Reactome | UniProt:Q12136 SAS10

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UniProt:Q12136 SAS10 Show undefined attributes

chain	chain:1-610
checksum	9278BF873834FC7E
comment	FUNCTION Primarily required at the G2/M phase. Essential for viability: involved in nucleolar processing of pre-18S ribosomal RNA as part of the ribosomal small subunit (SSU) processome.SUBUNIT Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.INTERACTION When overexpressed, has a role in the structure of silenced chromatin. Overproduction causes derepression of gene expression at both HML and HMR, as well as at the rDNA locus and at telomeres.SIMILARITY Belongs to the SAS10 family.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference	[DatabaseIdentifier:12311777] RefSeq:NP_010128.1 [DatabaseIdentifier:12239910] PRO:Q12136 [DatabaseIdentifier:12141697] PDB:7D5T [DatabaseIdentifier:12154684] PDB:6ZQG [DatabaseIdentifier:12141679] PDB:5WLC [DatabaseIdentifier:12141677] PDB:9G33 [DatabaseIdentifier:12141690] PDB:7AJT [DatabaseIdentifier:12141687] PDB:7AJU [DatabaseIdentifier:12141694] PDB:6ZQC [DatabaseIdentifier:12141680] PDB:6LQT [DatabaseIdentifier:12151276] PDB:6ZQF [DatabaseIdentifier:12141689] PDB:6ZQA [DatabaseIdentifier:12141692] PDB:6ZQD [DatabaseIdentifier:12141693] PDB:6LQQ [DatabaseIdentifier:12141695] PDB:7D63 [DatabaseIdentifier:12141681] PDB:6LQS [DatabaseIdentifier:12141684] PDB:6LQU [DatabaseIdentifier:12141683] PDB:6LQV [DatabaseIdentifier:12141691] PDB:6LQR [DatabaseIdentifier:12141678] PDB:7D4I [DatabaseIdentifier:12141698] PDB:6KE6 [DatabaseIdentifier:12141685] PDB:6LQP [DatabaseIdentifier:12141696] PDB:7D5S [DatabaseIdentifier:12141673] PDB:7SUK [DatabaseIdentifier:12141682] PDB:6ZQE [DatabaseIdentifier:12154678] PDB:7WTL [DatabaseIdentifier:12141686] PDB:6ZQB [DatabaseIdentifier:11655447] ENSEMBL:YDL153C_mRNA [DatabaseIdentifier:11532748] ENSEMBL:YDL153C [DatabaseIdentifier:11445722] ENSEMBL:YDL153C
databaseName	UniProt
dbId	247477
description	recommendedName: Something about silencing protein 10 alternativeName: U three protein 3 alternativeName: U3 small nucleolar RNA-associated protein 3 alternativeName: U3 snoRNA-associated protein 11
displayName	UniProt:Q12136 SAS10
geneName	SAS10 UTP3 YDL153C D1545
identifier	Q12136
isSequenceChanged	false
keyword	3D-structure Cell cycle Nucleus Phosphoprotein Reference proteome Ribonucleoprotein Ribosome biogenesis rRNA processing
modified	[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType	Protein
name	SAS10
otherIdentifier	851403 GO:0000447 GO:0000462 GO:0000472 GO:0000480 GO:0003674 GO:0005515 GO:0005575 GO:0005634 GO:0005654 GO:0005730 GO:0006364 GO:0007049 GO:0009451 GO:0030490 GO:0031167 GO:0032040 GO:0042254 GO:0042802 GO:1990904
physicalEntity	[EntityWithAccessionedSequence:R-SCE-6790625] SAS10 [nucleoplasm] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-6790637] SAS10 [nucleoplasm] - Saccharomyces cerevisiae
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12722497] UCSC:Q12136 SAS10 [ReferenceDNASequence:12025277] NCBI Gene:851403 SAS10 [ReferenceDNASequence:11941184] Monarch:851403 SAS10 [ReferenceDNASequence:11855056] KEGG:sce:YDL153C SAS10 [ReferenceDNASequence:11311395] BioGPS Gene:851403 SAS10
referenceTranscript	[ReferenceRNASequence:12493861] RefSeq:NM_001180213.1 SAS10
schemaClass	ReferenceGeneProduct
secondaryIdentifier	SAS10_YEAST D6VRJ7 Q05842
sequenceLength	610
species	[Species:68322] Saccharomyces cerevisiae
stId	uniprot:Q12136
url	http://purl.uniprot.org/uniprot/Q12136

Referrals

(interactor)	[UndirectedInteraction:11297023] UniProt:P38333 <-> UniProt:Q12136 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-SCE-6790625] SAS10 [nucleoplasm] [EntityWithAccessionedSequence:R-SCE-6790637] SAS10 [nucleoplasm]

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