Reactome | UniProt:Q13568 IRF5

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UniProt:Q13568 IRF5 Show undefined attributes

chain	chain:1-498
checksum	01B2ED95C28384E8
comment	FUNCTION Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 (PubMed:11303025, PubMed:15695821, PubMed:22412986, PubMed:25326418, PubMed:32433612). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (By similarity). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway (By similarity). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148).ACTIVITY REGULATION Maintained as a monomer in an autoinhibited state (PubMed:18836453, PubMed:22412986, PubMed:25326418). Phosphorylation and activation follow the following steps: innate adapter protein TASL recruits IRF5, thereby licensing IRF5 for phosphorylation by IKBKB (PubMed:32433612). Phosphorylated IRF5 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce IFNs (PubMed:25326418, PubMed:32433612).ACTIVITY REGULATION (Microbial infection) Activated upon coronavirus SARS-CoV-2 infection.SUBUNIT Homodimer, when phosphorylated (PubMed:18836453, PubMed:25326418). Interacts with TASL (via pLxIS motif); interaction takes place downstream of TLR7, TLR8 or TLR9, leading to its activation (PubMed:32433612). Interacts with MYD88 and TRAF6 (By similarity).INTERACTION Shuttles between the nucleus and the cytoplasm: upon activation by the TLR adapter MYD88 and subsequent phosphorylation, translocates to the nucleus.ALTERNATIVE PRODUCTS Phosphorylation of serine and threonine residues by IKBKB in a C-terminal autoinhibitory region, stimulates dimerization, transport into the nucleus, assembly with the coactivator CBP/EP300 and initiation of transcription.PTM 'Lys-63'-linked polyubiquitination by TRAF6 is required for activation.DISEASE Disease susceptibility is associated with variants affecting the gene represented in this entry.DISEASE Disease susceptibility is associated with variants affecting the gene represented in this entry.DISEASE Disease susceptibility is associated with variants affecting the gene represented in this entry.SIMILARITY Belongs to the IRF family.
crossReference	[DatabaseIdentifier:12442704] RefSeq:XP_011514461.1 [DatabaseIdentifier:12442708] RefSeq:NP_116032.1 [DatabaseIdentifier:12442706] RefSeq:XP_047276292.1 [DatabaseIdentifier:12442709] RefSeq:XP_006716037.1 [DatabaseIdentifier:12442702] RefSeq:XP_011514460.1 [DatabaseIdentifier:12442700] RefSeq:NP_001092097.2 [DatabaseIdentifier:12442699] RefSeq:XP_047276295.1 [DatabaseIdentifier:12442698] RefSeq:XP_011514462.1 [DatabaseIdentifier:12442697] RefSeq:NP_001092099.1 [DatabaseIdentifier:12442705] RefSeq:XP_047276294.1 [DatabaseIdentifier:12442711] RefSeq:NP_001351243.1 [DatabaseIdentifier:12442710] RefSeq:NP_001092100.1 [DatabaseIdentifier:12442703] RefSeq:XP_047276293.1 [DatabaseIdentifier:11506676] ENSEMBL:ENSG00000128604 [DatabaseIdentifier:11619985] ENSEMBL:ENSP00000419149 [DatabaseIdentifier:11619983] ENSEMBL:ENSP00000349770 [DatabaseIdentifier:11619986] ENSEMBL:ENSP00000419950 [DatabaseIdentifier:11619984] ENSEMBL:ENSP00000418534 [DatabaseIdentifier:11619982] ENSEMBL:ENSP00000385352 [DatabaseIdentifier:11619987] ENSEMBL:ENSP00000418037 [DatabaseIdentifier:11742681] ENSEMBL:ENST00000477535 [DatabaseIdentifier:11742683] ENSEMBL:ENST00000465603 [DatabaseIdentifier:11742684] ENSEMBL:ENST00000473745 [DatabaseIdentifier:11742686] ENSEMBL:ENST00000402030 [DatabaseIdentifier:11742682] ENSEMBL:ENST00000357234 [DatabaseIdentifier:11742685] ENSEMBL:ENST00000489702 [DatabaseIdentifier:11783449] GeneCards:IRF5 [DatabaseIdentifier:11799031] GlyGen:Q13568 [DatabaseIdentifier:11836559] HPA:ENSG00000128604-IRF5 [DatabaseIdentifier:12121034] OpenTargets:ENSG00000128604 [DatabaseIdentifier:12136004] Orphanet:IRF5 [DatabaseIdentifier:12152106] PDB:3DSH [DatabaseIdentifier:12259362] PRO:Q13568 [DatabaseIdentifier:12281368] Pharos - Targets:Q13568 [DatabaseIdentifier:12442701] RefSeq:XP_047276296.1 [DatabaseIdentifier:12442707] RefSeq:NP_001334857.1 [DatabaseIdentifier:12442712] RefSeq:NP_001229381.1
databaseName	UniProt
dbId	57483
description	recommendedName: fullName evidence="17"Interferon regulatory factor 5 shortName evidence="17"IRF-5
displayName	UniProt:Q13568 IRF5
geneName	IRF5
identifier	Q13568
isSequenceChanged	false
keyword	3D-structure Alternative splicing Antiviral defense Cytoplasm DNA-binding Immunity Inflammatory response Innate immunity Isopeptide bond Nucleus Phosphoprotein Proteomics identification Reference proteome Systemic lupus erythematosus Transcription Transcription regulation Ubl conjugation
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	IRF5
otherIdentifier	11726685_a_at 11726686_a_at 11726687_a_at 11746801_x_at 11752974_a_at 11762306_a_at 17051347 205468_PM_s_at 205468_s_at 205469_PM_s_at 205469_s_at 239412_PM_at 239412_at 3023247 3023248 3023249 3023250 3023251 3023252 3023253 3023254 3023255 3023256 3023257 3023258 3023259 3023260 3023261 3023262 3023263 3023264 36465_at 3663 477_at 478_g_at 8136045 A_14_P120116 A_23_P500271 A_24_P363609 GE59217 GO:0000785 GO:0000976 GO:0000978 GO:0000981 GO:0001228 GO:0002376 GO:0002720 GO:0003677 GO:0003700 GO:0005515 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0006355 GO:0006357 GO:0006954 GO:0019221 GO:0019901 GO:0032481 GO:0032727 GO:0032728 GO:0032735 GO:0042802 GO:0043065 GO:0043565 GO:0045087 GO:0045893 GO:0045944 GO:0051607 GO:0070431 GO:0071224 GO:0071225 GO:0098542 GO:0098586 GO:0120283 GO:1990837 HMNXSV003027868 Hs.232644.0.A1_3p_at Hs.54434.0.S1_3p_a_at ILMN_1670576 ILMN_2312606 PH_hs_0016421 TC07000789.hg U51127_at g4504726_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-1015676] IRF5 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9860271] p-S446-IRF5 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9860304] p-S446-IRF5 [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000128604] ENSEMBL:ENSG00000128604 IRF5 [ReferenceDNASequence:12760492] UCSC:Q13568 IRF5 [ReferenceDNASequence:11371919] BioGPS Gene:3663 IRF5 [ReferenceDNASequence:11402677] COSMIC - genes:IRF5 IRF5 [ReferenceDNASequence:11407108] CTD Gene:3663 IRF5 [ReferenceDNASequence:11440186] dbSNP Gene:3663 IRF5 [ReferenceDNASequence:11815066] HGNC:6120 IRF5 [ReferenceDNASequence:11909916] KEGG:hsa:3663 IRF5 [ReferenceDNASequence:12001708] Monarch:3663 IRF5 [ReferenceDNASequence:12085801] NCBI Gene:3663 IRF5 [ReferenceDNASequence:12106783] OMIM:607218 IRF5
referenceTranscript	[ReferenceRNASequence:12624271] RefSeq:NM_001098630.3 IRF5 [ReferenceRNASequence:12624266] RefSeq:NM_032643.5 IRF5 [ReferenceRNASequence:12624263] RefSeq:XM_047420336.1 IRF5 [ReferenceRNASequence:12624262] RefSeq:XM_011516160.2 IRF5 [ReferenceRNASequence:12624258] RefSeq:NM_001347928.2 IRF5 [ReferenceRNASequence:12624272] RefSeq:XM_047420340.1 IRF5 [ReferenceRNASequence:12624260] RefSeq:XM_047420338.1 IRF5 [ReferenceRNASequence:12624269] RefSeq:XM_011516158.4 IRF5 [ReferenceRNASequence:12624267] RefSeq:NM_001364314.2 IRF5 [ReferenceRNASequence:12624268] RefSeq:NM_001242452.3 IRF5 [ReferenceRNASequence:12624265] RefSeq:XM_047420337.1 IRF5 [ReferenceRNASequence:12624261] RefSeq:XM_047420339.1 IRF5 [ReferenceRNASequence:12624270] RefSeq:XM_011516159.4 IRF5 [ReferenceRNASequence:12624257] RefSeq:NM_001098629.3 IRF5 [ReferenceRNASequence:12624264] RefSeq:NM_001098627.4 IRF5 [ReferenceRNASequence:12624259] RefSeq:XM_006715974.3 IRF5
schemaClass	ReferenceGeneProduct
secondaryIdentifier	IRF5_HUMAN A4D1J8 A8DUA8 A8DUA9 E7EQ16 E7EW54 Q1A7B4 Q64GA9 Q64GB1 Q64GB2 Q6RCM8 Q9BQF0
sequenceLength	498
species	[Species:48887] Homo sapiens
stId	uniprot:Q13568
url	http://purl.uniprot.org/uniprot/Q13568

