UniProt:Q0VGL1 LAMTOR4

chain
  • chain:1-99
  • initiator methionine:1
  • chain:2-99
checksum 0FB3D6613F295DEB
comment
  • FUNCTION As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:22980980, PubMed:28935770, PubMed:29107538, PubMed:29158492, PubMed:30181260). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (PubMed:22980980, PubMed:28935770, PubMed:29107538, PubMed:29158492, PubMed:30181260). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (PubMed:22980980, PubMed:28935770, PubMed:29107538, PubMed:29158492, PubMed:30181260).SUBUNIT Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5 (PubMed:22980980, PubMed:28935770, PubMed:29107538, PubMed:29123114, PubMed:29158492, PubMed:29285400, PubMed:31601708, PubMed:32868926, PubMed:35338845, PubMed:36103527, PubMed:36697823). LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer (PubMed:22980980). The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and RagD/RRAGD; regulated by amino acid availability (PubMed:22980980, PubMed:32868926). The Ragulator complex interacts with SLC38A9; the probable amino acid sensor (PubMed:25561175, PubMed:25567906, PubMed:32868926). Component of the lysosomal folliculin complex (LFC), composed of FLCN, FNIP1 (or FNIP2), RagA/RRAGA or RagB/RRAGB GDP-bound, RagC/RRAGC or RagD/RRAGD GTP-bound, and Ragulator (PubMed:31672913, PubMed:31704029, PubMed:32868926).INTERACTION Phosphorylation at Ser-67 by PKA inhibits Ragulator complex assembly.SIMILARITY Belongs to the LAMTOR4 family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 253431
description
  • recommendedName: fullName evidence="19"Ragulator complex protein LAMTOR4 alternativeName: Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4 component recommendedName: Ragulator complex protein LAMTOR4, N-terminally processed /component
displayName UniProt:Q0VGL1 LAMTOR4
geneName
  • LAMTOR4
  • C7orf59
identifier Q0VGL1
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Lysosome
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • LAMTOR4
otherIdentifier
  • 11757392_a_at
  • 17049170
  • 224890_PM_s_at
  • 224890_s_at
  • 3015316
  • 3015317
  • 3015318
  • 3015319
  • 3015320
  • 3015321
  • 3015322
  • 3015323
  • 3015324
  • 3015325
  • 3015326
  • 3015327
  • 3015328
  • 3015329
  • 389541
  • 8134740
  • 90761_at
  • A_14_P108516
  • A_14_P120962
  • A_33_P3326772
  • GO:0005085
  • GO:0005515
  • GO:0005764
  • GO:0005765
  • GO:0008361
  • GO:0031902
  • GO:0032008
  • GO:0038202
  • GO:0060090
  • GO:0061462
  • GO:0071230
  • GO:0071986
  • GO:1904263
  • GO:1990877
  • HMNXSV003028005
  • Hs.42733.1.S1_3p_a_at
  • Hs.42733.1.S1_3p_x_at
  • ILMN_1779735
  • PH_hs_0035908
  • TC07000615.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • LTOR4_HUMAN
sequenceLength 99
species [Species:48887] Homo sapiens
stId uniprot:Q0VGL1
url http://purl.uniprot.org/uniprot/Q0VGL1
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