Reactome | UniProt:Q08965 BMS1

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UniProt:Q08965 BMS1 Show undefined attributes

chain	chain:1-1183
checksum	9A337F1EE0B0F21D
comment	FUNCTION GTPase required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2 (PubMed:11565748, PubMed:11565749, PubMed:16307926, PubMed:16376378). Controls access of pre-ribosomal RNA intermediates to RCL1 during ribosome biogenesis by binding of RCL1 in a GTP-dependent manner and, via its affinity to U3 snoRNA, delivering it to pre-ribosomes (PubMed:16307926, PubMed:16376378). GTP-binding and/or GTP hydrolysis may induce conformational rearrangements within the BMS1-RCL1 complex allowing the interaction of RCL1 with its RNA substrate (PubMed:25064857). Required for RCL1 import into the nucleus (PubMed:25064857).CATALYTIC ACTIVITY GTP + H2O = GDP + phosphate + H(+)ACTIVITY REGULATION Interactions with RCL1 stimulates its GTPase and U3 snoRNA binding activities (PubMed:16307926, PubMed:16376378). RCL1 activates BMS1 by promoting GDP/GTP exchange (PubMed:16376378).BIOPHYSICOCHEMICAL PROPERTIES Interacts directly with RCL1 and the U3 snoRNA to form a stable subcomplex (PubMed:16307926, PubMed:16376378, PubMed:25064857). Component of the 90S small subunit processome also known as 90S pre-ribosome that consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins (PubMed:27419870, PubMed:27980088, PubMed:28244370, PubMed:28945246, PubMed:32943521, PubMed:32943522, PubMed:33326748, PubMed:35650250, Ref.15).INTERACTION Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. BMS1 subfamily.
crossReference	[DatabaseIdentifier:11519139] ENSEMBL:YPL217C [DatabaseIdentifier:11637313] ENSEMBL:YPL217C [DatabaseIdentifier:11760012] ENSEMBL:YPL217C_mRNA [DatabaseIdentifier:12141679] PDB:5WLC [DatabaseIdentifier:12141690] PDB:7AJT [DatabaseIdentifier:12141694] PDB:6ZQC [DatabaseIdentifier:12141675] PDB:5WYK [DatabaseIdentifier:12141697] PDB:7D5T [DatabaseIdentifier:12141698] PDB:6KE6 [DatabaseIdentifier:12154684] PDB:6ZQG [DatabaseIdentifier:12141673] PDB:7SUK [DatabaseIdentifier:12141689] PDB:6ZQA [DatabaseIdentifier:12141681] PDB:6LQS [DatabaseIdentifier:12154678] PDB:7WTL [DatabaseIdentifier:12141686] PDB:6ZQB [DatabaseIdentifier:12141692] PDB:6ZQD [DatabaseIdentifier:12141685] PDB:6LQP [DatabaseIdentifier:12141677] PDB:9G33 [DatabaseIdentifier:12141678] PDB:7D4I [DatabaseIdentifier:12141684] PDB:6LQU [DatabaseIdentifier:12176382] PDB:4CLQ [DatabaseIdentifier:12141687] PDB:7AJU [DatabaseIdentifier:12141674] PDB:5WYJ [DatabaseIdentifier:12141696] PDB:7D5S [DatabaseIdentifier:12154674] PDB:5TZS [DatabaseIdentifier:12141691] PDB:6LQR [DatabaseIdentifier:12141682] PDB:6ZQE [DatabaseIdentifier:12141683] PDB:6LQV [DatabaseIdentifier:12154685] PDB:5JPQ [DatabaseIdentifier:12151276] PDB:6ZQF [DatabaseIdentifier:12141693] PDB:6LQQ [DatabaseIdentifier:12141680] PDB:6LQT [DatabaseIdentifier:12141695] PDB:7D63 [DatabaseIdentifier:12269754] PRO:Q08965 [DatabaseIdentifier:12466929] RefSeq:NP_015107.1
databaseName	UniProt
dbId	86031
description	recommendedName: fullName evidence="18"Ribosome biogenesis protein BMS1 ecNumber evidence="6 7"3.6.5.-
displayName	UniProt:Q08965 BMS1
geneName	BMS1 YPL217C
identifier	Q08965
isSequenceChanged	false
keyword	3D-structure ATP-binding Cytoplasm GTP-binding Hydrolase Nucleotide-binding Nucleus Phosphoprotein Reference proteome Ribosome biogenesis
modified	[InstanceEdit:9948485] Weiser, Joel, 2025-05-21
moleculeType	Protein
name	BMS1
otherIdentifier	855884 GO:0000166 GO:0000462 GO:0000472 GO:0000479 GO:0000480 GO:0003674 GO:0003723 GO:0003729 GO:0003924 GO:0005515 GO:0005524 GO:0005525 GO:0005575 GO:0005634 GO:0005654 GO:0005730 GO:0005737 GO:0005739 GO:0006364 GO:0008150 GO:0009451 GO:0016787 GO:0016887 GO:0030490 GO:0030686 GO:0031167 GO:0032040 GO:0034511 GO:0042254 GO:0042274 GO:0043167 GO:2000232
physicalEntity	[EntityWithAccessionedSequence:R-SCE-6790720] BMS1 [nucleoplasm] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-6790636] BMS1 [nucleoplasm] - Saccharomyces cerevisiae
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:11383084] BioGPS Gene:855884 BMS1 [ReferenceDNASequence:12767079] UCSC:Q08965 BMS1 [ReferenceDNASequence:11919817] KEGG:sce:YPL217C BMS1 [ReferenceDNASequence:12012873] Monarch:855884 BMS1 [ReferenceDNASequence:12096966] NCBI Gene:855884 BMS1
referenceTranscript	[ReferenceRNASequence:12648391] RefSeq:NM_001184031.1 BMS1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	BMS1_YEAST D6W3F3
sequenceLength	1183
species	[Species:68322] Saccharomyces cerevisiae
stId	uniprot:Q08965
url	http://purl.uniprot.org/uniprot/Q08965

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