UniProt:Q13443 ADAM9

chain
  • signal peptide:1-28
  • chain:29-819
checksum BC186641833137FF
comment
  • FUNCTION Metalloprotease that cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins.FUNCTION May act as alpha-secretase for amyloid precursor protein (APP).COFACTOR Binds 1 zinc ion per subunit.ACTIVITY REGULATION Synthesized as an inactive form which is proteolytically cleaved to generate an active enzyme. Processing at the upstream site is particularly important for activation of the proenzyme, whereas processing at the boundary between the pro-domain and the catalytic domain does not appear to be essential. Inhibited by hydroxamic acid-based inhibitors.SUBUNIT Interacts with SH3GL2 and SNX9 through its cytoplasmic tail (PubMed:10531379). Interacts with ITGA6.INTERACTION Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart.PTM Proteolytically cleaved in the trans-Golgi network before it reaches the plasma membrane to generate a mature protein. The removal of the pro-domain occurs via cleavage at two different sites. Processed most likely by a pro-protein convertase such as furin, at the boundary between the pro-domain and the catalytic domain. An additional upstream cleavage pro-protein convertase site (Arg-56/Glu-57) has an important role in the activation of ADAM9.PTM Phosphorylation is induced in vitro by phorbol-12-myristate-13-acetate (PMA).DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.CAUTION Has sometimes been referred to as ADAM-12.
crossReference
databaseName UniProt
dbId 49664
description
  • recommendedName: Disintegrin and metalloproteinase domain-containing protein 9 shortName: ADAM 9 ecNumber evidence="2"3.4.24.- alternativeName: Cellular disintegrin-related protein alternativeName: Meltrin-gamma alternativeName: Metalloprotease/disintegrin/cysteine-rich protein 9 alternativeName: Myeloma cell metalloproteinase
displayName UniProt:Q13443 ADAM9
geneName
  • ADAM9
  • KIAA0021
  • MCMP
  • MDC9
  • MLTNG
identifier Q13443
isSequenceChanged false
keyword
  • Alternative splicing
  • Cell membrane
  • Cone-rod dystrophy
  • Disulfide bond
  • Glycoprotein
  • Hydrolase
  • Membrane
  • Metal-binding
  • Metalloprotease
  • Phosphoprotein
  • Protease
  • Proteomics identification
  • Reference proteome
  • Secreted
  • Signal
  • Transmembrane
  • Transmembrane helix
  • Zinc
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • ADAM9
otherIdentifier
  • 11741960_a_at
  • 11747540_a_at
  • 11755796_a_at
  • 11755797_x_at
  • 1555326_PM_a_at
  • 1555326_a_at
  • 1570042_PM_a_at
  • 1570042_a_at
  • 17068170
  • 202381_PM_at
  • 202381_at
  • 3095003
  • 3095004
  • 3095010
  • 3095012
  • 3095013
  • 3095015
  • 3095016
  • 3095017
  • 3095018
  • 3095019
  • 3095020
  • 3095021
  • 3095022
  • 3095023
  • 3095024
  • 3095025
  • 3095026
  • 3095029
  • 3095031
  • 3095032
  • 3095039
  • 3095040
  • 3095041
  • 3095042
  • 3095044
  • 3095045
  • 3095047
  • 3095048
  • 3095050
  • 3095051
  • 3095052
  • 3095054
  • 3095055
  • 3095056
  • 3095058
  • 3095059
  • 34761_r_at
  • 8146000
  • 8754
  • A_14_P122599
  • A_23_P72643
  • A_32_P5168
  • A_32_P80678
  • A_33_P3340769
  • GE59148
  • GO:0004222
  • GO:0005080
  • GO:0005178
  • GO:0005515
  • GO:0005518
  • GO:0005576
  • GO:0005615
  • GO:0005886
  • GO:0005925
  • GO:0006508
  • GO:0006509
  • GO:0007155
  • GO:0007160
  • GO:0007179
  • GO:0007229
  • GO:0008233
  • GO:0008237
  • GO:0009897
  • GO:0009986
  • GO:0010042
  • GO:0016020
  • GO:0016477
  • GO:0016485
  • GO:0016787
  • GO:0017124
  • GO:0030154
  • GO:0030216
  • GO:0030335
  • GO:0031293
  • GO:0033627
  • GO:0033630
  • GO:0033631
  • GO:0034241
  • GO:0034612
  • GO:0042117
  • GO:0042542
  • GO:0042987
  • GO:0043236
  • GO:0043410
  • GO:0046872
  • GO:0048870
  • GO:0050714
  • GO:0051044
  • GO:0051384
  • GO:0051549
  • GO:0051592
  • GO:0070062
  • GO:0071222
  • GO:1902945
  • HMNXSV003027365
  • Hs2.130633.1.S1_3p_s_at
  • Hs2.2442.2.S1_3p_s_at
  • ILMN_1727524
  • PH_hs_0040856
  • TC08000298.hg
  • TC08001887.hg
  • U41766_s_at
  • g4501914_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • ADAM9_HUMAN
  • B7ZLN7
  • Q10718
  • Q8NFM6
sequenceLength 819
species [Species:48887] Homo sapiens
stId uniprot:Q13443
url http://purl.uniprot.org/uniprot/Q13443
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