Reactome | UniProt:Q14004 CDK13

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UniProt:Q14004 CDK13 Show undefined attributes

chain	chain:1-1512
checksum	3CA54A3585A2943D
comment	FUNCTION Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef.CATALYTIC ACTIVITY [DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)SUBUNIT (Microbial infection) Interacts with human herpes virus 1 (HHV-1) transcriptional regulator ICP22.SUBUNIT Interacts with CCNL1 and CCNL2 (By similarity). Interacts with CCNK. Interacts with C1QBP.SUBUNIT (Microbial infection) Interacts with HIV-1 Tat.INTERACTION Expressed in fetal brain, liver, muscle and in adult brain. Also expressed in neuroblastoma and glioblastoma tumors.RNA EDITING Edited at about 88%.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
crossReference	[DatabaseIdentifier:12811875] ZINC - Substances:CDK13_HUMAN [DatabaseIdentifier:12817956] ZINC - World Drugs:CDK13_HUMAN [DatabaseIdentifier:12815220] ZINC target:Q14004 [DatabaseIdentifier:11523604] ENSEMBL:ENSG00000065883 [DatabaseIdentifier:11644326] ENSEMBL:ENSP00000181839 [DatabaseIdentifier:11644327] ENSEMBL:ENSP00000340557 [DatabaseIdentifier:11767025] ENSEMBL:ENST00000340829 [DatabaseIdentifier:11767026] ENSEMBL:ENST00000181839 [DatabaseIdentifier:11780277] Guide to Pharmacology - Targets:1966 [DatabaseIdentifier:11793855] GeneCards:CDK13 [DatabaseIdentifier:11809824] GlyGen:Q14004 [DatabaseIdentifier:11830718] HMDB Protein:HMDBP01268 [DatabaseIdentifier:11846845] HPA:ENSG00000065883-CDK13 [DatabaseIdentifier:11850410] IntEnz:2.7.11.23 [DatabaseIdentifier:12131506] OpenTargets:ENSG00000065883 [DatabaseIdentifier:12135852] Orphanet:CDK13 [DatabaseIdentifier:12204106] PDB:5EFQ [DatabaseIdentifier:12204107] PDB:7NXJ [DatabaseIdentifier:12274527] PRO:Q14004 [DatabaseIdentifier:12291697] Pharos - Targets:Q14004 [DatabaseIdentifier:12477401] RefSeq:NP_003709.3 [DatabaseIdentifier:12477402] RefSeq:NP_112557.2 [DatabaseIdentifier:12804231] ZINC - Biogenic:CDK13_HUMAN [DatabaseIdentifier:12806468] ZINC - Investigational:CDK13_HUMAN [DatabaseIdentifier:12809836] ZINC - Predictions - Purchasable:CDK13_HUMAN
databaseName	UniProt
dbId	69465
description	recommendedName: Cyclin-dependent kinase 13 ecNumber: 2.7.11.22 ecNumber: 2.7.11.23 alternativeName: CDC2-related protein kinase 5 alternativeName: Cell division cycle 2-like protein kinase 5 alternativeName: Cell division protein kinase 13 shortName: hCDK13 alternativeName: Cholinesterase-related cell division controller
displayName	UniProt:Q14004 CDK13
geneName	CDK13 CDC2L CDC2L5 CHED KIAA1791
identifier	Q14004
isSequenceChanged	false
keyword	3D-structure Acetylation Alternative splicing ATP-binding Disease variant Host-virus interaction Intellectual disability Isopeptide bond Kinase mRNA processing mRNA splicing Nucleotide-binding Nucleus Phosphoprotein Proteomics identification Reference proteome RNA editing Serine/threonine-protein kinase Transferase Ubl conjugation
modified	[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType	Protein
