ReferenceDNASequence:12115460] OMIM:607733 SCRIB [ReferenceDNASequence:12100755] NCBI Gene:23513 SCRIB [ReferenceDNASequence:12016662] Monarch:23513 SCRIB [ReferenceDNASequence:11923354] KEGG:hsa:23513 SCRIB [ReferenceDNASequence:11814573] HGNC:30377 OSCRI [ReferenceDNASequence:11441668] dbSNP Gene:23513 SCRIB [ReferenceDNASequence:11421734] CTD Gene:23513 SCRIB [ReferenceDNASequence:11404014] COSMIC - genes:SCRIB SCRIB [ReferenceDNASequence:11386873] BioGPS Gene:23513 SCRIB
referenceTranscript	[ReferenceRNASequence:12657563] RefSeq:NM_015356.4 SCRIB [ReferenceRNASequence:12657562] RefSeq:NM_182706.4 SCRIB
schemaClass	ReferenceGeneProduct
secondaryIdentifier	SCRIB_HUMAN Q6P496 Q7Z5D1 Q8WWV8 Q96C69 Q96GG1
sequenceLength	1655
species	[Species:48887] Homo sapiens
stId	uniprot:Q14160
url	http://purl.uniprot.org/uniprot/Q14160

UniProt:Q14160 SCRIB Show undefined attributes

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