Reactome | UniProt:Q13363 CTBP1

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UniProt:Q13363 CTBP1 Show undefined attributes

chain	chain:1-440
checksum	F071DD30B385603F
comment	FUNCTION Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation.COFACTOR NAD is required for efficient interaction with E1A. Cofactor binding induces a conformation change.SUBUNIT Homo- or heterodimer. Heterodimer with CTBP2. Interacts with PRDM16; the interaction represses white adipose tissue (WAT)-specific genes expression. Interacts with GLIS2, FOXP2, HDAC4, HDAC5, HDAC9 and ZNF217. Interacts with ELK3 (via its PXDLS motif). Interacts with RBBP8 (via its PXDLS motif); the interaction is disrupted by binding to adenovirus E1A. Interacts with FOXP1, HIPK2, PNN, NRIP1, MECOM, ZFHX1B and WIZ. Interacts with ZNF366 (via PXDLS motif) (PubMed:16393996, PubMed:17085477). Interaction with SATB1 (non-acetylated form); the interaction stabilizes its attachment to DNA and promotes transcription repression. Interacts with BCL6; the interaction is required for BCL6 transcriptional autoinhibition and inhibition of some BCL6 target genes. Interacts with IKZF4 (By similarity). Interacts with MCRIP1 (unphosphorylated form, via the PXDLS motif); competitively inhibiting CTBP-ZEB1 interaction (PubMed:25728771). Interacts with Bassoon/BSN; this interaction targets and anchors CTBP1 to presynapses (By similarity). Interacts with SIMC1 (PubMed:23707407).SUBUNIT (Microbial infection) Interacts with Epstein-Barr virus EBNA3 (PubMed:12372828). Interacts with Epstein-Barr virus EBNA6; this interaction leads to gene repression, but also seems to interfere with the repressive function of CtBP pre-bound to DNA, leading to EBNA6 mediated up-regulation of many cellular genes (PubMed:11462050).SUBUNIT (Microbial infection) Interacts with adenovirus E1A protein (via its C-terminus); the interaction disrupts the interaction of CTBP1 with RBBP8.SUBUNIT (Microbial infection) Interacts with human adenovirus 5 E1A protein; this interaction seems to potentiate viral replication.INTERACTION Expressed in germinal center B-cells.PTM The level of phosphorylation appears to be regulated during the cell cycle. Phosphorylation by HIPK2 on Ser-422 induces proteasomal degradation.PTM ADP-ribosylated; when cells are exposed to brefeldin A.PTM Sumoylation on Lys-428 is promoted by the E3 SUMO-protein ligase CBX4.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
crossReference	[DatabaseIdentifier:11461896] ENSEMBL:ENSG00000159692 [DatabaseIdentifier:12344358] RefSeq:NP_001364122.1 [DatabaseIdentifier:12344356] RefSeq:NP_001364120.1 [DatabaseIdentifier:12344359] RefSeq:NP_001012632.1 [DatabaseIdentifier:12344360] RefSeq:NP_001319.1 [DatabaseIdentifier:12344357] RefSeq:NP_001364121.1 [DatabaseIdentifier:12292885] Pharos - Targets:Q13363 [DatabaseIdentifier:12255156] PRO:Q13363 [DatabaseIdentifier:12227270] PDB:1MX3 [DatabaseIdentifier:12227275] PDB:4U6Q [DatabaseIdentifier:12146257] PDB:8ARI [DatabaseIdentifier:12227272] PDB:7KWM [DatabaseIdentifier:12227278] PDB:6V89 [DatabaseIdentifier:12227277] PDB:6CDF [DatabaseIdentifier:12227271] PDB:6V8A [DatabaseIdentifier:12227274] PDB:6CDR [DatabaseIdentifier:12227276] PDB:4U6S [DatabaseIdentifier:12227273] PDB:4LCE [DatabaseIdentifier:12136776] Orphanet:CTBP1 [DatabaseIdentifier:12132716] OpenTargets:ENSG00000159692 [DatabaseIdentifier:11848030] HPA:ENSG00000159692-CTBP1 [DatabaseIdentifier:11832170] HMDB Protein:HMDBP02216 [DatabaseIdentifier:11810914] GlyGen:Q13363 [DatabaseIdentifier:11795063] GeneCards:CTBP1 [DatabaseIdentifier:11678216] ENSEMBL:ENST00000703163 [DatabaseIdentifier:11678213] ENSEMBL:ENST00000382952 [DatabaseIdentifier:11678215] ENSEMBL:ENST00000290921 [DatabaseIdentifier:11678214] ENSEMBL:ENST00000703138 [DatabaseIdentifier:11555514] ENSEMBL:ENSP00000515211 [DatabaseIdentifier:11555517] ENSEMBL:ENSP00000515195 [DatabaseIdentifier:11555516] ENSEMBL:ENSP00000372411 [DatabaseIdentifier:11555515] ENSEMBL:ENSP00000290921
