UniProt:Q04781 RKR1

chain
  • chain:1-1562
checksum 97AC65E881362305
comment
  • FUNCTION E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:23178123, PubMed:26055716, PubMed:26934223, PubMed:27385828, PubMed:31133701, PubMed:36804914). Mediates ubiquitination of proteins derived from mRNAs lacking stop codons (non-stop proteins) and other translation arrest products induced by poly-lysine sequences and tandem rare codons (PubMed:20835226, PubMed:23825054, PubMed:24261871, PubMed:26934223, PubMed:31133701). Ubiquitination leads to CDC48 recruitment for extraction and degradation of the incomplete translation product (PubMed:26055716, PubMed:27129255). May indirectly play a role in chromatin function and transcription (PubMed:17283062).CATALYTIC ACTIVITY S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.PATHWAY Protein modification; protein ubiquitination.SUBUNIT Component of the ribosome quality control complex (RQC), composed of the E3 ubiquitin ligase RKR1/LTN1, RQC1 and RQC2, as well as CDC48 and its ubiquitin-binding cofactors associated with the 60S ribosomal subunits (PubMed:23178123, PubMed:23479637, PubMed:25349383).SUBCELLULAR LOCATION Formation of detergent-resistant aggregates and inclusions composed of stalled proteins: defects are caused by inability to ubiquitinate and degrade stalled proteins (PubMed:26934223, PubMed:27129255). CAT-tailed protein species tend to aggregate and sequester chaperones and can induce proteotoxic stress (PubMed:26934223, PubMed:27129255).MISCELLANEOUS Present with 222 molecules/cell in log phase SD medium.SIMILARITY Belongs to the LTN1 family.
crossReference
databaseName UniProt
dbId 107510
description
  • recommendedName: fullName evidence="18"E3 ubiquitin-protein ligase listerin ecNumber evidence="4 14"2.3.2.27 alternativeName: fullName evidence="17"RING domain mutant killed by rtf1 deletion protein 1 alternativeName: fullName evidence="19"RING-type E3 ubiquitin transferase listerin
displayName UniProt:Q04781 RKR1
geneName
  • RKR1
  • LTN1
  • YMR247C
  • YM9408.09C
  • YM9920.01C
identifier Q04781
isSequenceChanged false
keyword
  • 3D-structure
  • Cytoplasm
  • Metal-binding
  • Nucleus
  • Reference proteome
  • Repeat
  • Transferase
  • Ubl conjugation pathway
  • Zinc
  • Zinc-finger
modified [InstanceEdit:9917590] Weiser, Joel, 2024-08-09
moleculeType Protein
name
  • RKR1
otherIdentifier
  • 855289
  • GO:0000781
  • GO:0003674
  • GO:0004842
  • GO:0005575
  • GO:0005634
  • GO:0005737
  • GO:0005829
  • GO:0005840
  • GO:0006325
  • GO:0006348
  • GO:0006414
  • GO:0006511
  • GO:0008150
  • GO:0008270
  • GO:0010498
  • GO:0016567
  • GO:0016740
  • GO:0022626
  • GO:0030163
  • GO:0031509
  • GO:0043023
  • GO:0043161
  • GO:0043167
  • GO:0046872
  • GO:0051603
  • GO:0061630
  • GO:0070647
  • GO:0072344
  • GO:1990112
  • GO:1990116
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • LTN1_YEAST
  • D6W074
  • Q04029
sequenceLength 1562
species [Species:68322] Saccharomyces cerevisiae
stId uniprot:Q04781
url http://purl.uniprot.org/uniprot/Q04781
Cite Us!