Reactome | UniProt:Q08117 TLE5

chain	chain:1-197
checksum	3851663AA6921A9F
comment	FUNCTION Transcriptional corepressor. Acts as a dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development.SUBUNIT Homooligomer and heterooligomer with other family members. Binds TCF7 (By similarity). Binds the NF-kappa-B subunit RELA. Interacts with PHF12. Interacts (via Q domain) with SIX3. Interacts with SIX6.INTERACTION Found predominantly in muscle, heart and Placenta. In fetal tissues, abundantly expressed in the heart, lung, kidney, brain and liver.DOMAIN Lacks the C-terminal WD repeats.PTM Ubiquitinated by XIAP/BIRC4.SIMILARITY Belongs to the WD repeat Groucho/TLE family.SEQUENCE CAUTION Truncated N-terminus.
crossReference	[DatabaseIdentifier:11512282] ENSEMBL:ENSG00000104964 [DatabaseIdentifier:12453263] RefSeq:NP_945321.1 [DatabaseIdentifier:12453261] RefSeq:NP_001121.2 [DatabaseIdentifier:12453262] RefSeq:NP_945320.1 [DatabaseIdentifier:12284790] Pharos - Targets:Q08117 [DatabaseIdentifier:12263596] PRO:Q08117 [DatabaseIdentifier:12124478] OpenTargets:ENSG00000104964 [DatabaseIdentifier:11839949] HPA:ENSG00000104964-TLE5 [DatabaseIdentifier:11802345] GlyGen:Q08117 [DatabaseIdentifier:11786870] GeneCards:TLE5 [DatabaseIdentifier:11750504] ENSEMBL:ENST00000221561 [DatabaseIdentifier:11750503] ENSEMBL:ENST00000327141 [DatabaseIdentifier:11627804] ENSEMBL:ENSP00000317537 [DatabaseIdentifier:11627805] ENSEMBL:ENSP00000221561
databaseName	UniProt
dbId	55950
description	recommendedName: fullName evidence="11"TLE family member 5 alternativeName: Amino-terminal enhancer of split shortName: Amino enhancer of split alternativeName: Gp130-associated protein GAM alternativeName: Grg-5 alternativeName: Groucho-related protein 5 alternativeName: Protein ESP1 alternativeName: Protein GRG alternativeName: fullName evidence="11"TLE family member 5, transcriptional modulator
displayName	UniProt:Q08117 TLE5
geneName	TLE5 AES GRG GRG5
identifier	Q08117
isSequenceChanged	false
keyword	Alternative splicing Nucleus Phosphoprotein Proteomics identification Reference proteome Repressor Transcription Transcription regulation Ubl conjugation Wnt signaling pathway
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	TLE5
physicalEntity	[EntityWithAccessionedSequence:R-HSA-4648963] AES [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000104964] ENSEMBL:ENSG00000104964 TLE5 [ReferenceDNASequence:12763539] UCSC:Q08117 TLE5 [ReferenceDNASequence:12109882] OMIM:600188 TLE5 [ReferenceDNASequence:12090792] NCBI Gene:166 TLE5 [ReferenceDNASequence:12006699] Monarch:166 TLE5 [ReferenceDNASequence:11914362] KEGG:hsa:166 TLE5 [ReferenceDNASequence:11818510] HGNC:307 TLE5 [ReferenceDNASequence:11440853] dbSNP Gene:166 TLE5 [ReferenceDNASequence:11412271] CTD Gene:166 TLE5 [ReferenceDNASequence:11403256] COSMIC - genes:AES TLE5 [ReferenceDNASequence:11376910] BioGPS Gene:166 TLE5
referenceTranscript	[ReferenceRNASequence:12634767] RefSeq:NM_001130.5 TLE5 [ReferenceRNASequence:12634769] RefSeq:NM_198969.1 TLE5 [ReferenceRNASequence:12634768] RefSeq:NM_198970.1 TLE5
schemaClass	ReferenceGeneProduct
secondaryIdentifier	TLE5_HUMAN B2RBL0 Q12808 Q14CJ1 Q96TG9 Q9UDY9
sequenceLength	197
species	[Species:48887] Homo sapiens
stId	uniprot:Q08117
url	http://purl.uniprot.org/uniprot/Q08117

UniProt:Q08117 TLE5 Show undefined attributes

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