Reactome | UniProt:Q13304 GPR17

chain	chain:1-367
checksum	132FBE97BE83C60C
comment	FUNCTION Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.INTERACTION Expressed in brain, kidney, heart and umbilical vein endothelial cells. Highest level in brain.SIMILARITY Belongs to the G-protein coupled receptor 1 family.
crossReference	[DatabaseIdentifier:11462268] ENSEMBL:ENSG00000144230 [DatabaseIdentifier:12818103] ZINC - World Drugs:GPR17_HUMAN [DatabaseIdentifier:12816279] ZINC target:Q13304 [DatabaseIdentifier:12812892] ZINC - Substances:GPR17_HUMAN [DatabaseIdentifier:12808558] ZINC - Predictions - Purchasable:GPR17_HUMAN [DatabaseIdentifier:12807858] ZINC - Metabolites:GPR17_HUMAN [DatabaseIdentifier:12806607] ZINC - Investigational:GPR17_HUMAN [DatabaseIdentifier:12805541] ZINC - FDA approved:GPR17_HUMAN [DatabaseIdentifier:12804377] ZINC - Biogenic:GPR17_HUMAN [DatabaseIdentifier:12345259] RefSeq:NP_001154887.1 [DatabaseIdentifier:12345258] RefSeq:NP_001154888.1 [DatabaseIdentifier:12345256] RefSeq:NP_001154889.1 [DatabaseIdentifier:12345257] RefSeq:NP_005282.1 [DatabaseIdentifier:12293116] Pharos - Targets:Q13304 [DatabaseIdentifier:12255421] PRO:Q13304 [DatabaseIdentifier:12164920] PDB:7Y89 [DatabaseIdentifier:12132946] OpenTargets:ENSG00000144230 [DatabaseIdentifier:11848259] HPA:ENSG00000144230-GPR17 [DatabaseIdentifier:11832389] HMDB Protein:HMDBP10776 [DatabaseIdentifier:11811116] GlyGen:Q13304 [DatabaseIdentifier:11795293] GeneCards:GPR17 [DatabaseIdentifier:11779088] Guide to Pharmacology - Targets:88 [DatabaseIdentifier:11678839] ENSEMBL:ENST00000272644 [DatabaseIdentifier:11678842] ENSEMBL:ENST00000393018 [DatabaseIdentifier:11678841] ENSEMBL:ENST00000486700 [DatabaseIdentifier:11678840] ENSEMBL:ENST00000544369 [DatabaseIdentifier:11556142] ENSEMBL:ENSP00000442982 [DatabaseIdentifier:11556141] ENSEMBL:ENSP00000272644 [DatabaseIdentifier:11556143] ENSEMBL:ENSP00000508383 [DatabaseIdentifier:11556140] ENSEMBL:ENSP00000376741
databaseName	UniProt
dbId	55798
description	recommendedName: Uracil nucleotide/cysteinyl leukotriene receptor shortName: UDP/CysLT receptor alternativeName: G-protein coupled receptor 17 alternativeName: P2Y-like receptor alternativeName: R12
displayName	UniProt:Q13304 GPR17
geneName	GPR17
identifier	Q13304
isSequenceChanged	false
keyword	3D-structure Alternative splicing Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Membrane Proteomics identification Receptor Reference proteome Transducer Transmembrane Transmembrane helix
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	GPR17
physicalEntity	[EntityWithAccessionedSequence:R-HSA-416429] GPR17 [plasma membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000144230] ENSEMBL:ENSG00000144230 GPR17 [ReferenceDNASequence:12732180] UCSC:Q13304 GPR17 [ReferenceDNASequence:12117252] OMIM:603071 GPR17 [ReferenceDNASequence:12040555] NCBI Gene:2840 GPR17 [ReferenceDNASequence:11956462] Monarch:2840 GPR17 [ReferenceDNASequence:11868969] KEGG:hsa:2840 GPR17 [ReferenceDNASequence:11826992] HGNC:4471 GPR17 [ReferenceDNASequence:11435456] dbSNP Gene:2840 GPR17 [ReferenceDNASequence:11424235] CTD Gene:2840 GPR17 [ReferenceDNASequence:11398612] COSMIC - genes:GPR17 GPR17 [ReferenceDNASequence:11326673] BioGPS Gene:2840 GPR17
referenceTranscript	[ReferenceRNASequence:12527134] RefSeq:NM_005291.3 GPR17 [ReferenceRNASequence:12527135] RefSeq:NM_001161415.2 GPR17 [ReferenceRNASequence:12527137] RefSeq:NM_001161417.2 GPR17 [ReferenceRNASequence:12527136] RefSeq:NM_001161416.2 GPR17
schemaClass	ReferenceGeneProduct
secondaryIdentifier	GPR17_HUMAN A8K9L0 B2R9X0 Q8N5S7 Q9UDZ6 Q9UE21
sequenceLength	367
species	[Species:48887] Homo sapiens
stId	uniprot:Q13304
url	http://purl.uniprot.org/uniprot/Q13304

UniProt:Q13304 GPR17 Show undefined attributes

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