databaseName	UniProt
dbId	53054
description	recommendedName: C-terminal-binding protein 1 shortName: CtBP1 ecNumber: 1.1.1.-
displayName	UniProt:Q13363 CTBP1
geneName	CTBP1 CTBP
identifier	Q13363
isSequenceChanged	false
keyword	3D-structure ADP-ribosylation Alternative splicing Cytoplasm Differentiation Direct protein sequencing Disease variant Host-virus interaction Intellectual disability Isopeptide bond NAD Nucleus Oxidoreductase Phosphoprotein Proteomics identification Reference proteome Repressor Transcription Transcription regulation Ubl conjugation
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	CTBP1
physicalEntity	[EntityWithAccessionedSequence:R-HSA-212372] CTBP1 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-3108226] polySUMO2,3-K428-CTBP1 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-3108200] monoSUMO1-K428-CTBP1 [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000159692] ENSEMBL:ENSG00000159692 CTBP1 [ReferenceDNASequence:12731948] UCSC:Q13363 CTBP1 [ReferenceDNASequence:12117037] OMIM:602618 CTBP1 [ReferenceDNASequence:12040202] NCBI Gene:1487 CTBP1 [ReferenceDNASequence:11956109] Monarch:1487 CTBP1 [ReferenceDNASequence:11868646] KEGG:hsa:1487 CTBP1 [ReferenceDNASequence:11826760] HGNC:2494 CTBP1 [ReferenceDNASequence:11435418] dbSNP Gene:1487 CTBP1 [ReferenceDNASequence:11423942] CTD Gene:1487 CTBP1 [ReferenceDNASequence:11398578] COSMIC - genes:CTBP1 CTBP1 [ReferenceDNASequence:11326320] BioGPS Gene:1487 CTBP1
referenceTranscript	[ReferenceRNASequence:12526234] RefSeq:NM_001377191.1 CTBP1 [ReferenceRNASequence:12526235] RefSeq:NM_001328.3 CTBP1 [ReferenceRNASequence:12526236] RefSeq:NM_001377193.1 CTBP1 [ReferenceRNASequence:12526232] RefSeq:NM_001377192.1 CTBP1 [ReferenceRNASequence:12526233] RefSeq:NM_001012614.2 CTBP1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	CTBP1_HUMAN Q4W5N3 Q7Z2Q5
sequenceLength	440
species	[Species:48887] Homo sapiens
stId	uniprot:Q13363
url	http://purl.uniprot.org/uniprot/Q13363

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-212372] CTBP1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-3108226] polySUMO2,3-K428-CTBP1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-3108200] monoSUMO1-K428-CTBP1 [nucleoplasm]
(referenceSequence)	[GroupModifiedResidue:3108217] sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 428 [GroupModifiedResidue:3108195] sumoylated lysine (monoSUMO1 [nucleoplasm]) at 428
(interactor)	[UndirectedInteraction:11161799] UniProt:Q13363 <-> UniProt:Q92766 (IntAct) [UndirectedInteraction:11161795] UniProt:Q13363 <-> UniProt:Q8NDX5 (IntAct) [UndirectedInteraction:11161793] UniProt:Q13363 <-> UniProt:Q96AV8 (IntAct) [UndirectedInteraction:11161791] UniProt:Q13363 <-> UniProt:Q6ZRI6 (IntAct) [UndirectedInteraction:11161787] UniProt:Q13363 <-> UniProt:A2APF7 (IntAct) [UndirectedInteraction:11161785] UniProt:Q13363 <-> UniProt:Q9BXL5 (IntAct) [UndirectedInteraction:11161781] UniProt:Q13363 <-> UniProt:Q9NYB0 (IntAct) [UndirectedInteraction:11161779] UniProt:Q13363 <-> UniProt:Q15583 (IntAct) [UndirectedInteraction:11161777] UniProt:Q13363 <-> UniProt:P57682 (IntAct) [UndirectedInteraction:11161775] UniProt:Q13363 <-> UniProt:Q9Y4X4 (IntAct) [UndirectedInteraction:11161771] UniProt:Q13363 <-> UniProt:O43474 (IntAct) [UndirectedInteraction:11161769] UniProt:Q13363 <-> UniProt:P67870 (IntAct) [UndirectedInteraction:11161767] UniProt:Q13363 <-> UniProt:P28749 (IntAct) [UndirectedInteraction:11161765] UniProt:Q13363 <-> UniProt:Q8IZ40 (IntAct) [UndirectedInteraction:11161761] UniProt:Q13363 <-> UniProt:Q13627 (IntAct) [UndirectedInteraction:11161759] UniProt:Q13363 <-> UniProt:Q5JU69 (IntAct) [UndirectedInteraction:11161755] UniProt:Q13363 <-> UniProt:Q09028 (IntAct) [UndirectedInteraction:11161753] UniProt:Q13363 <-> UniProt:P08833 (IntAct) [UndirectedInteraction:11161751] UniProt:Q13363 <-> UniProt:Q96JB3 (IntAct) [UndirectedInteraction:11161747] UniProt:Q13363 <-> UniProt:Q96KQ7 (IntAct) [UndirectedInteraction:11161745] UniProt:Q13363 <-> UniProt:Q9P2K3 (IntAct) [UndirectedInteraction:11161743] UniProt:Q13363 <-> UniProt:Q69140 (IntAct) [UndirectedInteraction:11161739] UniProt:Q13363 <-> UniProt:A7XYQ1 (IntAct) [UndirectedInteraction:11146309] UniProt:P06400 <-> UniProt:Q13363 (IntAct) [UndirectedInteraction:11160011] UniProt:O75362 <-> UniProt:Q13363 (IntAct) [UndirectedInteraction:11161643] UniProt:Q13363 <-> UniProt:P56545 (IntAct) [UndirectedInteraction:11161645] UniProt:Q13363 <-> UniProt:Q96JN0 (IntAct) [UndirectedInteraction:11161647] UniProt:Q13363 <-> UniProt:Q92618 (IntAct) [UndirectedInteraction:11161649] UniProt:Q13363 <-> UniProt:P37275 (IntAct) [UndirectedInteraction:11161653] UniProt:Q13363 <-> UniProt:Q8N3X6 (IntAct) [UndirectedInteraction:11161655] UniProt:Q13363 <-> UniProt:P25054 (IntAct) [UndirectedInteraction:11161657] UniProt:Q13363 <-> UniProt:O60315 (IntAct) [UndirectedInteraction:11161659] UniProt:Q13363 <-> UniProt:Q9UKL0 (IntAct) [UndirectedInteraction:11161661] UniProt:Q13363 <-> UniProt:O60341 (IntAct) [UndirectedInteraction:11161663] UniProt:Q13363 <-> UniProt:Q13547 (IntAct) [UndirectedInteraction:11161665] UniProt:Q13363 <-> UniProt:O95785 (IntAct) [UndirectedInteraction:11161667] UniProt:Q13363 <-> UniProt:Q13363 (IntAct) [UndirectedInteraction:11161667] UniProt:Q13363 <-> UniProt:Q13363 (IntAct) [UndirectedInteraction:11161669] UniProt:Q13363 <-> UniProt:Q99592 (IntAct) [UndirectedInteraction:11161671] UniProt:Q13363 <-> UniProt:Q9H6R7 (IntAct) [UndirectedInteraction:11161675] UniProt:Q13363 <-> UniProt:Q96EK4 (IntAct) [UndirectedInteraction:11161677] UniProt:Q13363 <-> UniProt:Q9UHF7 (IntAct) [UndirectedInteraction:11161679] UniProt:Q13363 <-> UniProt:O00257 (IntAct) [UndirectedInteraction:11161681] UniProt:Q13363 <-> UniProt:Q99708 (IntAct) [UndirectedInteraction:11161683] UniProt:Q13363 <-> UniProt:P48552 (IntAct) [UndirectedInteraction:11161685] UniProt:Q13363 <-> UniProt:Q96PK6 (IntAct) [UndirectedInteraction:11161689] UniProt:Q13363 <-> UniProt:Q96MY1 (IntAct) [UndirectedInteraction:11161691] UniProt:Q13363 <-> UniProt:Q9H9B1 (IntAct) [UndirectedInteraction:11161693] UniProt:Q13363 <-> UniProt:Q92769 (IntAct) [UndirectedInteraction:11161697] UniProt:Q13363 <-> UniProt:Q8N895 (IntAct) [UndirectedInteraction:11161701] UniProt:Q13363 <-> UniProt:Q5H9F3 (IntAct) [UndirectedInteraction:11161703] UniProt:Q13363 <-> UniProt:Q03112 (IntAct) [UndirectedInteraction:11161707] UniProt:Q13363 <-> UniProt:Q13029 (IntAct) [UndirectedInteraction:11161711] UniProt:Q13363 <-> UniProt:O94818 (IntAct) [UndirectedInteraction:11161713] UniProt:Q13363 <-> UniProt:Q9HAZ2 (IntAct) [UndirectedInteraction:11161717] UniProt:Q13363 <-> UniProt:Q9Y5P3 (IntAct) [UndirectedInteraction:11161719] UniProt:Q13363 <-> UniProt:P03255 (IntAct) [UndirectedInteraction:11161721] UniProt:Q13363 <-> UniProt:Q09666 (IntAct) [UndirectedInteraction:11161723] UniProt:Q13363 <-> UniProt:Q14526 (IntAct) [UndirectedInteraction:11161725] UniProt:Q13363 <-> UniProt:Q9Y6V0 (IntAct) [UndirectedInteraction:11161727] UniProt:Q13363 <-> UniProt:Q6W2J9 (IntAct) [UndirectedInteraction:11161729] UniProt:Q13363 <-> UniProt:O15409 (IntAct) [UndirectedInteraction:11161733] UniProt:Q13363 <-> UniProt:Q96JN0-2 (IntAct) [UndirectedInteraction:11161735] UniProt:Q13363 <-> UniProt:Q13422 (IntAct)

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