Reactome | UniProt:Q13330 MTA1

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UniProt:Q13330 MTA1 Show undefined attributes

chain	chain:1-715
checksum	2D5330F0489AE62E
comment	FUNCTION Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator (PubMed:16617102, PubMed:17671180, PubMed:17922032, PubMed:21965678, PubMed:24413532). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). In the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA (PubMed:17671180). In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A (PubMed:17922032, PubMed:24413532). Acts as a transcriptional coactivator of BCAS3, and SUMO2, independent of the NuRD complex (PubMed:16617102, PubMed:17671180, PubMed:21965678). Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3 (By similarity). Regulates p53-dependent and -independent DNA repair processes following genotoxic stress (PubMed:19837670). Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair (PubMed:19837670). Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles (By similarity). Positively regulates the CLOCK-BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1 (By similarity). Regulates deacetylation of BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression (By similarity). With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity).FUNCTION Binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses.SUBUNIT Component of the nucleosome remodeling and deacetylase (NuRD) repressor complex, composed of core proteins MTA1, MTA2, MTA3, RBBP4, RBBP7, HDAC1, HDAC2, MBD2, MBD3, and peripherally associated proteins CDK2AP1, CDK2AP2, GATAD2A, GATAD2B, CHD3, CHD4 and CHD5 (PubMed:16428440, PubMed:28977666, PubMed:33283408, PubMed:9885572). The exact stoichiometry of the NuRD complex is unknown, and some subunits such as MBD2 and MBD3, GATAD2A and GATAD2B, and CHD3, CHD4 and CHD5 define mutually exclusive NuRD complexes (PubMed:16428440, PubMed:28977666, PubMed:33283408). Interacts with RBBP4; the interaction is direct (PubMed:24920672). Interacts with BMAL1 (By similarity). Interacts with CLOCK (By similarity). Interacts with COP1 (PubMed:19805145). Interacts with CSNK1G2 in the cytoplasm (PubMed:15077195). Interacts with EP300 (PubMed:16617102). Interacts with HDAC2 (PubMed:17671180, PubMed:19805145, PubMed:21965678, PubMed:24970816). Interacts with IFI16 (PubMed:24413532). Interacts with ITGB3BP/CENPR (PubMed:15254226). Interacts with MBD3L2 (PubMed:15701600). Interacts with MDM2 (PubMed:19837670). Interacts with NACC2 (PubMed:22926524). Interacts with p53/TP53 (PubMed:19837670). Interacts with PIAS1 (PubMed:21965678). Interacts with PIAS3 (PubMed:21965678). Interacts with PIAS4 (PubMed:21965678). Interacts with PWWP2A (PubMed:30327463). Interacts with PWWP2B (By similarity). Interacts with SENP1 (PubMed:21965678). Interacts with SENP2 (PubMed:21965678). Interacts with SIX3; facilitates the binding of SIX3 to the core DNA motif of SIX3 promoter (PubMed:20682799). Interacts with SUMO1 (PubMed:21965678). Interacts with SUMO2 (PubMed:21965678). Interacts with TFCP2L1; which is indispensable for TFCP2L1-mediated self-renewal-promoting effect and endoderm-inhibiting action (By similarity). Interacts with TFAP2C (PubMed:24413532). Interacts with TPR (PubMed:24970816). Interacts with UBE2I/UBC9 (PubMed:21965678).INTERACTION Associated with microtubules (PubMed:24970816). Localization at the nuclear envelope is TPR-dependent (PubMed:24970816).ALTERNATIVE PRODUCTS Widely expressed. High expression in brain, liver, kidney, and cardiac muscle, ovaries, adrenal glands and virgin mammary glands. Higher in tumors than in adjacent normal tissue from the same individual. Up-regulated in a wide variety of cancers including breast, liver, ovarian, and colorectal cancer and its expression levels are closely correlated with tumor aggressiveness and metastasis.DEVELOPMENTAL STAGE Highly expressed in metastatic cells.DOMAIN Isoform Short contains a Leu-Arg-Ile-Leu-Leu motif (ER binding motif).PTM Phosphorylation by CSNK1G2/CK1 triggered by estrogen enhances corepression of estrogen receptor (ER).PTM Acetylation is essential for its transcriptional coactivator activity.PTM Sumoylation positively regulates its transcriptional corepressor activity but does not affect the protein stability. Sumoylated preferentially by SUMO2 or SUMO3 than SUMO1. Sumoylation is enhanced by PIAS1/3/4 and preferentially sumoylated by SUMO2 in the presence of PIAS1/3/4. Desumoylated by SENP1.PTM Ubiquitinated by COP1, which leads to proteasomal degradation.DISEASE Involved in the epigenetic regulation of ESR1 expression in breast cancer in a TFAP2C, IFI16 and HDAC4/5/6-dependent manner.SIMILARITY Belongs to the metastasis-associated protein family.
