Reactome | UniProt:Q12769 NUP160

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UniProt:Q12769 NUP160 Show undefined attributes

chain	chain:1-1436
checksum	274C063A3CE69F48
comment	FUNCTION Functions as a component of the nuclear pore complex (NPC) (PubMed:11564755, PubMed:11684705). Involved in poly(A)+ RNA transport.SUBUNIT Part of the nuclear pore complex (NPC) (PubMed:11564755, PubMed:11684705). Forms part of the NUP160 subcomplex in the nuclear pore which is composed of NUP160, NUP133, NUP107 and NUP96 (PubMed:11564755, PubMed:11684705). This complex plays a role in RNA export and in tethering NUP98 and NUP153 to the nucleus (PubMed:11564755, PubMed:11684705).INTERACTION The disease may be caused by variants affecting the gene represented in this entry.CAUTION It is uncertain whether Met-1 or Met-35 is the initiator.SEQUENCE CAUTION Probable cloning artifact. Aberrant splice sites.
crossReference	[DatabaseIdentifier:12313365] RefSeq:NP_056046.2 [DatabaseIdentifier:12313364] RefSeq:NP_001305328.1 [DatabaseIdentifier:12282654] Pharos - Targets:Q12769 [DatabaseIdentifier:12240632] PRO:Q12769 [DatabaseIdentifier:12140500] PDB:7R5J [DatabaseIdentifier:12140501] PDB:7R5K [DatabaseIdentifier:12155018] PDB:7PEQ [DatabaseIdentifier:12155016] PDB:5A9Q [DatabaseIdentifier:12137036] Orphanet:NUP160 [DatabaseIdentifier:12122332] OpenTargets:ENSG00000030066 [DatabaseIdentifier:11837834] HPA:ENSG00000030066-NUP160 [DatabaseIdentifier:11800245] GlyGen:Q12769 [DatabaseIdentifier:11784741] GeneCards:NUP160 [DatabaseIdentifier:11656637] ENSEMBL:ENST00000694866 [DatabaseIdentifier:11656638] ENSEMBL:ENST00000526870 [DatabaseIdentifier:11533938] ENSEMBL:ENSP00000511549 [DatabaseIdentifier:11533939] ENSEMBL:ENSP00000431495 [DatabaseIdentifier:11446496] ENSEMBL:ENSG00000030066
databaseName	UniProt
dbId	57693
description	recommendedName: Nuclear pore complex protein Nup160 alternativeName: 160 kDa nucleoporin alternativeName: Nucleoporin Nup160
displayName	UniProt:Q12769 NUP160
geneName	NUP160 KIAA0197 NUP120
identifier	Q12769
isSequenceChanged	false
keyword	3D-structure Alternative splicing Disease variant mRNA transport Nuclear pore complex Nucleus Phosphoprotein Protein transport Proteomics identification Reference proteome Translocation Transport
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	NUP160
otherIdentifier	11736253_a_at 11736254_a_at 11744910_a_at 11750870_a_at 16738205 212709_PM_at 212709_at 214962_PM_s_at 214962_s_at 214963_PM_at 214963_at 23279 3372012 3372013 3372014 3372015 3372016 3372018 3372019 3372020 3372021 3372022 3372024 3372027 3372028 3372029 3372030 3372031 3372032 3372033 3372037 3372038 3372039 3372040 3372042 3372044 3372045 3372046 3372047 3372048 3372049 3372050 3372051 3372052 3372053 3372055 3372057 3372058 3372059 3372060 3372061 3372062 3372065 3372066 3372068 3372072 3372073 3372074 3372075 3372076 3372078 3372079 3372080 3372081 3372082 3372084 3372085 3372086 3372087 3372088 3372089 34253_at 7947991 7948033 7948035 A_23_P43726 A_24_P922606 D83781_at GE79756 GO:0000776 GO:0005515 GO:0005634 GO:0005635 GO:0005643 GO:0005829 GO:0006406 GO:0006913 GO:0015031 GO:0017056 GO:0031080 GO:0043226 GO:0048856 GO:0051028 GO:0072006 HMNXSV003017235 HMNXSV003057120 Hs.22559.0.S1_3p_at Hs.22559.1.S1_3p_at ILMN_1652989 PH_hs_0001971 PH_hs_0031067 TC11001750.hg TC11001751.hg
physicalEntity	[EntityWithAccessionedSequence:R-HSA-157721] NUP160 [nuclear envelope] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-376253] NUP160 [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12722967] UCSC:Q12769 NUP160 [ReferenceDNASequence:12107946] OMIM:607614 NUP160 [ReferenceDNASequence:12026008] NCBI Gene:23279 NUP160 [ReferenceDNASequence:11941915] Monarch:23279 NUP160 [ReferenceDNASequence:11855745] KEGG:hsa:23279 NUP160 [ReferenceDNASequence:11816366] HGNC:18017 NUP160 [ReferenceDNASequence:11434202] dbSNP Gene:23279 NUP160 [ReferenceDNASequence:11408842] CTD Gene:23279 NUP160 [ReferenceDNASequence:11397497] COSMIC - genes:NUP160 NUP160 [ReferenceDNASequence:11312126] BioGPS Gene:23279 NUP160 [ReferenceDNASequence:ensembl:ENSG00000030066] ENSEMBL:ENSG00000030066 NUP160
referenceTranscript	[ReferenceRNASequence:12495420] RefSeq:NM_001318399.1 NUP160 [ReferenceRNASequence:12495421] RefSeq:NM_015231.3 NUP160
schemaClass	ReferenceGeneProduct
secondaryIdentifier	NU160_HUMAN B4DYE8 B4E2J9 Q08AD3 Q7Z5X6 Q96GB3 Q9H660
sequenceLength	1436
species	[Species:48887] Homo sapiens
stId	uniprot:Q12769
url	http://purl.uniprot.org/uniprot/Q12769

Referrals

(interactor)	[UndirectedInteraction:11305507] UniProt:Q5S007 <-> UniProt:Q12769 (IntAct) [UndirectedInteraction:11277071] UniProt:Q8WYP5 <-> UniProt:Q12769 (IntAct) [UndirectedInteraction:11181511] UniProt:P55735 <-> UniProt:Q12769 (IntAct) [UndirectedInteraction:11179679] UniProt:Q9UBP0 <-> UniProt:Q12769 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-157721] NUP160 [nuclear envelope] [EntityWithAccessionedSequence:R-HSA-376253] NUP160 [cytosol]