Reactome | UniProt:Q08745 RPS10A

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UniProt:Q08745 RPS10A Show undefined attributes

chain	chain:1-105
checksum	E104B39336EE64BB
comment	FUNCTION Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). eS10 plays a role as a positive regulator of the GCN2 kinase activity by stimulating GCN1-mediated GCN2 activation (PubMed:25437641).SUBUNIT Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:22096102, PubMed:9559554). eS10 interacts with GCN1 (via middle region); this interaction is direct and promotes GCN2 kinase activity (PubMed:25437641).SUBCELLULAR LOCATION The N-terminus is not modified.MISCELLANEOUS Present with 54100 molecules/cell in log phase SD medium.MISCELLANEOUS There are 2 genes for eS10 in yeast.SIMILARITY Belongs to the eukaryotic ribosomal protein eS10 family.
crossReference	[DatabaseIdentifier:12142316] PDB:8BN3 [DatabaseIdentifier:12456076] RefSeq:NP_014936.1 [DatabaseIdentifier:12264694] PRO:Q08745 [DatabaseIdentifier:12142414] PDB:4U52 [DatabaseIdentifier:12142408] PDB:4U4N [DatabaseIdentifier:12142400] PDB:5DGV [DatabaseIdentifier:12142417] PDB:4U53 [DatabaseIdentifier:12142422] PDB:4U3U [DatabaseIdentifier:12142407] PDB:6T4Q [DatabaseIdentifier:12142416] PDB:4U4R [DatabaseIdentifier:12142415] PDB:7ZW0 [DatabaseIdentifier:12142425] PDB:7ZUX [DatabaseIdentifier:12142412] PDB:5NDG [DatabaseIdentifier:12142401] PDB:8CDL [DatabaseIdentifier:12142402] PDB:5FCI [DatabaseIdentifier:12142411] PDB:4U51 [DatabaseIdentifier:12142421] PDB:8CEH [DatabaseIdentifier:12142413] PDB:4U4Q [DatabaseIdentifier:12142423] PDB:5ON6 [DatabaseIdentifier:12142404] PDB:5DGF [DatabaseIdentifier:12142418] PDB:5M1J [DatabaseIdentifier:12142424] PDB:5TGM [DatabaseIdentifier:12142409] PDB:4U4O [DatabaseIdentifier:12142403] PDB:5DGE [DatabaseIdentifier:12142410] PDB:4U50 [DatabaseIdentifier:12142405] PDB:8CF5 [DatabaseIdentifier:12142420] PDB:8CMJ [DatabaseIdentifier:12142426] PDB:7ZUW [DatabaseIdentifier:12142361] PDB:8T3B [DatabaseIdentifier:12142366] PDB:8T3E [DatabaseIdentifier:12142360] PDB:8EVT [DatabaseIdentifier:12142374] PDB:6WOO [DatabaseIdentifier:12142329] PDB:6T7I [DatabaseIdentifier:12142369] PDB:8T3C [DatabaseIdentifier:12142390] PDB:7A1G [DatabaseIdentifier:12142341] PDB:7MPJ [DatabaseIdentifier:12142324] PDB:8EUB [DatabaseIdentifier:12142330] PDB:5TBW [DatabaseIdentifier:12142321] PDB:6TNU [DatabaseIdentifier:12142399] PDB:4U3N [DatabaseIdentifier:12142336] PDB:4V8Z [DatabaseIdentifier:12142363] PDB:8EVQ [DatabaseIdentifier:12142343] PDB:7NRD [DatabaseIdentifier:12142362] PDB:6XIR [DatabaseIdentifier:12142310] PDB:4V92 [DatabaseIdentifier:12142359] PDB:8T3A [DatabaseIdentifier:12142354] PDB:6GQ1 [DatabaseIdentifier:12139503] PDB:6ZU9 [DatabaseIdentifier:12142364] PDB:6XIQ [DatabaseIdentifier:12140536] PDB:8YLR [DatabaseIdentifier:12142393] PDB:8K2D [DatabaseIdentifier:12142335] PDB:7N8B [DatabaseIdentifier:12142378] PDB:5OBM [DatabaseIdentifier:12139511] PDB:8CAH [DatabaseIdentifier:12142337] PDB:7ZPQ [DatabaseIdentifier:12142357] PDB:3J77 [DatabaseIdentifier:12142377] PDB:8T2Y [DatabaseIdentifier:12142308] PDB:4U4Z [DatabaseIdentifier:12142344] PDB:7MPI [DatabaseIdentifier:12142394] PDB:5TGA [DatabaseIdentifier:12142351] PDB:8ZHB [DatabaseIdentifier:12142331] PDB:5I4L [DatabaseIdentifier:12142317] PDB:6WDR [DatabaseIdentifier:12142327] PDB:5MEI [DatabaseIdentifier:12142320] PDB:5DAT [DatabaseIdentifier:12142322] PDB:9F9S [DatabaseIdentifier:12142389] PDB:8CKU [DatabaseIdentifier:12142388] PDB:6GQV [DatabaseIdentifier:12142318] PDB:6S47 [DatabaseIdentifier:12142353] PDB:8ZHC [DatabaseIdentifier:12142323] PDB:6T83 [DatabaseIdentifier:12142304] PDB:5LYB [DatabaseIdentifier:12142345] PDB:6SNT [DatabaseIdentifier:12142306] PDB:4U56 [DatabaseIdentifier:12142371] PDB:8ZGR [DatabaseIdentifier:12142370] PDB:8T3D [DatabaseIdentifier:12142372] PDB:8ZH3 [DatabaseIdentifier:12142313] PDB:5DC3 [DatabaseIdentifier:12142392] PDB:6GQB [DatabaseIdentifier:12142367] PDB:8T3F [DatabaseIdentifier:12142381] PDB:8T2Z [DatabaseIdentifier:12142368] PDB:6TB3 [DatabaseIdentifier:12140535] PDB:8Z71 [DatabaseIdentifier:12139514] PDB:6ZCE [DatabaseIdentifier:12142326] PDB:6T7T [DatabaseIdentifier:12142380] PDB:7ZRS [DatabaseIdentifier:12142309] PDB:6SV4 [DatabaseIdentifier:12142355] PDB:6ZVI [DatabaseIdentifier:12142379] PDB:8EVP [DatabaseIdentifier:12142352] PDB:8BQD [DatabaseIdentifier:12142375] PDB:8T2X [DatabaseIdentifier:12142356] PDB:8ZGY [DatabaseIdentifier:12142358] PDB:8EVS [DatabaseIdentifier:12142365] PDB:8EVR [DatabaseIdentifier:12142349] PDB:8EWB [DatabaseIdentifier:12142325] PDB:6HHQ [DatabaseIdentifier:12142339] PDB:8CIV [DatabaseIdentifier:12142315] PDB:4U6F [DatabaseIdentifier:12142333] PDB:8P9A [DatabaseIdentifier:12142348] PDB:3J6Y [DatabaseIdentifier:12142305] PDB:4U4U [DatabaseIdentifier:12142384] PDB:6Z6J [DatabaseIdentifier:11513684] ENSEMBL:YOR293W [DatabaseIdentifier:11629709] ENSEMBL:YOR293W [DatabaseIdentifier:11752408] ENSEMBL:YOR293W_mRNA [DatabaseIdentifier:12142297] PDB:8P85 [DatabaseIdentifier:12142299] PDB:5NDV [DatabaseIdentifier:12142302] PDB:5JUO [DatabaseIdentifier:12142293] PDB:5JUP [DatabaseIdentifier:12142292] PDB:8CG8 [DatabaseIdentifier:12142295] PDB:5JUU [DatabaseIdentifier:12142296] PDB:5JUT [DatabaseIdentifier:12142303] PDB:4U55 [DatabaseIdentifier:12140531] PDB:7B7D [DatabaseIdentifier:12142301] PDB:5NDW [DatabaseIdentifier:12142291] PDB:6RBE [DatabaseIdentifier:12142298] PDB:5MC6 [DatabaseIdentifier:12142294] PDB:5JUS [DatabaseIdentifier:12142300] PDB:6I7O [DatabaseIdentifier:12142398] PDB:8CDR [DatabaseIdentifier:12142314] PDB:8CGN [DatabaseIdentifier:12142340] PDB:8T30 [DatabaseIdentifier:12142334] PDB:4V8Y [DatabaseIdentifier:12142386] PDB:8BQX [DatabaseIdentifier:12142395] PDB:5FCJ [DatabaseIdentifier:12142396] PDB:8PNN [DatabaseIdentifier:12144970] PDB:8Y0U [DatabaseIdentifier:12142383] PDB:8P4V [DatabaseIdentifier:12142385] PDB:8CCS [DatabaseIdentifier:12142328] PDB:8UTI [DatabaseIdentifier:12142311] PDB:8UT0 [DatabaseIdentifier:12142338] PDB:8Z70 [DatabaseIdentifier:12142342] PDB:7NRC [DatabaseIdentifier:12142391] PDB:8XU8 [DatabaseIdentifier:12142332] PDB:8K82 [DatabaseIdentifier:12142350] PDB:8EWC [DatabaseIdentifier:12140532] PDB:8YLD [DatabaseIdentifier:12142312] PDB:6Q8Y [DatabaseIdentifier:12142346] PDB:3J78 [DatabaseIdentifier:12139510] PDB:8CAS [DatabaseIdentifier:12142307] PDB:4U4Y [DatabaseIdentifier:12142319] PDB:4V88 [DatabaseIdentifier:12142347] PDB:3J6X [DatabaseIdentifier:12142382] PDB:6Z6K
databaseName	UniProt
dbId	100672
description	recommendedName: fullName evidence="5"Small ribosomal subunit protein eS10A alternativeName: fullName evidence="6"40S ribosomal protein S10-A
displayName	UniProt:Q08745 RPS10A
geneName	RPS10A YOR293W
identifier	Q08745
isSequenceChanged	false
keyword	3D-structure Cytoplasm Reference proteome Ribonucleoprotein Ribosomal protein
modified	[InstanceEdit:9917590] Weiser, Joel, 2024-08-09
moleculeType	Protein
name	RPS10A
otherIdentifier	854468 GO:0000028 GO:0000054 GO:0002181 GO:0003723 GO:0003735 GO:0005198 GO:0005515 GO:0005575 GO:0005737 GO:0005829 GO:0005840 GO:0006407 GO:0008150 GO:0022627 GO:0031399 GO:0034198 GO:0042594 GO:0045860 GO:0051169 GO:1990904
physicalEntity	[EntityWithAccessionedSequence:R-SCE-9633251] RPS10A [cytosol] - Saccharomyces cerevisiae
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:11378175] BioGPS Gene:854468 RPS10A [ReferenceDNASequence:12764251] UCSC:Q08745 RPS10A [ReferenceDNASequence:11915471] KEGG:sce:YOR293W RPS10A [ReferenceDNASequence:12007964] Monarch:854468 RPS10A [ReferenceDNASequence:12092057] NCBI Gene:854468 RPS10A
referenceTranscript	[ReferenceRNASequence:12637539] RefSeq:NM_001183712.1 RPS10A
schemaClass	ReferenceGeneProduct
secondaryIdentifier	RS10A_YEAST D6W2Z1
sequenceLength	105
species	[Species:68322] Saccharomyces cerevisiae
stId	uniprot:Q08745
url	http://purl.uniprot.org/uniprot/Q08745

Referrals

(referenceEntity)

[EntityWithAccessionedSequence:R-SCE-9633251] RPS10A [cytosol]

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