crossReference	[DatabaseIdentifier:11462346] ENSEMBL:ENSG00000182979 [DatabaseIdentifier:12345468] RefSeq:NP_004680.2 [DatabaseIdentifier:12345469] RefSeq:NP_001190187.1 [DatabaseIdentifier:12345470] RefSeq:NP_001397991.1 [DatabaseIdentifier:12293190] Pharos - Targets:Q13330 [DatabaseIdentifier:12255478] PRO:Q13330 [DatabaseIdentifier:12165204] PDB:4PBY [DatabaseIdentifier:12165207] PDB:6G16 [DatabaseIdentifier:12165205] PDB:5FXY [DatabaseIdentifier:12165179] PDB:6ZRC [DatabaseIdentifier:12151903] PDB:7AO8 [DatabaseIdentifier:12151902] PDB:5ICN [DatabaseIdentifier:12165180] PDB:6ZRD [DatabaseIdentifier:12165210] PDB:4PC0 [DatabaseIdentifier:12151901] PDB:7AOA [DatabaseIdentifier:12151904] PDB:7AO9 [DatabaseIdentifier:12165206] PDB:4PBZ [DatabaseIdentifier:12151898] PDB:4BKX [DatabaseIdentifier:12133021] OpenTargets:ENSG00000182979 [DatabaseIdentifier:11848333] HPA:ENSG00000182979-MTA1 [DatabaseIdentifier:11811176] GlyGen:Q13330 [DatabaseIdentifier:11795364] GeneCards:MTA1 [DatabaseIdentifier:11678975] ENSEMBL:ENST00000331320 [DatabaseIdentifier:11678973] ENSEMBL:ENST00000405646 [DatabaseIdentifier:11678974] ENSEMBL:ENST00000438610 [DatabaseIdentifier:11556275] ENSEMBL:ENSP00000384180 [DatabaseIdentifier:11556276] ENSEMBL:ENSP00000333633 [DatabaseIdentifier:11556274] ENSEMBL:ENSP00000393438
databaseName	UniProt
dbId	59637
description	recommendedName: Metastasis-associated protein MTA1
displayName	UniProt:Q13330 MTA1
geneName	MTA1
identifier	Q13330
isSequenceChanged	false
keyword	3D-structure Acetylation Activator Alternative splicing Biological rhythms Cytoplasm Cytoskeleton DNA-binding Isopeptide bond Metal-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Repressor Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger
modified	[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType	Protein
name	MTA1
otherIdentifier	11727668_a_at 11746358_a_at 11757774_x_at 1642_at 1643_g_at 16789681 202247_PM_s_at 202247_s_at 211783_PM_s_at 211783_s_at 3554746 3554747 3554748 3554749 3554759 3554760 3554767 3554768 3554774 3554775 3554776 3554777 3554778 3554779 3554780 3554781 3554784 3554785 3554787 3554788 3554789 3554790 3554791 3554792 3554793 3554794 3554795 3554796 3554797 3554798 3554799 3554800 3554801 3554802 3554803 3554804 3554805 3554806 3554807 3554808 3554810 3554811 3554812 3554813 3554815 3554816 3554817 38633_at 7977373 9112 A_14_P105611 A_14_P119329 A_14_P123297 A_14_P123899 A_23_P9513 A_24_P241370 A_24_P241373 A_33_P3359306 GE59104 GO:0000122 GO:0000978 GO:0003677 GO:0003682 GO:0003713 GO:0003714 GO:0005515 GO:0005634 GO:0005635 GO:0005654 GO:0005737 GO:0005829 GO:0005856 GO:0005874 GO:0006281 GO:0006302 GO:0006325 GO:0006338 GO:0006355 GO:0007165 GO:0008270 GO:0010212 GO:0016581 GO:0030163 GO:0032922 GO:0042659 GO:0042826 GO:0043153 GO:0043161 GO:0043565 GO:0045475 GO:0045814 GO:0045892 GO:0045893 GO:0046872 GO:0048511 GO:0061629 GO:1902499 GO:2000736 HMNXSV003027770 Hs.101448.0.S1_3p_s_at ILMN_1671911 PH_hs_0005642 TC14000836.hg U35113_at g13544097_3p_s_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-3465550] MTA1 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-3465537] polySUMO2,3-K509-MTA1 [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000182979] ENSEMBL:ENSG00000182979 MTA1 [ReferenceDNASequence:12732246] UCSC:Q13330 MTA1 [ReferenceDNASequence:12117318] OMIM:603526 MTA1 [ReferenceDNASequence:12040637] NCBI Gene:9112 MTA1 [ReferenceDNASequence:11956544] Monarch:9112 MTA1 [ReferenceDNASequence:11869044] KEGG:hsa:9112 MTA1 [ReferenceDNASequence:11827066] HGNC:7410 MTA1 [ReferenceDNASequence:11326755] BioGPS Gene:9112 MTA1 [ReferenceDNASequence:11398632] COSMIC - genes:MTA1 MTA1 [ReferenceDNASequence:11407902] CTD Gene:9112 Q9BRL8 [ReferenceDNASequence:11435475] dbSNP Gene:9112 MTA1
