UniProt:Q14137 BOP1

chain
  • chain:1-746
checksum 49A97BE21B0EB3DD
comment
  • FUNCTION Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.SUBUNIT Component of the PeBoW complex, composed of BOP1, PES1 and WDR12 (PubMed:16043514, PubMed:16738141, PubMed:17189298, PubMed:17353269). The complex is held together by BOP1, which interacts with PES1 via its N-terminal domain and with WDR12 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome (By similarity). The PeBoW complex associates with DDX27, BOP1 interacts directly with DDX27 (PubMed:25825154).INTERACTION By MYC.SIMILARITY Belongs to the WD repeat BOP1/ERB1 family.
crossReference
databaseName UniProt
dbId 50924
description
  • recommendedName: fullName evidence="2"Ribosome biogenesis protein BOP1 alternativeName: fullName evidence="2"Block of proliferation 1 protein
displayName UniProt:Q14137 BOP1
geneName
  • BOP1
  • KIAA0124
identifier Q14137
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Ribosome biogenesis
  • rRNA processing
  • WD repeat
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • BOP1
otherIdentifier
  • 11757102_a_at
  • 17082507
  • 212563_PM_at
  • 212563_at
  • 216397_PM_s_at
  • 216397_s_at
  • 23246
  • 3158191
  • 3158192
  • 3158193
  • 3158194
  • 3158195
  • 3158196
  • 3158197
  • 3158198
  • 3158199
  • 3158200
  • 3158201
  • 3158202
  • 3158203
  • 3158204
  • 3158205
  • 3158206
  • 3158207
  • 3158208
  • 3158219
  • 3158220
  • 3158221
  • 3158222
  • 3158223
  • 3158224
  • 3158225
  • 3158226
  • 3158227
  • 3158228
  • 3158229
  • 3158230
  • 3158231
  • 3158232
  • 3158233
  • 3158234
  • 3158235
  • 3158236
  • 3158237
  • 3158238
  • 3158239
  • 3158240
  • 3158257
  • 3158258
  • 3158261
  • 3158269
  • 3158270
  • 3158271
  • 3158274
  • 3158275
  • 35615_at
  • 8153664
  • 8153678
  • A_23_P43800
  • D50914_at
  • GE57252
  • GO:0000027
  • GO:0000448
  • GO:0000460
  • GO:0000463
  • GO:0000466
  • GO:0003723
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005694
  • GO:0005730
  • GO:0006364
  • GO:0008283
  • GO:0030687
  • GO:0042254
  • GO:0042273
  • GO:0043021
  • GO:0051726
  • GO:0065003
  • GO:0070545
  • GO:1901796
  • GO:1990904
  • HMNXSV003026658
  • HMNXSV003051706
  • Hs.30736.0.S1_3p_at
  • Hs.30736.1.S1_3p_a_at
  • ILMN_1763955
  • PH_hs_0026681
  • TC08001743.hg
  • TC08001744.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • BOP1_HUMAN
  • Q969Z6
  • Q96IS8
  • Q96Q25
  • Q9BSA7
  • Q9BVM0
sequenceLength 746
species [Species:48887] Homo sapiens
stId uniprot:Q14137
url http://purl.uniprot.org/uniprot/Q14137
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