UniProt:Q14061 COX17

chain
  • initiator methionine:1
  • chain:2-63
checksum E97090F939E78276
comment
  • FUNCTION Copper metallochaperone involved in the assembly of cytochrome c oxidase (respiratory chain complex IV, CIV) (PubMed:15229189, PubMed:19393246, PubMed:31903891, PubMed:35750769). Binds two copper ions and delivers them to metallochaperones SCO1 and SCO2, which co-chaperone the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2), and to metallochaperone COX11 which relays the copper to the Cu(B) site on the cytochrome c oxidase subunit I (MT-CO1/COX1) (PubMed:15229189, PubMed:19393246, PubMed:35750769).SUBUNIT Interacts with COA1 (PubMed:22356826). Interacts with the chaperone CHCHD4; this is important for correct folding and the formation of disulfide bonds that stabilize the structure (PubMed:21059946).INTERACTION Ubiquitous.PTM Acetylation by KAT8 promotes assembly of the mitochondrial respiratory chain complex IV (CIV).SIMILARITY Belongs to the COX17 family.
crossReference
databaseName UniProt
dbId 52614
description
  • recommendedName: Cytochrome c oxidase copper chaperone
displayName UniProt:Q14061 COX17
geneName
  • COX17
identifier Q14061
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Chaperone
  • Copper
  • Cytochrome c-type biogenesis
  • Cytoplasm
  • Disulfide bond
  • Metal-binding
  • Mitochondrion
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • COX17
otherIdentifier
  • 10063
  • 11757627_at
  • 1558346_PM_at
  • 1558346_at
  • 16957824
  • 203880_PM_at
  • 203880_at
  • 2690969
  • 2690970
  • 2690974
  • 2690978
  • 2690980
  • 2690981
  • 2690982
  • 2690983
  • 2690984
  • 2690985
  • 2690986
  • 2690987
  • 2690988
  • 2690990
  • 2690991
  • 2690992
  • 2690994
  • 3488593
  • 40427_at
  • 62001_at
  • 7968972
  • 8089795
  • A_23_P144244
  • A_23_P65157
  • GE57799
  • GE86319
  • GO:0005507
  • GO:0005515
  • GO:0005737
  • GO:0005739
  • GO:0005758
  • GO:0006091
  • GO:0006825
  • GO:0007005
  • GO:0007507
  • GO:0008047
  • GO:0008284
  • GO:0016531
  • GO:0033617
  • GO:0046872
  • GO:0048856
  • GO:0065003
  • GO:0098772
  • GO:1903136
  • GO:1904960
  • HMNXSV003033293
  • Hs2.350916.1.S1_3p_at
  • ILMN_2187718
  • L77701_at
  • PH_hs_0035365
  • TC03001686.hg
  • TC03003045.hg
  • TC03003046.hg
  • TC03003390.hg
  • g5031644_3p_at
  • p26209
  • p26210
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • COX17_HUMAN
  • B2R5D2
  • D3DN84
  • Q3MHD6
sequenceLength 63
species [Species:48887] Homo sapiens
stId uniprot:Q14061
url http://purl.uniprot.org/uniprot/Q14061
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