Reactome | UniProt:Q07820 MCL1

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UniProt:Q07820 MCL1 Show undefined attributes

chain	chain:1-350
checksum	D85821AC59275F1F
comment	FUNCTION Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.SUBUNIT Interacts with HIF3A (via C-terminus domain) (By similarity). Interacts with BAD, BOK, BIK and BMF (By similarity). Interacts with PMAIP1 (PubMed:17389404). Interacts with BBC3 (By similarity). Isoform 1 interacts with BAX, BAK1 and TPT1 (PubMed:10837489, PubMed:12149273, PubMed:15077116). Heterodimer of isoform 1 and isoform 2. Homodimers of isoform 1 or isoform 2 are not detected. Isoform 2 does not interact with pro-apoptotic BCL2-related proteins (PubMed:10837489). Interacts with RTL10/BOP (PubMed:23055042). Interacts with BCL2L11; may sequester BCL2L11 to prevent its pro-apoptotic activity (PubMed:10837489, PubMed:17389404, PubMed:20562877, PubMed:27013495). Interacts with GIMAP5 and HSPA8/HSC70; the interaction between HSPA8 and MCL1 is impaired in the absence of GIMAP5 (By similarity).INTERACTION Cytoplasmic, associated with mitochondria.ALTERNATIVE PRODUCTS Expression increases early during phorbol ester-induced differentiation along the monocyte/macrophage pathway in myeloid leukemia cell line ML-1. Rapidly up-regulated by CSF2 in ML-1 cells. Up-regulated by heat shock-induced differentiation. Expression increases early during retinoic acid-induced differentiation.PTM Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment.PTM Rapidly degraded in the absence of phosphorylation on Thr-163 in the PEST region.PTM Phosphorylated on Ser-159, by GSK3, in response to IL3/interleukin-3 withdrawal. Phosphorylation at Ser-159 induces ubiquitination and proteasomal degradation, abrogating the anti-apoptotic activity. Treatment with taxol or okadaic acid induces phosphorylation on additional sites.PTM Ubiquitinated. Ubiquitination is induced by phosphorylation at Ser-159 (PubMed:16543145). Deubiquitinated by USP20; leading to increased stability (PubMed:35063767).SIMILARITY Belongs to the Bcl-2 family.
crossReference	[DatabaseIdentifier:11454527] ENSEMBL:ENSG00000143384 [DatabaseIdentifier:12814935] ZINC target:Q07820 [DatabaseIdentifier:12811605] ZINC - Substances:MCL1_HUMAN [DatabaseIdentifier:12809340] ZINC - Predictions - Purchasable:MCL1_HUMAN [DatabaseIdentifier:12807911] ZINC - Metabolites:MCL1_HUMAN [DatabaseIdentifier:12807203] ZINC - Investigational:MCL1_HUMAN [DatabaseIdentifier:12805066] ZINC - Biogenic:MCL1_HUMAN [DatabaseIdentifier:12328645] RefSeq:NP_001184249.1 [DatabaseIdentifier:12328644] RefSeq:NP_877495.1 [DatabaseIdentifier:12328643] RefSeq:NP_068779.1 [DatabaseIdentifier:12287810] Pharos - Targets:Q07820 [DatabaseIdentifier:12248430] PRO:Q07820 [DatabaseIdentifier:12193107] PDB:8T6F [DatabaseIdentifier:12193092] PDB:8G3U [DatabaseIdentifier:12193084] PDB:6QFC [DatabaseIdentifier:12160457] PDB:6QFM [DatabaseIdentifier:12193094] PDB:8G3X [DatabaseIdentifier:12147808] PDB:5C3F [DatabaseIdentifier:12193086] PDB:6U63 [DatabaseIdentifier:12193093] PDB:6P3P [DatabaseIdentifier:12193103] PDB:5FDO [DatabaseIdentifier:12193089] PDB:6U65 [DatabaseIdentifier:12193110] PDB:6U67 [DatabaseIdentifier:12193090] PDB:8G3W [DatabaseIdentifier:12193083] PDB:5VKC [DatabaseIdentifier:12193097] PDB:5LOF [DatabaseIdentifier:12193100] PDB:5JSB [DatabaseIdentifier:12193096] PDB:8G3S [DatabaseIdentifier:12166231] PDB:2NLA [DatabaseIdentifier:12193101] PDB:6QGD [DatabaseIdentifier:12193108] PDB:8IQM [DatabaseIdentifier:12193106] PDB:6U6F [DatabaseIdentifier:12193105] PDB:2PQK [DatabaseIdentifier:12193099] PDB:4WGI [DatabaseIdentifier:12193091] PDB:8G3T [DatabaseIdentifier:12159325] PDB:3IO9 [DatabaseIdentifier:12193104] PDB:5FDR [DatabaseIdentifier:12193082] PDB:6UDI [DatabaseIdentifier:12193109] PDB:4OQ6 [DatabaseIdentifier:12193112] PDB:6QFQ [DatabaseIdentifier:12193102] PDB:8H7B [DatabaseIdentifier:12193098] PDB:5FC4 [DatabaseIdentifier:12193085] PDB:6U64 [DatabaseIdentifier:12193088] PDB:4OQ5 [DatabaseIdentifier:12193087] PDB:8X62 [DatabaseIdentifier:12159316] PDB:6QFI [DatabaseIdentifier:12159330] PDB:2NL9 [DatabaseIdentifier:12193111] PDB:8VJP [DatabaseIdentifier:12193095] PDB:8G3Y [DatabaseIdentifier:12147810] PDB:2KBW [DatabaseIdentifier:12193041] PDB:5IEZ [DatabaseIdentifier:12159315] PDB:3KJ1 [DatabaseIdentifier:12159337] PDB:6UA3 [DatabaseIdentifier:12193079] PDB:6OQB [DatabaseIdentifier:12193055] PDB:5IF4 [DatabaseIdentifier:12193063] PDB:6BW8 [DatabaseIdentifier:12193036] PDB:9BCG [DatabaseIdentifier:12193053] PDB:7NB7 [DatabaseIdentifier:12193024] PDB:6QYL [DatabaseIdentifier:12193058] PDB:4WMR [DatabaseIdentifier:12193050] PDB:6YBL [DatabaseIdentifier:12193000] PDB:8ZCS [DatabaseIdentifier:12192997] PDB:8SVY [DatabaseIdentifier:12193065] PDB:4WMW [DatabaseIdentifier:12193037] PDB:5W89 [DatabaseIdentifier:12193021] PDB:8Y1Z [DatabaseIdentifier:12193003] PDB:6QXJ [DatabaseIdentifier:12193022] PDB:8Y1Y [DatabaseIdentifier:12193059] PDB:4WMS [DatabaseIdentifier:12193016] PDB:6QYP [DatabaseIdentifier:12193043] PDB:6NE5 [DatabaseIdentifier:12193066] PDB:3KZ0 [DatabaseIdentifier:12193077] PDB:2MHS [DatabaseIdentifier:12193073] PDB:3WIX [DatabaseIdentifier:12193064] PDB:6UD2 [DatabaseIdentifier:12193045] PDB:4ZBF [DatabaseIdentifier:12193035] PDB:4HW2 [DatabaseIdentifier:12193031] PDB:5W8F [DatabaseIdentifier:12193010] PDB:8EKX [DatabaseIdentifier:12193061] PDB:4WMU [DatabaseIdentifier:12193039] PDB:3MK8 [DatabaseIdentifier:12159338] PDB:6VBX [DatabaseIdentifier:12193038] PDB:6QZB [DatabaseIdentifier:12193006] PDB:9CKN [DatabaseIdentifier:12159314] PDB:3KJ0 [DatabaseIdentifier:12193009] PDB:6QZ8 [DatabaseIdentifier:12193070] PDB:6UDV [DatabaseIdentifier:12193051] PDB:4ZBI [DatabaseIdentifier:12193046] PDB:6YBJ [DatabaseIdentifier:12193026] PDB:6MBD [DatabaseIdentifier:12193042] PDB:6O6F [DatabaseIdentifier:12193075] PDB:6UDY [DatabaseIdentifier:12193044] PDB:6YBG [DatabaseIdentifier:12193012] PDB:6O4U [DatabaseIdentifier:12193030] PDB:4HW4 [DatabaseIdentifier:12193074] PDB:3WIY [DatabaseIdentifier:12193054] PDB:8AV9 [DatabaseIdentifier:12193004] PDB:6FS2 [DatabaseIdentifier:12193017] PDB:8EL0 [DatabaseIdentifier:12193001] PDB:6STJ [DatabaseIdentifier:12193081] PDB:6UDT [DatabaseIdentifier:12193040] PDB:6OVC [DatabaseIdentifier:12193013] PDB:6QYO [DatabaseIdentifier:12159336] PDB:3D7V [DatabaseIdentifier:12193080] PDB:6OQD [DatabaseIdentifier:12186888] PDB:5KU9 [DatabaseIdentifier:12193005] PDB:6FS1 [DatabaseIdentifier:12193002] PDB:6FS0 [DatabaseIdentifier:12193032] PDB:6QB4 [DatabaseIdentifier:12193072] PDB:6UDX [DatabaseIdentifier:12193033] PDB:6QB3 [DatabaseIdentifier:12193048] PDB:7NB4 [DatabaseIdentifier:12193071] PDB:6UDU [DatabaseIdentifier:12159309] PDB:5VX2 [DatabaseIdentifier:12193018] PDB:6QZ6 [DatabaseIdentifier:12193076] PDB:6OQN [DatabaseIdentifier:12193015] PDB:6QYN [DatabaseIdentifier:12193023] PDB:6QYK [DatabaseIdentifier:12193014] PDB:8EL1 [DatabaseIdentifier:12192998] PDB:8Y20 [DatabaseIdentifier:12193008] PDB:6ZIE [DatabaseIdentifier:12193011] PDB:6QZ7 [DatabaseIdentifier:12193007] PDB:5C6H [DatabaseIdentifier:12186892] PDB:5MES [DatabaseIdentifier:12186890] PDB:5MEV [DatabaseIdentifier:12159326] PDB:6UAB [DatabaseIdentifier:12193025] PDB:9UGP [DatabaseIdentifier:12192999] PDB:3TWU [DatabaseIdentifier:12193027] PDB:5UUM [DatabaseIdentifier:12193019] PDB:6QZ5 [DatabaseIdentifier:12193078] PDB:6OQC [DatabaseIdentifier:12193029] PDB:4HW3 [DatabaseIdentifier:12193068] PDB:3PK1 [DatabaseIdentifier:12193056] PDB:6B4L [DatabaseIdentifier:12193047] PDB:6O6G [DatabaseIdentifier:12193062] PDB:4WMV [DatabaseIdentifier:12193020] PDB:8QSO [DatabaseIdentifier:12193052] PDB:6YBK [DatabaseIdentifier:12193034] PDB:6QB6 [DatabaseIdentifier:12159343] PDB:3KJ2 [DatabaseIdentifier:12193069] PDB:6BW2 [DatabaseIdentifier:12193067] PDB:4WMX [DatabaseIdentifier:12193057] PDB:7XGE [DatabaseIdentifier:12193049] PDB:6B4U [DatabaseIdentifier:12193028] PDB:6MBE [DatabaseIdentifier:12160454] PDB:4BPJ [DatabaseIdentifier:12160458] PDB:4BPI [DatabaseIdentifier:12193060] PDB:4WMT [DatabaseIdentifier:12127581] OpenTargets:ENSG00000143384 [DatabaseIdentifier:11544750] ENSEMBL:ENSP00000502859 [DatabaseIdentifier:11544748] ENSEMBL:ENSP00000358022 [DatabaseIdentifier:11544749] ENSEMBL:ENSP00000309973 [DatabaseIdentifier:11667447] ENSEMBL:ENST00000307940 [DatabaseIdentifier:11667448] ENSEMBL:ENST00000369026 [DatabaseIdentifier:11667449] ENSEMBL:ENST00000678770 [DatabaseIdentifier:11779802] Guide to Pharmacology - Targets:2847 [DatabaseIdentifier:11789963] GeneCards:MCL1 [DatabaseIdentifier:11842984] HPA:ENSG00000143384-MCL1
databaseName	UniProt
dbId	59063
description	recommendedName: Induced myeloid leukemia cell differentiation protein Mcl-1 alternativeName: Bcl-2-like protein 3 shortName: Bcl2-L-3 alternativeName: Bcl-2-related protein EAT/mcl1 alternativeName: mcl1/EAT