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-1015676] IRF5 [cytosol] [EntityWithAccessionedSequence:R-HSA-9860271] p-S446-IRF5 [cytosol] [EntityWithAccessionedSequence:R-HSA-9860304] p-S446-IRF5 [nucleoplasm]
(referenceSequence)	[ModifiedResidue:9860249] O-phospho-L-serine at 446
(interactor)	[UndirectedInteraction:11153843] UniProt:Q13263 <-> UniProt:Q13568 (IntAct) [UndirectedInteraction:11176751] UniProt:Q13568 <-> UniProt:Q04206 (IntAct) [UndirectedInteraction:11176753] UniProt:Q13568 <-> UniProt:Q13568 (IntAct) [UndirectedInteraction:11176753] UniProt:Q13568 <-> UniProt:Q13568 (IntAct) [UndirectedInteraction:11176755] UniProt:Q13568 <-> UniProt:Q92793 (IntAct) [UndirectedInteraction:11176757] UniProt:Q13568 <-> UniProt:O94986 (IntAct) [UndirectedInteraction:11176759] UniProt:Q13568 <-> UniProt:O43765 (IntAct) [UndirectedInteraction:11176761] UniProt:Q13568 <-> UniProt:Q7Z434 (IntAct) [UndirectedInteraction:11176763] UniProt:Q13568 <-> UniProt:Q8N697 (IntAct)