Reactome | UniProt:Q13435 SF3B2

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UniProt:Q13435 SF3B2 Show undefined attributes

chain	chain:1-895
checksum	D372AFA679443AD6
comment	FUNCTION Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:12234937, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B2 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937, PubMed:27720643). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932).SUBUNIT Component of the 17S U2 SnRNP complex, a ribonucleoprotein complex that contains small nuclear RNA (snRNA) U2 and a number of specific proteins (PubMed:11991638, PubMed:12234937, PubMed:15146077, PubMed:32494006, PubMed:34822310, PubMed:36797247). Part of the SF3B subcomplex of the 17S U2 SnRNP complex (PubMed:12234937, PubMed:12738865, PubMed:27720643, PubMed:28541300). SF3B associates with the splicing subcomplex SF3A and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP) (PubMed:12234937). Within the SF3B complex, interacts directly with SF3B4 (PubMed:25737013). Found in a complex with PRMT9, SF3B2 and SF3B4 (PubMed:25737013). Interacts (Arg-508-methylated form) with SMN1 (via Tudor domain) (PubMed:25737013). Interacts with RBM7 (PubMed:27905398). Interacts with ERCC6 (PubMed:26030138). Component of the minor spliceosome (PubMed:15146077, PubMed:33509932). Within this complex, interacts with SCNM1 and CRIPT (PubMed:33509932).SUBUNIT (Microbial infection) Interacts with HIV-1 Vpr.INTERACTION Methylation at Arg-508 by PRMT9 is required for the interaction with SMN1.DISEASE The disease is caused by variants affecting the gene represented in this entry.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Contaminating sequence. Potential poly-A sequence.SEQUENCE CAUTION Truncated N-terminus.
crossReference	[DatabaseIdentifier:12152434] PDB:7ABH [DatabaseIdentifier:12444846] RefSeq:NP_006833.2 [DatabaseIdentifier:12282173] Pharos - Targets:Q13435 [DatabaseIdentifier:12260104] PRO:Q13435 [DatabaseIdentifier:12139756] PDB:8RM5 [DatabaseIdentifier:12156142] PDB:7ONB [DatabaseIdentifier:12145812] PDB:5Z56 [DatabaseIdentifier:12139754] PDB:8R0B [DatabaseIdentifier:12145810] PDB:8I0T [DatabaseIdentifier:12148381] PDB:5Z58 [DatabaseIdentifier:12145809] PDB:8I0S [DatabaseIdentifier:12139758] PDB:8R09 [DatabaseIdentifier:12139761] PDB:8H6J [DatabaseIdentifier:12139757] PDB:8QO9 [DatabaseIdentifier:12139755] PDB:8R08 [DatabaseIdentifier:12139759] PDB:8H6L [DatabaseIdentifier:12139751] PDB:8R0A [DatabaseIdentifier:12156143] PDB:7EVO [DatabaseIdentifier:12141230] PDB:8I0V [DatabaseIdentifier:12145811] PDB:5Z57 [DatabaseIdentifier:12148382] PDB:7DVQ [DatabaseIdentifier:12139762] PDB:8H6K [DatabaseIdentifier:12141229] PDB:8I0U [DatabaseIdentifier:12142436] PDB:7ABG [DatabaseIdentifier:12156137] PDB:7Q4P [DatabaseIdentifier:12145806] PDB:7ABI [DatabaseIdentifier:12155846] PDB:8Y7E [DatabaseIdentifier:12155844] PDB:7Q4O [DatabaseIdentifier:12155842] PDB:6Y5Q [DatabaseIdentifier:12145805] PDB:6FF4 [DatabaseIdentifier:12155847] PDB:6Y53 [DatabaseIdentifier:12156141] PDB:7Q3L [DatabaseIdentifier:12156139] PDB:7VPX [DatabaseIdentifier:12145803] PDB:7QTT [DatabaseIdentifier:12139746] PDB:8QXD [DatabaseIdentifier:12139744] PDB:6AHD [DatabaseIdentifier:11507642] ENSEMBL:ENSG00000087365 [DatabaseIdentifier:11621527] ENSEMBL:ENSP00000318861 [DatabaseIdentifier:11744226] ENSEMBL:ENST00000322535 [DatabaseIdentifier:11784257] GeneCards:SF3B2 [DatabaseIdentifier:11799751] GlyGen:Q13435 [DatabaseIdentifier:11837356] HPA:ENSG00000087365-SF3B2 [DatabaseIdentifier:12121849] OpenTargets:ENSG00000087365 [DatabaseIdentifier:12145808] PDB:8I0P [DatabaseIdentifier:12142015] PDB:8HK1 [DatabaseIdentifier:12145807] PDB:8I0R [DatabaseIdentifier:12139749] PDB:6QX9 [DatabaseIdentifier:12156140] PDB:6Y50 [DatabaseIdentifier:12156138] PDB:2DO5 [DatabaseIdentifier:12145802] PDB:6FF7 [DatabaseIdentifier:12139750] PDB:6AH0 [DatabaseIdentifier:12145804] PDB:8CH6 [DatabaseIdentifier:12139735] PDB:8QZS [DatabaseIdentifier:12139734] PDB:8H6E
databaseName	UniProt
dbId	71970
description	recommendedName: Splicing factor 3B subunit 2 alternativeName: Pre-mRNA-splicing factor SF3b 145 kDa subunit shortName: SF3b145 alternativeName: Spliceosome-associated protein 145 shortName: SAP 145
displayName	UniProt:Q13435 SF3B2
geneName	SF3B2 SAP145
identifier	Q13435
isSequenceChanged	false
keyword	3D-structure Acetylation Coiled coil Direct protein sequencing Disease variant Host-virus interaction Isopeptide bond Methylation mRNA processing mRNA splicing Nucleus Phosphoprotein Proteomics identification Reference proteome Spliceosome Ubl conjugation
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	SF3B2
otherIdentifier	10992 11715581_a_at 11715582_s_at 1558230_PM_at 1558230_at 16727238 200619_3p_at 200619_PM_at 200619_at 3335909 3335910 3335911 3335912 3335913 3335914 3335915 3335916 3335917 3335918 3335919 3335920 3335921 3335922 3335923 3335924 3335925 3335926 3335927 3335928 3335929 3335930 3335931 3335932 3335933 3335934 3335935 3335936 3335937 3335938 3335939 3335940 3335941 3335942 3335943 3335944 3335945 3335946 3335947 3335948 3335949 3335950 3335951 36973_at 7941511 A_14_P200307 A_23_P64083 A_33_P3702906 GE59142 GO:0000398 GO:0003723 GO:0005515 GO:0005634 GO:0005654 GO:0005681 GO:0005684 GO:0005686 GO:0005689 GO:0006397 GO:0008380 GO:0016071 GO:0016607 GO:0065003 GO:0071005 GO:0071011 GO:0071013 GO:1903241 HMNXSV003012917 HMNXSV003035957 Hs2.418477.1.S1_3p_at ILMN_1775939 PH_hs_0033158 PH_hs_0035094 TC11000652.hg TC11000653.hg U41371_at g5803154_3p_at g5803154_3p_s_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-71971] SF3B2 [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000087365] ENSEMBL:ENSG00000087365 SF3B2 [ReferenceDNASequence:12760889] UCSC:Q13435 SF3B2 [ReferenceDNASequence:11372765] BioGPS Gene:10992 SF3B2 [ReferenceDNASequence:11402803] COSMIC - genes:SF3B2 SF3B2 [ReferenceDNASequence:11408129] CTD Gene:10992 SF3B2 [ReferenceDNASequence:11440334] dbSNP Gene:10992 SF3B2 [ReferenceDNASequence:11815882] HGNC:10769 SF3B2 [ReferenceDNASequence:11910691] KEGG:hsa:10992 SF3B2 [ReferenceDNASequence:12002554] Monarch:10992 SF3B2 [ReferenceDNASequence:12086647] NCBI Gene:10992 SF3B2 [ReferenceDNASequence:12107512] OMIM:605591 SF3B2
referenceTranscript	[ReferenceRNASequence:12626398] RefSeq:NM_006842.2 SF3B2
schemaClass	ReferenceGeneProduct
secondaryIdentifier	SF3B2_HUMAN A8K485 B4DT19 Q7L4T5 Q7Z627 Q969K1 Q96CM6 Q9BWD2
sequenceLength	895
species	[Species:48887] Homo sapiens
stId	uniprot:Q13435
url	http://purl.uniprot.org/uniprot/Q13435

Referrals

(referenceEntity)

[EntityWithAccessionedSequence:R-HSA-71971] SF3B2 [nucleoplasm]

(interactor)