Reactome | UniProt:Q12907 LMAN2

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UniProt:Q12907 LMAN2 Show undefined attributes

chain	signal peptide:1-44 chain:45-356
checksum	196193C8E655141C
comment	FUNCTION Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity).COFACTOR Binds 2 calcium ions per subunit.SUBCELLULAR LOCATION Ubiquitous.
crossReference	[DatabaseIdentifier:12320251] RefSeq:NP_006807.1 [DatabaseIdentifier:12285205] Pharos - Targets:Q12907 [DatabaseIdentifier:12244816] PRO:Q12907 [DatabaseIdentifier:12124896] OpenTargets:ENSG00000169223 [DatabaseIdentifier:11840361] HPA:ENSG00000169223-LMAN2 [DatabaseIdentifier:11831315] HMDB Protein:HMDBP07782 [DatabaseIdentifier:11802729] GlyGen:Q12907 [DatabaseIdentifier:11787286] GeneCards:LMAN2 [DatabaseIdentifier:11661593] ENSEMBL:ENST00000303127 [DatabaseIdentifier:11538894] ENSEMBL:ENSP00000303366 [DatabaseIdentifier:11449960] ENSEMBL:ENSG00000169223
databaseName	UniProt
dbId	67238
description	recommendedName: Vesicular integral-membrane protein VIP36 alternativeName: Glycoprotein GP36b alternativeName: Lectin mannose-binding 2 alternativeName: Vesicular integral-membrane protein 36 shortName: VIP36
displayName	UniProt:Q12907 LMAN2
geneName	LMAN2 C5orf8
identifier	Q12907
isSequenceChanged	false
keyword	Calcium Disulfide bond Endoplasmic reticulum Glycoprotein Golgi apparatus Lectin Membrane Metal-binding Protein transport Proteomics identification Reference proteome Signal Transmembrane Transmembrane helix Transport
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	LMAN2
otherIdentifier	10960 11723919_x_at 17003208 200805_PM_at 200805_at 215656_3p_at 215656_PM_at 215656_at 2888693 2888699 2888700 2888701 2888702 2888703 2888704 2888705 2888706 2888707 2888708 2888709 2888710 2888711 2888713 2888716 2888717 2888718 2888719 36955_at 74891_at 74893_g_at 8116020 A_23_P9591 A_24_P9285 GE79770 GO:0000139 GO:0005515 GO:0005537 GO:0005615 GO:0005783 GO:0005789 GO:0005793 GO:0005794 GO:0005886 GO:0006888 GO:0006890 GO:0009986 GO:0015031 GO:0016020 GO:0016192 GO:0030134 GO:0030246 GO:0031072 GO:0031410 GO:0033116 GO:0043226 GO:0046872 GO:0050766 GO:0070062 HMNXSV003028588 Hs.306751.0.S1_3p_x_at ILMN_1776963 PH_hs_0004382 PH_hs_0038805 RNA147690\|p0794_imsncRNA587 TC05002103.hg U10362_at g5803022_3p_at g5803022_3p_x_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-5689829] LMAN2 [endoplasmic reticulum-Golgi intermediate compartment membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5689828] LMAN2 [ER to Golgi transport vesicle membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5689466] LMAN2 [endoplasmic reticulum membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12724880] UCSC:Q12907 LMAN2 [ReferenceDNASequence:12110259] OMIM:609551 LMAN2 [ReferenceDNASequence:12029328] NCBI Gene:10960 LMAN2 [ReferenceDNASequence:11945235] Monarch:10960 LMAN2 [ReferenceDNASequence:11858834] KEGG:hsa:10960 LMAN2 [ReferenceDNASequence:11818925] HGNC:16986 LMAN2 [ReferenceDNASequence:11434514] dbSNP Gene:10960 LMAN2 [ReferenceDNASequence:11412914] CTD Gene:10960 LMAN2 [ReferenceDNASequence:11397773] COSMIC - genes:LMAN2 LMAN2 [ReferenceDNASequence:11315446] BioGPS Gene:10960 LMAN2 [ReferenceDNASequence:ensembl:ENSG00000169223] ENSEMBL:ENSG00000169223 LMAN2
referenceTranscript	[ReferenceRNASequence:12502242] RefSeq:NM_006816.3 LMAN2
schemaClass	ReferenceGeneProduct
secondaryIdentifier	LMAN2_HUMAN Q53HH1
sequenceLength	356
species	[Species:48887] Homo sapiens
stId	uniprot:Q12907
url	http://purl.uniprot.org/uniprot/Q12907

Referrals

(interactor)	[UndirectedInteraction:11148885] UniProt:P13569 <-> UniProt:Q12907 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-5689829] LMAN2 [endoplasmic reticulum-Golgi intermediate compartment membrane] [EntityWithAccessionedSequence:R-HSA-5689828] LMAN2 [ER to Golgi transport vesicle membrane] [EntityWithAccessionedSequence:R-HSA-5689466] LMAN2 [endoplasmic reticulum membrane]