UniProt:Q04695 KRT17

chain
  • chain:1-432
checksum 35B429243F47EB5C
comment
  • FUNCTION Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.SUBUNIT Heterodimer of a type I and a type II keratin. KRT17 associates with KRT6 isomers (KRT6A or KRT6B). Interacts with TRADD and SFN (By similarity).INTERACTION Expressed in the outer root sheath and medulla region of hair follicle specifically from eyebrow and beard, digital pulp, nail matrix and nail bed epithelium, mucosal stratified squamous epithelia and in basal cells of oral epithelium, palmoplantar epidermis and sweat and mammary glands. Also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland and in exocervix (at protein level).INDUCTION Induced in damaged or stressed epidermis. Induced by the cytokines interferon-gamma (IFN-gamma), tumor necrosis factor alpha (TNF) and transforming growth factor-alpha (TGF-alpha), and by the potent NF-kappa B inhibitor compounds Bay 11-7082 and Bay 11-7085. Down-regulated by the drug Imatinib.PTM Phosphorylation at Ser-44 occurs in a growth- and stress-dependent fashion in skin keratinocytes, it has no effect on filament organization.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE KRT16 and KRT17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris.DISEASE Defects in KRT17 may be the cause of a keratinization disorder with associated thrombocytopenia characterized by generalized harlequin ichthyosis that progress into palmoplantar keratoderma.MISCELLANEOUS There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).SIMILARITY Belongs to the intermediate filament family.SEQUENCE CAUTION Keratin-17 entry
crossReference
databaseName UniProt
dbId 57709
description
  • recommendedName: Keratin, type I cytoskeletal 17 alternativeName: 39.1 alternativeName: Cytokeratin-17 shortName: CK-17 alternativeName: Keratin-17 shortName: K17
displayName UniProt:Q04695 KRT17
geneName
  • KRT17
identifier Q04695
isSequenceChanged false
keyword
  • Coiled coil
  • Cytoplasm
  • Disease variant
  • Ectodermal dysplasia
  • Intermediate filament
  • Isopeptide bond
  • Keratin
  • Palmoplantar keratoderma
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Ubl conjugation
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • KRT17
otherIdentifier
  • 11715280_s_at
  • 11762904_at
  • 11762905_x_at
  • 16844828
  • 17121740
  • 205157_PM_s_at
  • 205157_s_at
  • 212236_PM_x_at
  • 212236_x_at
  • 34301_r_at
  • 3713314
  • 3713315
  • 3713317
  • 3713323
  • 3713325
  • 3747445
  • 3747447
  • 3747451
  • 3747452
  • 3747453
  • 3749293
  • 3749295
  • 3749298
  • 3749300
  • 3749304
  • 3749305
  • 3749306
  • 3751942
  • 3757097
  • 3757214
  • 3757215
  • 3757216
  • 3757217
  • 3757218
  • 3757219
  • 3757220
  • 3757221
  • 3757222
  • 3757223
  • 3757224
  • 3757225
  • 3757226
  • 3757227
  • 3757228
  • 3757229
  • 3757230
  • 3757231
  • 3757232
  • 3757233
  • 3757234
  • 3757235
  • 3872
  • 8013042
  • 8015387
  • A_23_P96158
  • GE79182
  • GO:0001533
  • GO:0002009
  • GO:0005198
  • GO:0005515
  • GO:0005737
  • GO:0005829
  • GO:0005856
  • GO:0005882
  • GO:0005886
  • GO:0007010
  • GO:0030154
  • GO:0030280
  • GO:0030307
  • GO:0030855
  • GO:0031069
  • GO:0031424
  • GO:0045095
  • GO:0045109
  • GO:0045111
  • GO:0045727
  • GO:0051798
  • GO:0071944
  • HMNXSV003050841
  • Hs.2785.1.S1_3p_a_at
  • ILMN_1666845
  • ILMN_1667372
  • PH_hs_0030892
  • TC17002547.hg
  • TC17002908.hg
  • Z19574_rna1_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • K1C17_HUMAN
  • A5Z1M9
  • A5Z1N0
  • A5Z1N1
  • A5Z1N2
  • A6NDV6
  • A6NKQ2
  • Q6IP98
  • Q8N1P6
sequenceLength 432
species [Species:48887] Homo sapiens
stId uniprot:Q04695
url http://purl.uniprot.org/uniprot/Q04695
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