UniProt:Q08431 MFGE8

chain
  • signal peptide:1-23
  • chain:24-387
  • chain:202-387
  • chain:268-317
checksum 9EA357581933789D
comment
  • FUNCTION Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction.FUNCTION Main constituent of aortic medial amyloid.SUBCELLULAR LOCATION Located in the acrosomal region of zona-pellucida bound sperm.ALTERNATIVE PRODUCTS Mammary epithelial cell surfaces and aortic media. Overexpressed in several carcinomas.DOMAIN The F5/8 type C 2 domain mediates high-affinity binding to phosphatidylserine-containing membranes.PTM Medin has a ragged N-terminus with minor species starting at Pro-264 and Gly-273.MISCELLANEOUS It is unsure whether Met-1 or an upstream Met is the initiator as the upstream Met corresponds to polymorphism rs1879326.
crossReference
databaseName UniProt
dbId 59185
description
  • recommendedName: Lactadherin alternativeName: Breast epithelial antigen BA46 alternativeName: HMFG alternativeName: MFGM alternativeName: Milk fat globule-EGF factor 8 shortName: MFG-E8 alternativeName: SED1 component recommendedName: Lactadherin short form /component component recommendedName: Medin /component
displayName UniProt:Q08431 MFGE8
geneName
  • MFGE8
identifier Q08431
isSequenceChanged false
keyword
  • Alternative splicing
  • Amyloid
  • Angiogenesis
  • Cell adhesion
  • Cytoplasmic vesicle
  • Direct protein sequencing
  • Disulfide bond
  • EGF-like domain
  • Fertilization
  • Glycoprotein
  • Membrane
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Secreted
  • Signal
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • MFGE8
otherIdentifier
  • 11715508_x_at
  • 11748084_a_at
  • 11755066_x_at
  • 1558960_PM_a_at
  • 1558960_a_at
  • 16813038
  • 16813058
  • 210605_PM_s_at
  • 210605_s_at
  • 34403_at
  • 3638205
  • 3638206
  • 3638207
  • 3638208
  • 3638209
  • 3638210
  • 3638211
  • 3638212
  • 3638213
  • 3638214
  • 3638215
  • 3638216
  • 3638217
  • 3638218
  • 3638219
  • 3638220
  • 3638221
  • 3638222
  • 3638223
  • 3638224
  • 3638225
  • 3638226
  • 3638227
  • 3638228
  • 3638229
  • 3638231
  • 3638232
  • 3638233
  • 4240
  • 49911_at
  • 7991234
  • A_23_P48951
  • A_24_P133584
  • GE762774
  • GE79849
  • GO:0001525
  • GO:0001786
  • GO:0002080
  • GO:0005178
  • GO:0005198
  • GO:0005201
  • GO:0005576
  • GO:0005615
  • GO:0005788
  • GO:0007155
  • GO:0007338
  • GO:0009897
  • GO:0012505
  • GO:0016020
  • GO:0016192
  • GO:0022414
  • GO:0030312
  • GO:0031012
  • GO:0031410
  • GO:0043226
  • GO:0043277
  • GO:0070062
  • GO:1903561
  • HMNXSV003021725
  • HMNXSV003023230
  • HMNXSV003031949
  • Hs2.258852.1.S1_3p_s_at
  • PH_hs_0000427
  • PH_hs_0037818
  • S56151_s_at
  • TC15001825.hg
  • TC15001826.hg
  • U58516_at
  • g13177647_3p_x_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • MFGM_HUMAN
  • B2R6M7
  • F5GZN3
  • Q53FU9
  • Q7Z3D2
  • Q9BTL9
sequenceLength 387
species [Species:48887] Homo sapiens
stId uniprot:Q08431
url http://purl.uniprot.org/uniprot/Q08431
Cite Us!