Reactome | UniProt:Q09428 ABCC8

chain	chain:1-1581
checksum	09CF2EC97899D1CE
comment	FUNCTION Regulator subunit of pancreatic ATP-sensitive potassium channel (KATP), playing a major role in the regulation of insulin release. In pancreatic cells, it forms KATP channels with KCNJ11; KCNJ11 forms the channel pore while ABCC8 is required for activation and regulation.ACTIVITY REGULATION KATP channels are regulated by cytoplasmic ATP/ADP ratios; ATP inhibits the channel by closing the pore, while ADP activates the channel (PubMed:29286281, PubMed:34815345). Activated by phosphatidylinositol 4,5-biphosphate (PtdIns(4,5)P2) (PubMed:34815345).SUBUNIT Forms an heterooctamer with KCNJ11; four ABCC8/SUR1 molecules interact with one KCNJ11 homotetramer.INTERACTION The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Abundant isoform with prodiabetic properties, predominant in heart.SIMILARITY Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.ONLINE INFORMATION Database for mutations in ABC proteins
created	[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
crossReference	[DatabaseIdentifier:11491627] ENSEMBL:ENSG00000006071 [DatabaseIdentifier:12817856] ZINC - World Drugs:ABCC8_HUMAN [DatabaseIdentifier:12815138] ZINC target:Q09428 [DatabaseIdentifier:12811795] ZINC - Substances:ABCC8_HUMAN [DatabaseIdentifier:12809710] ZINC - Predictions - Purchasable:ABCC8_HUMAN [DatabaseIdentifier:12805328] ZINC - FDA approved:ABCC8_HUMAN [DatabaseIdentifier:12411519] RefSeq:NP_001274103.1 [DatabaseIdentifier:12411520] RefSeq:NP_000343.2 [DatabaseIdentifier:12284808] Pharos - Targets:Q09428 [DatabaseIdentifier:12244288] PRO:Q09428 [DatabaseIdentifier:12173198] PDB:7S5Z [DatabaseIdentifier:12173196] PDB:7S5V [DatabaseIdentifier:12173197] PDB:7S5Y [DatabaseIdentifier:12173200] PDB:7S61 [DatabaseIdentifier:12173193] PDB:6C3O [DatabaseIdentifier:12173199] PDB:7S60 [DatabaseIdentifier:12173195] PDB:7S5X [DatabaseIdentifier:12173194] PDB:6C3P [DatabaseIdentifier:12135761] Orphanet:ABCC8 [DatabaseIdentifier:12124495] OpenTargets:ENSG00000006071 [DatabaseIdentifier:11598439] ENSEMBL:ENSP00000374467 [DatabaseIdentifier:11598437] ENSEMBL:ENSP00000507005 [DatabaseIdentifier:11598440] ENSEMBL:ENSP00000303960 [DatabaseIdentifier:11598438] ENSEMBL:ENSP00000495532 [DatabaseIdentifier:11721136] ENSEMBL:ENST00000302539 [DatabaseIdentifier:11721139] ENSEMBL:ENST00000684593 [DatabaseIdentifier:11721137] ENSEMBL:ENST00000389817 [DatabaseIdentifier:11721138] ENSEMBL:ENST00000644542 [DatabaseIdentifier:11780154] Guide to Pharmacology - Targets:2594 [DatabaseIdentifier:11786886] GeneCards:ABCC8 [DatabaseIdentifier:11802363] GlyGen:Q09428 [DatabaseIdentifier:11830572] HMDB Protein:HMDBP10762 [DatabaseIdentifier:11839966] HPA:ENSG00000006071-ABCC8
databaseName	UniProt
dbId	405344
description	recommendedName: ATP-binding cassette sub-family C member 8 alternativeName: Sulfonylurea receptor 1
displayName	UniProt:Q09428 ABCC8
geneName	ABCC8 HRINS SUR SUR1
identifier	Q09428
isSequenceChanged	false
keyword	3D-structure Alternative splicing ATP-binding Cell membrane Diabetes mellitus Disease variant Disulfide bond Glycoprotein Magnesium Membrane Metal-binding Nucleotide-binding Proteomics identification Receptor Reference proteome Repeat Transmembrane Transmembrane helix Transport
modified	[InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType	Protein
name	ABCC8
