Reactome | UniProt:Q13347 EIF3I

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UniProt:Q13347 EIF3I Show undefined attributes

chain	chain:1-325
checksum	02797BB72A752A96
comment	FUNCTION Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).SUBUNIT Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.INTERACTION Phosphorylated by TGF-beta type II receptor.MASS SPECTROMETRY Belongs to the eIF-3 subunit I family.
crossReference	[DatabaseIdentifier:12255506] PRO:Q13347 [DatabaseIdentifier:12345564] RefSeq:NP_003748.1 [DatabaseIdentifier:12293225] Pharos - Targets:Q13347 [DatabaseIdentifier:11462376] ENSEMBL:ENSG00000084623 [DatabaseIdentifier:11556333] ENSEMBL:ENSP00000503348 [DatabaseIdentifier:11556332] ENSEMBL:ENSP00000504034 [DatabaseIdentifier:11556336] ENSEMBL:ENSP00000503539 [DatabaseIdentifier:11556335] ENSEMBL:ENSP00000504061 [DatabaseIdentifier:11556334] ENSEMBL:ENSP00000502867 [DatabaseIdentifier:11679031] ENSEMBL:ENST00000677760 [DatabaseIdentifier:11679033] ENSEMBL:ENST00000677202 [DatabaseIdentifier:11679035] ENSEMBL:ENST00000676801 [DatabaseIdentifier:11679032] ENSEMBL:ENST00000677711 [DatabaseIdentifier:11679034] ENSEMBL:ENST00000677701 [DatabaseIdentifier:11795400] GeneCards:EIF3I [DatabaseIdentifier:11811205] GlyGen:Q13347 [DatabaseIdentifier:11848367] HPA:ENSG00000084623-EIF3I [DatabaseIdentifier:12133057] OpenTargets:ENSG00000084623 [DatabaseIdentifier:12148784] PDB:6ZON [DatabaseIdentifier:12148723] PDB:8PJ2 [DatabaseIdentifier:12148738] PDB:8OZ0 [DatabaseIdentifier:12148735] PDB:9BLN [DatabaseIdentifier:12148720] PDB:8PJ4 [DatabaseIdentifier:12148722] PDB:8PJ5 [DatabaseIdentifier:12148727] PDB:8PJ6 [DatabaseIdentifier:12148700] PDB:8PJ1 [DatabaseIdentifier:12148670] PDB:8XXN [DatabaseIdentifier:12148751] PDB:6ZMW [DatabaseIdentifier:12148732] PDB:7A09 [DatabaseIdentifier:12148780] PDB:6ZP4 [DatabaseIdentifier:12148724] PDB:8PJ3 [DatabaseIdentifier:12148742] PDB:6ZVJ [DatabaseIdentifier:12152167] PDB:6YBT
databaseName	UniProt
dbId	72535
description	recommendedName: fullName evidence="1"Eukaryotic translation initiation factor 3 subunit I shortName evidence="1"eIF3i alternativeName: fullName evidence="1"Eukaryotic translation initiation factor 3 subunit 2 alternativeName: TGF-beta receptor-interacting protein 1 shortName: TRIP-1 alternativeName: fullName evidence="1"eIF-3-beta alternativeName: fullName evidence="1"eIF3 p36
displayName	UniProt:Q13347 EIF3I
geneName	EIF3I EIF3S2 TRIP1
identifier	Q13347
isSequenceChanged	false
keyword	3D-structure Acetylation Cytoplasm Direct protein sequencing Initiation factor Isopeptide bond Phosphoprotein Protein biosynthesis Proteomics identification Reference proteome Repeat Ubl conjugation WD repeat
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	EIF3I
otherIdentifier	11747337_x_at 1644_at 16662031 208756_3p_at 208756_PM_at 208756_at 2328801 2328802 2328804 2328806 2328809 2328810 2328811 2328812 2328813 2328814 2328815 2328816 2328817 2328818 2328819 2328820 2328821 2328822 2328823 2328824 2328825 2328826 2328834 3067803 32230_at 58907_at 7899737 8668 A_14_P114436 A_14_P129585 A_14_P200014 A_23_P85560 GE567023 GO:0001732 GO:0002183 GO:0003723 GO:0003743 GO:0005515 GO:0005737 GO:0005829 GO:0005852 GO:0006412 GO:0006413 GO:0016282 GO:0033290 GO:0045202 GO:0065003 GO:0070062 GO:0071541 HMNXSV003016467 HMNXSV003058292 ILMN_1671291 PH_hs_0011309 TC01000424.hg U36764_at g1036804_3p_x_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-72536] EIF3I [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000084623] ENSEMBL:ENSG00000084623 EIF3I [ReferenceDNASequence:12732277] UCSC:Q13347 EIF3I [ReferenceDNASequence:11326787] BioGPS Gene:8668 EIF3I [ReferenceDNASequence:11398641] COSMIC - genes:EIF3I EIF3I [ReferenceDNASequence:11424355] CTD Gene:8668 EIF3I [ReferenceDNASequence:11435484] dbSNP Gene:8668 EIF3I [ReferenceDNASequence:11827102] HGNC:3272 EIF3I [ReferenceDNASequence:11869074] KEGG:hsa:8668 EIF3I [ReferenceDNASequence:11956576] Monarch:8668 EIF3I [ReferenceDNASequence:12040669] NCBI Gene:8668 EIF3I [ReferenceDNASequence:12117352] OMIM:603911 EIF3I
referenceTranscript	[ReferenceRNASequence:12527443] RefSeq:NM_003757.4 EIF3I
schemaClass	ReferenceGeneProduct
secondaryIdentifier	EIF3I_HUMAN
sequenceLength	325
species	[Species:48887] Homo sapiens
stId	uniprot:Q13347
url	http://purl.uniprot.org/uniprot/Q13347

Referrals

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[EntityWithAccessionedSequence:R-HSA-72536] EIF3I [cytosol]

(interactor)