Reactome | UniProt:Q07020 RPL18

Schema > ReferenceGeneProduct > Entries

UniProt:Q07020 RPL18 Show undefined attributes

chain	initiator methionine:1 chain:2-188
checksum	C4E416E7A5329B7C
comment	FUNCTION Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547).SUBUNIT Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547).INTERACTION Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity).ALTERNATIVE PRODUCTS The disease may be caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the eukaryotic ribosomal protein eL18 family.
crossReference	[DatabaseIdentifier:11448598] ENSEMBL:ENSG00000063177 [DatabaseIdentifier:12317941] RefSeq:NP_001257419.1 [DatabaseIdentifier:12317940] RefSeq:NP_000970.1 [DatabaseIdentifier:12284037] Pharos - Targets:Q07020 [DatabaseIdentifier:12243225] PRO:Q07020 [DatabaseIdentifier:12145984] PDB:8FKQ [DatabaseIdentifier:12145978] PDB:8FL7 [DatabaseIdentifier:12145976] PDB:8FL6 [DatabaseIdentifier:12139131] PDB:8FL2 [DatabaseIdentifier:12139130] PDB:8FL4 [DatabaseIdentifier:12145985] PDB:8FKR [DatabaseIdentifier:12144887] PDB:8IR1 [DatabaseIdentifier:12145973] PDB:8FKW [DatabaseIdentifier:12145983] PDB:8FKT [DatabaseIdentifier:12148790] PDB:6IP8 [DatabaseIdentifier:12145977] PDB:8FKV [DatabaseIdentifier:12144886] PDB:8IR3 [DatabaseIdentifier:12145974] PDB:8FKX [DatabaseIdentifier:12139132] PDB:8FL3 [DatabaseIdentifier:12148789] PDB:6IP5 [DatabaseIdentifier:12145975] PDB:8FKU [DatabaseIdentifier:12145979] PDB:8FKY [DatabaseIdentifier:12148945] PDB:8FL9 [DatabaseIdentifier:12148793] PDB:9B0F [DatabaseIdentifier:12148946] PDB:8QYX [DatabaseIdentifier:12145981] PDB:8FKP [DatabaseIdentifier:12148947] PDB:7F5S [DatabaseIdentifier:12144885] PDB:8FL0 [DatabaseIdentifier:12145980] PDB:8FKZ [DatabaseIdentifier:12145982] PDB:8FKS [DatabaseIdentifier:12148792] PDB:8UIK [DatabaseIdentifier:12148936] PDB:6W6L [DatabaseIdentifier:12148690] PDB:9B0S [DatabaseIdentifier:12148675] PDB:6OLI [DatabaseIdentifier:12148765] PDB:6Z6L [DatabaseIdentifier:12144889] PDB:8INK [DatabaseIdentifier:12148750] PDB:7XNY [DatabaseIdentifier:12148737] PDB:6ZM7 [DatabaseIdentifier:12148695] PDB:9B0G [DatabaseIdentifier:12148680] PDB:9B0R [DatabaseIdentifier:12148691] PDB:8UIY [DatabaseIdentifier:12148942] PDB:6LSS [DatabaseIdentifier:12148943] PDB:9GY4 [DatabaseIdentifier:12146422] PDB:6ZMO [DatabaseIdentifier:12148718] PDB:9AZC [DatabaseIdentifier:12148683] PDB:9B0O [DatabaseIdentifier:12148676] PDB:8UJB [DatabaseIdentifier:12148696] PDB:9B0H [DatabaseIdentifier:12148757] PDB:8XSY [DatabaseIdentifier:12148923] PDB:8UJC [DatabaseIdentifier:12148733] PDB:6XA1 [DatabaseIdentifier:12145969] PDB:8FLA [DatabaseIdentifier:12148715] PDB:9AZN [DatabaseIdentifier:12148669] PDB:6OLE [DatabaseIdentifier:12148782] PDB:8YOP [DatabaseIdentifier:12148761] PDB:8XSX [DatabaseIdentifier:12148729] PDB:6Y2L [DatabaseIdentifier:12148768] PDB:8QOI [DatabaseIdentifier:12148699] PDB:6Y0G [DatabaseIdentifier:12148939] PDB:8OJ5 [DatabaseIdentifier:12148704] PDB:4UG0 [DatabaseIdentifier:12148930] PDB:7QVP [DatabaseIdentifier:12148668] PDB:9B0W [DatabaseIdentifier:12148938] PDB:8QFD [DatabaseIdentifier:12148741] PDB:9AZS [DatabaseIdentifier:12148931] PDB:8IE3 [DatabaseIdentifier:12148685] PDB:8Y0X [DatabaseIdentifier:12148941] PDB:6LSR [DatabaseIdentifier:12148709] PDB:6OM7 [DatabaseIdentifier:12148933] PDB:9GMO [DatabaseIdentifier:12148924] PDB:8UJD [DatabaseIdentifier:12163790] PDB:6ZVK [DatabaseIdentifier:12145971] PDB:8FLE [DatabaseIdentifier:12148697] PDB:4V6X [DatabaseIdentifier:12145826] PDB:8IDY [DatabaseIdentifier:12145825] PDB:8INF [DatabaseIdentifier:12148744] PDB:8IFE [DatabaseIdentifier:12148777] PDB:5AJ0 [DatabaseIdentifier:12148940] PDB:8OJ8 [DatabaseIdentifier:12148749] PDB:8IFD [DatabaseIdentifier:12148703] PDB:8UKB [DatabaseIdentifier:12144890] PDB:8RL2 [DatabaseIdentifier:12144882] PDB:8IPY [DatabaseIdentifier:12148929] PDB:7BHP [DatabaseIdentifier:12148687] PDB:9B11 [DatabaseIdentifier:12148698] PDB:9B0N [DatabaseIdentifier:12144883] PDB:8IPX [DatabaseIdentifier:12148927] PDB:8FLC [DatabaseIdentifier:12148783] PDB:9G8M [DatabaseIdentifier:12148764] PDB:6Z6M [DatabaseIdentifier:12148928] PDB:8A3D [DatabaseIdentifier:12148686] PDB:9B0P [DatabaseIdentifier:12148672] PDB:8G5Z [DatabaseIdentifier:12148708] PDB:8G6J [DatabaseIdentifier:12148775] PDB:8GLP [DatabaseIdentifier:12148766] PDB:6Z6N [DatabaseIdentifier:12148788] PDB:6IP6 [DatabaseIdentifier:12148689] PDB:8UJ9 [DatabaseIdentifier:12148935] PDB:6LQM [DatabaseIdentifier:12148694] PDB:9B0J [DatabaseIdentifier:12148785] PDB:8YOO [DatabaseIdentifier:12145970] PDB:8FLD [DatabaseIdentifier:12145968] PDB:8INE [DatabaseIdentifier:12144891] PDB:9QIW [DatabaseIdentifier:12148678] PDB:8G61 [DatabaseIdentifier:12150999] PDB:7OW7 [DatabaseIdentifier:12146421] PDB:6ZMI [DatabaseIdentifier:12148934] PDB:8OJ0 [DatabaseIdentifier:12148679] PDB:9B0Q [DatabaseIdentifier:12148712] PDB:6OLZ [DatabaseIdentifier:12148770] PDB:8K2C [DatabaseIdentifier:12148682] PDB:8Y0W [DatabaseIdentifier:12148671] PDB:6OLG [DatabaseIdentifier:12148786] PDB:6Y57 [DatabaseIdentifier:12148937] PDB:8IDT [DatabaseIdentifier:12148716] PDB:6QZP [DatabaseIdentifier:12148925] PDB:8FLF [DatabaseIdentifier:12148684] PDB:8G60 [DatabaseIdentifier:12144892] PDB:8IPD [DatabaseIdentifier:12148932] PDB:8OHD [DatabaseIdentifier:12148944] PDB:6LU8 [DatabaseIdentifier:12145972] PDB:8FLB [DatabaseIdentifier:12148745] PDB:7XNX [DatabaseIdentifier:12163792] PDB:7A01 [DatabaseIdentifier:12148688] PDB:8UIZ [DatabaseIdentifier:12148730] PDB:6ZME [DatabaseIdentifier:12148759] PDB:8XSZ [DatabaseIdentifier:12148926] PDB:6Y6X [DatabaseIdentifier:12148717] PDB:5T2C [DatabaseIdentifier:12148714] PDB:5LKS [DatabaseIdentifier:12148667] PDB:6OLF [DatabaseIdentifier:12148657] PDB:8JDL [DatabaseIdentifier:12148664] PDB:8UJJ [DatabaseIdentifier:12148659] PDB:8JDJ [DatabaseIdentifier:12148662] PDB:6OM0 [DatabaseIdentifier:12148660] PDB:8JDK [DatabaseIdentifier:12148663] PDB:9C3H [DatabaseIdentifier:12148658] PDB:8JDM [DatabaseIdentifier:12148661] PDB:8UJK [DatabaseIdentifier:12148665] PDB:8G5Y [DatabaseIdentifier:12134894] Orphanet:RPL18 [DatabaseIdentifier:12123717] OpenTargets:ENSG00000063177 [DatabaseIdentifier:11839203] HPA:ENSG00000063177-RPL18 [DatabaseIdentifier:11801659] GlyGen:Q07020 [DatabaseIdentifier:11786120] GeneCards:RPL18 [DatabaseIdentifier:11659796] ENSEMBL:ENST00000552588 [DatabaseIdentifier:11659795] ENSEMBL:ENST00000549920 [DatabaseIdentifier:11537096] ENSEMBL:ENSP00000447001 [DatabaseIdentifier:11537097] ENSEMBL:ENSP00000449204
