UniProt:Q13478 IL18R1

chain
  • signal peptide:1-18
  • chain:19-541
checksum 7173DB9C7EA71D32
comment
  • FUNCTION Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B (PubMed:14528293, PubMed:25261253, PubMed:25500532, PubMed:37993714, PubMed:8626725). Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850). Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity).CATALYTIC ACTIVITY NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+)SUBUNIT Forms a ternary complex with IL18 and IL18RAP (PubMed:14528293, PubMed:25500532). Within this complex, IL18R1 is involved in ligand-binding and IL18RAP in signaling leading to NF-kappa-B and JNK activation (Probable). Interacts with SLC12A3 in peritoneal macrophages; this interaction is increased by IL18 treatment (By similarity).INTERACTION Highly expressed in leukocytes, spleen, lung. Also expressed, but at lower levels, in liver, small intestine, colon, prostate, thymus, placenta, and heart. Specifically coexpressed with IL18R1 in Th1 cells (PubMed:10653850, PubMed:10925275, PubMed:11046021).INDUCTION Induced by IL12/interleukin-12 in T-cells. Proposed to be a phenotypic marker for T-helper 1 (Th1) cells.DOMAIN The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.PTM N-glycosylated. N-linked glycosyl chains contribute to ligand recognition and intra-receptor interactions required for formation of an active ternary receptor complex.SIMILARITY Belongs to the interleukin-1 receptor family.
crossReference
databaseName UniProt
dbId 57463
description
  • recommendedName: Interleukin-18 receptor 1 shortName: IL-18R-1 shortName: IL-18R1 ecNumber evidence="4"3.2.2.6 alternativeName: CD218 antigen-like family member A alternativeName: CDw218a alternativeName: IL1 receptor-related protein shortName: IL-1Rrp shortName: IL1R-rp alternativeName: fullName evidence="14 15 16 17"Interleukin-18 receptor alpha shortName: IL-18R-alpha shortName evidence="14 15 16 17"IL-18Ralpha cdAntigenNameCD218a/cdAntigenName
displayName UniProt:Q13478 IL18R1
geneName
  • IL18R1
  • IL1RRP
identifier Q13478
isSequenceChanged false
keyword
  • 3D-structure
  • Direct protein sequencing
  • Disulfide bond
  • Glycoprotein
  • Hydrolase
  • Immunoglobulin domain
  • Inflammatory response
  • Membrane
  • NAD
  • Proteomics identification
  • Receptor
  • Reference proteome
  • Repeat
  • Signal
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • IL18R1
otherIdentifier
  • 11735275_at
  • 11735276_a_at
  • 16883715
  • 206618_PM_at
  • 206618_at
  • 2497083
  • 2497112
  • 2497114
  • 2497116
  • 2497118
  • 2497120
  • 2497121
  • 2497122
  • 2497124
  • 2497125
  • 2497126
  • 2497128
  • 2497131
  • 2497132
  • 2497134
  • 2497135
  • 2497136
  • 2497137
  • 2497139
  • 2497144
  • 2497145
  • 2497147
  • 2497148
  • 2497149
  • 2497150
  • 2497151
  • 2497152
  • 2497153
  • 2497154
  • 36377_at
  • 8044035
  • 85412_r_at
  • 8809
  • A_14_P113967
  • A_23_P39735
  • A_24_P208567
  • A_33_P3211666
  • A_33_P3251876
  • GE587846
  • GE62434
  • GE700545
  • GO:0002250
  • GO:0002376
  • GO:0004908
  • GO:0005515
  • GO:0005886
  • GO:0006355
  • GO:0006954
  • GO:0006955
  • GO:0007165
  • GO:0009986
  • GO:0016020
  • GO:0016787
  • GO:0019221
  • GO:0030101
  • GO:0030154
  • GO:0032729
  • GO:0035655
  • GO:0038023
  • GO:0042007
  • GO:0042008
  • GO:0045063
  • GO:0045092
  • GO:0051092
  • GO:0061809
  • GO:0120163
  • GO:1901224
  • GO:2000556
  • HMNXSV003025163
  • ILMN_1781700
  • PH_hs_0009687
  • TC02004995.hg
  • U43672_at
  • g4504654_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • IL18R_HUMAN
  • B2R9Y5
  • Q52LC9
sequenceLength 541
species [Species:48887] Homo sapiens
stId uniprot:Q13478
url http://purl.uniprot.org/uniprot/Q13478
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