UniProt:Q05468 RQC1

chain
  • chain:1-723
checksum 8280829BF3A802DB
comment
  • FUNCTION Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:23178123, PubMed:27129255). Within the RQC complex, RQC1 is essential for the recruitment of CDC48 to incompletely synthesized nascent polypeptides that are ubiquitinated by RKR1/LTN1 (PubMed:23479637, PubMed:27129255).SUBUNIT Component of the ribosome quality control complex (RQC), composed of the E3 ubiquitin ligase RKR1/LTN1, RQC1 and RQC2, as well as CDC48 and its ubiquitin-binding cofactors. RQC forms a stable complex with 60S ribosomal subunits (PubMed:23178123, PubMed:23479637).SUBCELLULAR LOCATION Present with 339 molecules/cell in log phase SD medium.SIMILARITY Belongs to the TCF25 family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 255419
description
  • recommendedName: fullName evidence="7"Ribosome quality control complex subunit 1
displayName UniProt:Q05468 RQC1
geneName
  • RQC1
  • YDR333C
identifier Q05468
isSequenceChanged false
keyword
  • 3D-structure
  • Cytoplasm
  • Phosphoprotein
  • Reference proteome
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • RQC1
otherIdentifier
  • 851933
  • GO:0003674
  • GO:0005575
  • GO:0005737
  • GO:0006414
  • GO:0030674
  • GO:0051603
  • GO:0060090
  • GO:0072344
  • GO:1990112
  • GO:1990116
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • RQC1_YEAST
  • D6VSW5
sequenceLength 723
species [Species:68322] Saccharomyces cerevisiae
stId uniprot:Q05468
url http://purl.uniprot.org/uniprot/Q05468
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