displayName	UniProt:Q07820 MCL1
geneName	MCL1 BCL2L3
identifier	Q07820
isSequenceChanged	false
keyword	3D-structure Alternative splicing Apoptosis Cytoplasm Developmental protein Differentiation Direct protein sequencing Isopeptide bond Membrane Mitochondrion Nucleus Phosphoprotein Proteomics identification Reference proteome Transmembrane Transmembrane helix Ubl conjugation
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	MCL1
otherIdentifier	11715482_a_at 11715483_s_at 11715484_a_at 11715485_a_at 11715486_x_at 11715487_a_at 16692772 16692775 200796_PM_s_at 200796_s_at 200797_PM_s_at 200797_s_at 200798_PM_x_at 200798_x_at 241722_PM_x_at 241722_x_at 2434439 2434441 2434448 2434449 2434450 2434451 2434452 2434453 2434454 2434455 2434456 2434457 2434458 2434459 2434460 2434461 2434462 2434463 2434464 2434465 2434466 2434467 2434468 2434469 2434470 2434471 277_at 33146_at 4170 574406 62246_at 7919743 7919751 A_24_P319635 A_24_P336754 A_24_P336759 A_33_P3275412 A_33_P3336148 GE82631 GE85366 GE86943 GO:0001709 GO:0001836 GO:0005215 GO:0005515 GO:0005634 GO:0005654 GO:0005737 GO:0005739 GO:0005741 GO:0005829 GO:0006915 GO:0006974 GO:0007005 GO:0008053 GO:0008320 GO:0008630 GO:0010507 GO:0015267 GO:0016020 GO:0019725 GO:0030154 GO:0034097 GO:0042981 GO:0043065 GO:0043066 GO:0043525 GO:0046982 GO:0051400 GO:0051434 GO:0055085 GO:0071806 GO:0097136 GO:0097192 GO:1902531 GO:1903378 GO:2000811 GO:2001233 GO:2001240 HMNXSV003005695 HMNXSV003019388 HMNXSV003041006 Hs.160999.1.A1_3p_at Hs.86386.0.S1_3p_a_at Hs.86386.0.S3_3p_a_at ILMN_1705904 ILMN_1756806 ILMN_1803988 L08246_at PH_hs_0004861 TC01003204.hg TC01003205.hg TC01005816.hg g11386164_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-5661490] MCL1 [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:11949294] Monarch:4170 MCL1 [ReferenceDNASequence:12727654] UCSC:Q07820 MCL1 [ReferenceDNASequence:12112443] OMIM:159552 MCL1 [ReferenceDNASequence:12033387] NCBI Gene:4170 MCL1 [ReferenceDNASequence:ensembl:ENSG00000143384] ENSEMBL:ENSG00000143384 MCL1 [ReferenceDNASequence:11319505] BioGPS Gene:4170 MCL1 [ReferenceDNASequence:11398038] COSMIC - genes:MCL1 MCL1 [ReferenceDNASequence:11417017] CTD Gene:4170 MCL1 [ReferenceDNASequence:11434811] dbSNP Gene:4170 MCL1 [ReferenceDNASequence:11821619] HGNC:6943 MCL1 [ReferenceDNASequence:11862423] KEGG:hsa:4170 MCL1
referenceTranscript	[ReferenceRNASequence:12510556] RefSeq:NM_182763.3 MCL1 [ReferenceRNASequence:12510555] RefSeq:NM_001197320.1 MCL1 [ReferenceRNASequence:12510557] RefSeq:NM_021960.5 MCL1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	MCL1_HUMAN B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1
sequenceLength	350
species	[Species:48887] Homo sapiens
stId	uniprot:Q07820
url	http://purl.uniprot.org/uniprot/Q07820

Referrals

(referenceEntity)

[EntityWithAccessionedSequence:R-HSA-5661490] MCL1 [cytosol]

(interactor)

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