referenceTranscript	[ReferenceRNASequence:12527348] RefSeq:NM_004689.4 MTA1 [ReferenceRNASequence:12527349] RefSeq:NM_001203258.2 MTA1 [ReferenceRNASequence:12527350] RefSeq:NM_001411062.1 MTA1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	MTA1_HUMAN A5PLK4 Q86SW2 Q8NFI8 Q96GI8
sequenceLength	715
species	[Species:48887] Homo sapiens
stId	uniprot:Q13330
url	http://purl.uniprot.org/uniprot/Q13330

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-3465550] MTA1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-3465537] polySUMO2,3-K509-MTA1 [nucleoplasm]
(referenceSequence)	[GroupModifiedResidue:3465540] sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 509
(interactor)	[UndirectedInteraction:11141239] UniProt:Q16576 <-> UniProt:Q13330 (IntAct) [UndirectedInteraction:11170509] UniProt:Q14839 <-> UniProt:Q13330 (IntAct) [UndirectedInteraction:11176705] UniProt:P21673 <-> UniProt:Q13330 (IntAct) [UndirectedInteraction:11179137] UniProt:P0DPK4 <-> UniProt:Q13330 (IntAct) [UndirectedInteraction:11190143] UniProt:Q92769 <-> UniProt:Q13330 (IntAct) [UndirectedInteraction:11192805] UniProt:Q13330 <-> UniProt:Q13547 (IntAct) [UndirectedInteraction:11192807] UniProt:Q13330 <-> UniProt:Q09028 (IntAct) [UndirectedInteraction:11192809] UniProt:Q13330 <-> UniProt:O14519 (IntAct) [UndirectedInteraction:11192811] UniProt:Q13330 <-> UniProt:Q13422 (IntAct) [UndirectedInteraction:11192813] UniProt:Q13330 <-> UniProt:Q6A162 (IntAct) [UndirectedInteraction:11192815] UniProt:Q13330 <-> UniProt:O00629 (IntAct) [UndirectedInteraction:11192817] UniProt:Q13330 <-> UniProt:O60315 (IntAct) [UndirectedInteraction:11192819] UniProt:Q13330 <-> UniProt:O95983 (IntAct) [UndirectedInteraction:11192821] UniProt:Q13330 <-> UniProt:P05412 (IntAct) [UndirectedInteraction:11192823] UniProt:Q13330 <-> UniProt:Q96KQ7 (IntAct) [UndirectedInteraction:11192825] UniProt:Q13330 <-> UniProt:A8MQ03 (IntAct) [UndirectedInteraction:11192827] UniProt:Q13330 <-> UniProt:Q15323 (IntAct) [UndirectedInteraction:11192829] UniProt:Q13330 <-> UniProt:Q9BRK4 (IntAct) [UndirectedInteraction:11192831] UniProt:Q13330 <-> UniProt:O00505 (IntAct) [UndirectedInteraction:11192833] UniProt:Q13330 <-> UniProt:Q99961 (IntAct) [UndirectedInteraction:11192835] UniProt:Q13330 <-> UniProt:Q7Z3S9 (IntAct) [UndirectedInteraction:11192837] UniProt:Q13330 <-> UniProt:P60410 (IntAct) [UndirectedInteraction:11192839] UniProt:Q13330 <-> UniProt:Q58EX7 (IntAct) [UndirectedInteraction:11192841] UniProt:Q13330 <-> UniProt:Q6FGM0 (IntAct) [UndirectedInteraction:11192843] UniProt:Q13330 <-> UniProt:Q16665 (IntAct) [UndirectedInteraction:11192845] UniProt:Q13330 <-> UniProt:Q9NRD5 (IntAct) [UndirectedInteraction:11192847] UniProt:Q13330 <-> UniProt:P43364-2 (IntAct) [UndirectedInteraction:11192849] UniProt:Q13330 <-> UniProt:Q5VWX1 (IntAct) [UndirectedInteraction:11192851] UniProt:Q13330 <-> UniProt:O60341 (IntAct) [UndirectedInteraction:11192853] UniProt:Q13330 <-> UniProt:Q8WXI9 (IntAct) [UndirectedInteraction:11192855] UniProt:Q13330 <-> UniProt:Q86YP4 (IntAct) [UndirectedInteraction:11192857] UniProt:Q13330 <-> UniProt:Q93045 (IntAct) [UndirectedInteraction:11192859] UniProt:Q13330 <-> UniProt:P52294 (IntAct) [UndirectedInteraction:11192861] UniProt:Q13330 <-> UniProt:P19784 (IntAct) [UndirectedInteraction:11192863] UniProt:Q13330 <-> UniProt:Q9UHF7 (IntAct) [UndirectedInteraction:11192865] UniProt:Q13330 <-> UniProt:Q9NSY1 (IntAct) [UndirectedInteraction:11192867] UniProt:Q13330 <-> UniProt:P68431 (IntAct) [UndirectedInteraction:11192869] UniProt:Q13330 <-> UniProt:Q9BRD0 (IntAct) [UndirectedInteraction:11192871] UniProt:Q13330 <-> UniProt:A2A935 (IntAct)

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