UniProt:Q13555 CAMK2G

chain
  • chain:1-558
checksum 7D61AB799B8F8CEB
comment
  • FUNCTION Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (PubMed:16690701). In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity).CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)ACTIVITY REGULATION Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a constitutively active form and confers to the kinase a Ca(2+)-independent activity.SUBUNIT CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other.INTERACTION Expressed in skeletal muscle.INDUCTION Activity is induced in skeletal muscle during exercise.DOMAIN The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization.PTM Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state.DISEASE The disease may be caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.SEQUENCE CAUTION Truncated N-terminus.
crossReference
databaseName UniProt
dbId 57909
description
  • recommendedName: Calcium/calmodulin-dependent protein kinase type II subunit gamma shortName: CaM kinase II subunit gamma shortName: CaMK-II subunit gamma ecNumber: 2.7.11.17
displayName UniProt:Q13555 CAMK2G
geneName
  • CAMK2G
  • CAMK
  • CAMK-II
  • CAMKG
identifier Q13555
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • ATP-binding
  • Calmodulin-binding
  • Developmental protein
  • Differentiation
  • Intellectual disability
  • Kinase
  • Membrane
  • Neurogenesis
  • Nucleotide-binding
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Sarcoplasmic reticulum
  • Serine/threonine-protein kinase
  • Transferase
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • CAMK2G
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • KCC2G_HUMAN
  • A0A0A0MS52
  • A0A0A0MT11
  • O00561
  • O15378
  • Q13279
  • Q13282
  • Q13556
  • Q5SQZ3
  • Q5SQZ4
  • Q5SWX4
  • Q7KYX5
  • Q8N4I3
  • Q8NIA4
sequenceLength 558
species [Species:48887] Homo sapiens
stId uniprot:Q13555
url http://purl.uniprot.org/uniprot/Q13555
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