databaseName	UniProt
dbId	72419
description	recommendedName: fullName evidence="9"Large ribosomal subunit protein eL18 alternativeName: 60S ribosomal protein L18
displayName	UniProt:Q07020 RPL18
geneName	RPL18
identifier	Q07020
isSequenceChanged	false
keyword	3D-structure Alternative splicing Cytoplasm Diamond-Blackfan anemia Direct protein sequencing Disease variant Endoplasmic reticulum Isopeptide bond Phosphoprotein Proteomics identification Reference proteome Ribonucleoprotein Ribosomal protein Ubl conjugation
modified	[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType	Protein
name	RPL18
otherIdentifier	11744147_x_at 11763719_a_at 16873987 18671277 18671278 18671279 18671280 18671281 18671282 18671283 18671284 18671285 18671286 18671287 18671288 18671289 18671290 18671291 18671292 200022_PM_at 200022_at 214335_PM_at 214335_at 31546_at 3634715 3867222 3867224 3867225 3867226 3867227 3867228 3867229 3867230 3867231 3867232 3867233 3867234 3867235 3867236 3867237 3867238 3867239 3867240 6141 7892519 7892817 7892868 7893133 7894114 7894858 7895518 7896349 8038086 A_23_P142146 A_24_P356721 GE507012 GO:0002181 GO:0003723 GO:0003735 GO:0005198 GO:0005515 GO:0005634 GO:0005730 GO:0005737 GO:0005783 GO:0005791 GO:0005829 GO:0005840 GO:0005925 GO:0006412 GO:0016020 GO:0022625 GO:0022626 GO:1990904 HMNXSV003025887 Hs.317387.0.S1_3p_x_at Hs.75458.2.S1_3p_at Hs.75458.2.S1_3p_x_at ILMN_1695598 ILMN_2230624 L11566_at PH_hs_0030088 PH_hs_0035920 TC19001687.hg g4506606_3p_at p8399 p8400
physicalEntity	[EntityWithAccessionedSequence:R-HSA-72420] RPL18 [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000063177] ENSEMBL:ENSG00000063177 RPL18 [ReferenceDNASequence:12724111] UCSC:Q07020 RPL18 [ReferenceDNASequence:12109213] OMIM:604179 RPL18 [ReferenceDNASequence:12028076] NCBI Gene:6141 RPL18 [ReferenceDNASequence:11943983] Monarch:6141 RPL18 [ReferenceDNASequence:11857693] KEGG:hsa:6141 RPL18 [ReferenceDNASequence:11817751] HGNC:10310 RPL18 [ReferenceDNASequence:11434399] dbSNP Gene:6141 RPL18 [ReferenceDNASequence:11411003] CTD Gene:6141 RPL18 [ReferenceDNASequence:11397671] COSMIC - genes:RPL18 RPL18 [ReferenceDNASequence:11314194] BioGPS Gene:6141 RPL18
referenceTranscript	[ReferenceRNASequence:12499967] RefSeq:NM_000979.4 RPL18 [ReferenceRNASequence:12499968] RefSeq:NM_001270490.2 RPL18
schemaClass	ReferenceGeneProduct
secondaryIdentifier	RL18_HUMAN F8VWC5 Q8WTZ6
sequenceLength	188
species	[Species:48887] Homo sapiens
stId	uniprot:Q07020
url	http://purl.uniprot.org/uniprot/Q07020

Referrals

(referenceEntity)

[EntityWithAccessionedSequence:R-HSA-72420] RPL18 [cytosol]

(interactor)

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