UniProt:Q13098 GPS1

chain
  • initiator methionine:1
  • chain:2-491
checksum BF925164ED985638
comment
  • FUNCTION Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.SUBUNIT Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 isoform 1 (PubMed:11337588, PubMed:18850735, PubMed:26456823). In the complex, it probably interacts directly with COPS2, COPS3, COPS4 and COPS5 (PubMed:11114242). Interacts directly with inositol kinase ITPK1 (PubMed:12324474). Interacts with CAPN8 (By similarity). Interacts with USP48 (PubMed:35913642). Interacts with ASB4; this interaction negatively regulates GPS1 (By similarity).INTERACTION Widely expressed.DOMAIN The PCI domain is necessary and sufficient for the interactions with other CSN subunits of the complex. Mediates the interaction with CAPN8 (By similarity).DOMAIN The N-terminal part (1-216), which is not required for deneddylating activity and CSN complex formation, is nevertheless essential for other aspects of CSN complex function, such as repression of c-fos/FOS expression.SIMILARITY Belongs to the CSN1 family.
created [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
crossReference
databaseName UniProt
dbId 416269
description
  • recommendedName: COP9 signalosome complex subunit 1 shortName: SGN1 shortName: Signalosome subunit 1 alternativeName: G protein pathway suppressor 1 shortName: GPS-1 alternativeName: JAB1-containing signalosome subunit 1 alternativeName: Protein MFH
displayName UniProt:Q13098 GPS1
geneName
  • GPS1
  • COPS1
  • CSN1
identifier Q13098
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Cytoplasm
  • Direct protein sequencing
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Signalosome
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • GPS1
otherIdentifier
  • 11715535_a_at
  • 16838988
  • 217782_3p_s_at
  • 217782_PM_s_at
  • 217782_s_at
  • 2873
  • 3738491
  • 3738493
  • 3738494
  • 3738495
  • 3738496
  • 3738497
  • 3738498
  • 3738499
  • 3738500
  • 3738501
  • 3738502
  • 3738503
  • 3738504
  • 3738505
  • 3738506
  • 3738507
  • 3738508
  • 3738509
  • 3738510
  • 3738511
  • 3738512
  • 3738513
  • 3738514
  • 3738515
  • 3738516
  • 3738517
  • 3738518
  • 3738519
  • 3738520
  • 3738521
  • 3738522
  • 3738523
  • 3738524
  • 73190_at
  • 78787_at
  • 8010747
  • A_14_P128722
  • A_23_P158662
  • GE62727
  • GO:0000338
  • GO:0005095
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005737
  • GO:0005829
  • GO:0007254
  • GO:0008180
  • GO:0032991
  • GO:0045116
  • GO:0098772
  • GO:2000434
  • HMNXSV003008519
  • ILMN_1769960
  • ILMN_1795876
  • ILMN_2309228
  • PH_hs_0026722
  • TC17000945.hg
  • U20285_at
  • g13435380_3p_a_at
  • g13435380_3p_at
  • g13435380_3p_x_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • CSN1_HUMAN
  • Q8NA10
  • Q9BWL1
sequenceLength 491
species [Species:48887] Homo sapiens
stId uniprot:Q13098
url http://purl.uniprot.org/uniprot/Q13098
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