UniProt:Q12908 SLC10A2

chain
  • chain:1-348
checksum 9794EAA77C3EC4F9
comment
  • FUNCTION Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine (PubMed:7592981, PubMed:9458785, PubMed:9856990). Transports various bile acids, unconjugated or conjugated, such as cholate and taurocholate (PubMed:7592981, PubMed:9458785, PubMed:9856990). Also responsible for bile acid transport in the renal proximal tubules, a salvage mechanism that helps conserve bile acids (Probable). Works collaboratively with the Na(+)-taurocholate cotransporting polypeptide (NTCP), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation (PubMed:33222321).CATALYTIC ACTIVITY taurocholate(out) + 2 Na(+)(out) = taurocholate(in) + 2 Na(+)(in)CATALYTIC ACTIVITY cholate(out) + 2 Na(+)(out) = cholate(in) + 2 Na(+)(in)CATALYTIC ACTIVITY taurochenodeoxycholate(out) + 2 Na(+)(out) = taurochenodeoxycholate(in) + 2 Na(+)(in)CATALYTIC ACTIVITY tauroursodeoxycholate(out) + 2 Na(+)(out) = tauroursodeoxycholate(in) + 2 Na(+)(in)CATALYTIC ACTIVITY glycocholate(out) + 2 Na(+)(out) = glycocholate(in) + 2 Na(+)(in)CATALYTIC ACTIVITY tauronorcholate(out) + 2 Na(+)(out) = tauronorcholate(in) + 2 Na(+)(in)CATALYTIC ACTIVITY tauroallocholate(out) + 2 Na(+)(out) = tauroallocholate(in) + 2 Na(+)(in)CATALYTIC ACTIVITY taurodeoxycholate(out) + 2 Na(+)(out) = taurodeoxycholate(in) + 2 Na(+)(in)CATALYTIC ACTIVITY tauro-beta-muricholate(out) + 2 Na(+)(out) = tauro-beta-muricholate(in) + 2 Na(+)(in)BIOPHYSICOCHEMICAL PROPERTIES Monomer and homodimer.INTERACTION Mainly expressed in ileum and kidney, lower expression in cecum.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
crossReference
databaseName UniProt
dbId 60528
description
  • recommendedName: Ileal sodium/bile acid cotransporter alternativeName: Apical sodium-dependent bile acid transporter shortName: ASBT alternativeName: Ileal Na(+)/bile acid cotransporter alternativeName: Ileal sodium-dependent bile acid transporter shortName: IBAT shortName: ISBT alternativeName: Na(+)-dependent ileal bile acid transporter alternativeName: Sodium/taurocholate cotransporting polypeptide, ileal alternativeName: Solute carrier family 10 member 2
displayName UniProt:Q12908 SLC10A2
geneName
  • SLC10A2
  • ASBT
  • ISBT
  • NTCP2
identifier Q12908
isSequenceChanged false
keyword
  • Disease variant
  • Glycoprotein
  • Ion transport
  • Lipid transport
  • Membrane
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Sodium
  • Sodium transport
  • Symport
  • Transmembrane
  • Transmembrane helix
  • Transport
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • SLC10A2
otherIdentifier
  • 11729049_at
  • 11729050_at
  • 16780822
  • 207095_PM_at
  • 207095_at
  • 3523993
  • 3523994
  • 3523995
  • 3523997
  • 3523998
  • 3524000
  • 3524001
  • 3524002
  • 3524003
  • 35904_at
  • 6555
  • 7972692
  • A_23_P140009
  • GE79917
  • GO:0005515
  • GO:0005886
  • GO:0005902
  • GO:0006811
  • GO:0006814
  • GO:0006869
  • GO:0008508
  • GO:0009617
  • GO:0015293
  • GO:0015721
  • GO:0016020
  • GO:0016324
  • GO:0055085
  • HMNXSV003052916
  • ILMN_1683670
  • TC13000856.hg
  • U67674_at
  • g4506972_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • NTCP2_HUMAN
  • A1L4F4
  • Q13839
sequenceLength 348
species [Species:48887] Homo sapiens
stId uniprot:Q12908
url http://purl.uniprot.org/uniprot/Q12908
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