name	CDK13
otherIdentifier	11729002_a_at 11755318_s_at 11761825_x_at 17045404 1793_at 207318_PM_s_at 207318_s_at 207319_PM_s_at 207319_s_at 210965_3p_x_at 210965_PM_x_at 210965_x_at 228991_PM_at 228991_at 232266_3p_x_at 232266_PM_x_at 232266_x_at 2998543 2998544 2998545 2998546 2998547 2998548 2998549 2998550 2998551 2998552 2998553 2998554 2998560 2998561 2998562 2998563 2998564 2998565 2998566 2998567 2998568 2998572 2998573 2998574 2998575 2998576 2998577 2998588 2998590 2998591 2998595 2998598 2998599 2998600 2998606 2998608 2998609 2998610 2998611 2998612 2998613 2998614 2998615 2998616 2998617 2998618 2998619 2998621 2998622 2998623 2998624 2998625 2998626 2998627 41821_at 61726_at 62595_at 69895_at 71570_at 72951_at 8132417 84356_at 85249_at 8621 A_14_P128114 A_14_P132583 A_14_P138420 A_23_P215296 A_24_P178493 A_33_P3329149 A_33_P3329153 GE58090 GE63301 GE702010 GO:0000166 GO:0000307 GO:0000380 GO:0002945 GO:0003723 GO:0003824 GO:0004672 GO:0004674 GO:0004693 GO:0004707 GO:0005515 GO:0005524 GO:0005576 GO:0005615 GO:0005634 GO:0005654 GO:0005768 GO:0005769 GO:0005770 GO:0005794 GO:0005829 GO:0005901 GO:0005925 GO:0006355 GO:0006397 GO:0006468 GO:0007173 GO:0008024 GO:0008353 GO:0008380 GO:0009966 GO:0010759 GO:0016071 GO:0016192 GO:0016301 GO:0016607 GO:0016740 GO:0019901 GO:0019902 GO:0019908 GO:0030097 GO:0030332 GO:0032206 GO:0032872 GO:0032968 GO:0034198 GO:0045944 GO:0048856 GO:0051403 GO:0051493 GO:0051726 GO:0070849 GO:0072584 GO:0090170 GO:0106310 GO:0120041 GO:0140096 GO:1904813 GO:2000641 GO:2000737 HMNXSV003009600 Hs.36636.0.A1_3p_at Hs.59498.0.S2_3p_a_at ILMN_1778557 ILMN_2356068 M80629_at PH_hs_0024632 TC07000254.hg TC07002273.hg TC07002274.hg g12654860_3p_x_at g4502710_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-6797014] CDK13 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6801374] CDK13 [ficolin-1-rich granule lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6806442] CDK13 [extracellular region] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000065883] ENSEMBL:ENSG00000065883 CDK13 [ReferenceDNASequence:11387479] BioGPS Gene:8621 CDK13 [ReferenceDNASequence:11404085] COSMIC - genes:CDK13 CDK13 [ReferenceDNASequence:11422470] CTD Gene:8621 CDK13 [ReferenceDNASequence:11441743] dbSNP Gene:8621 CDK13 [ReferenceDNASequence:11825550] HGNC:1733 CDK13 [ReferenceDNASequence:11923908] KEGG:hsa:8621 CDK13 [ReferenceDNASequence:12017268] Monarch:8621 CDK13 [ReferenceDNASequence:12101361] NCBI Gene:8621 CDK13 [ReferenceDNASequence:12115960] OMIM:603309 CDK13 [ReferenceDNASequence:12769715] UCSC:Q14004 CDK13
referenceTranscript	[ReferenceRNASequence:12658909] RefSeq:NM_031267.3 CDK13 [ReferenceRNASequence:12658908] RefSeq:NM_003718.4 CDK13
schemaClass	ReferenceGeneProduct
secondaryIdentifier	CDK13_HUMAN Q53G78 Q6DKQ9 Q75MH4 Q75MH5 Q96JN4 Q9H4A0 Q9H4A1 Q9UDR4
sequenceLength	1512
species	[Species:48887] Homo sapiens
stId	uniprot:Q14004
url	http://purl.uniprot.org/uniprot/Q14004

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