otherIdentifier	11723976_at 11753931_a_at 11757771_a_at 16736278 210246_PM_s_at 210246_s_at 3364877 3364879 3364880 3364881 3364882 3364883 3364884 3364885 3364886 3364887 3364888 3364889 3364890 3364891 3364892 3364893 3364894 3364895 3364896 3364897 3364898 3364899 3364900 3364901 3364902 3364903 3364904 3364905 3364906 3364907 3364910 3364913 3364914 3364915 3364916 3364917 3364918 3364919 3364920 3364921 3364922 3364923 3364924 3364925 3364926 3364927 3364929 3364930 3364931 3364933 3364936 3364941 3364946 3364947 3364948 3364949 3364950 3364951 3364952 3364953 3364954 3364955 3364956 3364957 3364958 3364959 3364960 3364961 3364962 3364963 3364964 3364965 3364974 3364975 3364976 3364977 3364978 3364979 3364980 3364981 3364982 3364983 3364984 3364985 3364986 3364987 3364988 3364989 3364992 3364993 3364994 3364998 3364999 3365000 3365001 41792_at 53377_at 53384_g_at 6833 7946860 A_23_P24774 GE57802 GE739435 GE812294 GO:0000166 GO:0001508 GO:0001678 GO:0003013 GO:0005267 GO:0005515 GO:0005524 GO:0005886 GO:0006813 GO:0007565 GO:0007613 GO:0008281 GO:0008282 GO:0008542 GO:0009268 GO:0009410 GO:0010043 GO:0010989 GO:0015272 GO:0016020 GO:0016525 GO:0016787 GO:0016887 GO:0019829 GO:0022414 GO:0022857 GO:0030672 GO:0031004 GO:0031669 GO:0032496 GO:0032760 GO:0032868 GO:0032991 GO:0033198 GO:0035774 GO:0042383 GO:0042734 GO:0043268 GO:0043531 GO:0044325 GO:0046676 GO:0046872 GO:0050768 GO:0050877 GO:0050905 GO:0055085 GO:0060253 GO:0061535 GO:0061855 GO:0071805 GO:0098662 GO:0140359 GO:1900721 GO:1905075 GO:1905604 GO:1990573 HMNXSV003039832 ILMN_1767129 PH_hs_0003567 TC11001457.hg U63455_at g3643189_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-5683140] ABCC8 V187D [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5683122] ABCC8 A1330Gfs*35 [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5683137] ABCC8 F1388del [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5683146] ABCC8 E1507K [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-448770] ABCC8 [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5683253] ABCC8 L213R [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5683251] ABCC8 A1185E [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5683247] ABCC8 P132L [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5683311] ABCC8 L582V [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5683307] ABCC8 R1379C [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5683256] ABCC8 E382K [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5683257] ABCC8 N72S [plasma membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12109894] OMIM:600509 ABCC8 [ReferenceDNASequence:12750253] UCSC:Q09428 ABCC8 [ReferenceDNASequence:ensembl:ENSG00000006071] ENSEMBL:ENSG00000006071 ABCC8 [ReferenceDNASequence:11357060] BioGPS Gene:6833 ABCC8 [ReferenceDNASequence:11401541] COSMIC - genes:ABCC8 ABCC8 [ReferenceDNASequence:11412298] CTD Gene:6833 ABCC8 [ReferenceDNASequence:11438886] dbSNP Gene:6833 ABCC8 [ReferenceDNASequence:11818527] HGNC:59 ABCC8 [ReferenceDNASequence:11896434] KEGG:hsa:6833 ABCC8 [ReferenceDNASequence:11986849] Monarch:6833 ABCC8 [ReferenceDNASequence:12070942] NCBI Gene:6833 ABCC8
referenceTranscript	[ReferenceRNASequence:12593201] RefSeq:NM_000352.6 ABCC8 [ReferenceRNASequence:12593200] RefSeq:NM_001287174.3 ABCC8
schemaClass	ReferenceGeneProduct
secondaryIdentifier	ABCC8_HUMAN A6NMX8 E3UYX6 O75948 Q16583
sequenceLength	1581
species	[Species:48887] Homo sapiens
stId	uniprot:Q09428
url	http://purl.uniprot.org/uniprot/Q09428

UniProt:Q09428 ABCC8 Show undefined attributes

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