UniProt:Q04917 YWHAH

chain
  • initiator methionine:1
  • chain:2-246
checksum D70FBC100C45D6E5
comment
  • FUNCTION Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.SUBUNIT Homodimer (By similarity). Interacts with many nuclear hormone receptors and cofactors including AR, ESR1, ESR2, MC2R, NR3C1, NRIP1, PPARBP and THRA. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with ARHGEF28 and CDK16 (By similarity). Weakly interacts with CDKN1B. Interacts with GAB2. Interacts with KCNK18 in a phosphorylation-dependent manner. Interacts with SAMSN1 (By similarity). Interacts with the 'Ser-241' phosphorylated form of PDPK1. Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB, TBC1D22A and TBC1D22B (PubMed:23572552). Interacts with SLITRK1 (PubMed:19640509). Interacts with MEFV (PubMed:27030597).INTERACTION Expressed mainly in the brain and present in other tissues albeit at lower levels.PTM Phosphorylated on Ser-59 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion.SIMILARITY Belongs to the 14-3-3 family.
crossReference
databaseName UniProt
dbId 48905
description
  • recommendedName: 14-3-3 protein eta alternativeName: Protein AS1
displayName UniProt:Q04917 YWHAH
geneName
  • YWHAH
  • YWHA1
identifier Q04917
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Direct protein sequencing
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • YWHAH
otherIdentifier
  • 11715593_s_at
  • 11756255_x_at
  • 1424_s_at
  • 16929347
  • 201020_PM_at
  • 201020_at
  • 3943208
  • 3943209
  • 3943210
  • 3943211
  • 3943213
  • 3943215
  • 3943218
  • 3943219
  • 3943220
  • 3943221
  • 3943222
  • 7533
  • 8072577
  • A_14_P109968
  • A_23_P103070
  • D78577_s_at
  • GE60439
  • GO:0002028
  • GO:0003779
  • GO:0005159
  • GO:0005515
  • GO:0005737
  • GO:0005739
  • GO:0005829
  • GO:0005886
  • GO:0006355
  • GO:0006629
  • GO:0006713
  • GO:0006886
  • GO:0007165
  • GO:0008092
  • GO:0008104
  • GO:0014704
  • GO:0017080
  • GO:0019899
  • GO:0019904
  • GO:0021762
  • GO:0035259
  • GO:0042802
  • GO:0042921
  • GO:0044325
  • GO:0045202
  • GO:0045664
  • GO:0045893
  • GO:0046982
  • GO:0048167
  • GO:0048856
  • GO:0050774
  • GO:0070062
  • GO:0086010
  • GO:0098772
  • GO:0098793
  • GO:0098978
  • GO:0099171
  • GO:0150048
  • HMNXSV003032556
  • ILMN_1728512
  • PH_hs_0023146
  • TC22000233.hg
  • g4507950_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • 1433F_HUMAN
sequenceLength 246
species [Species:48887] Homo sapiens
stId uniprot:Q04917
url http://purl.uniprot.org/uniprot/Q04917

Referrals

(referenceEntity)
(interactor)
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