Reactome | UniProt:Q03692 COL10A1

chain	signal peptide:1-18 chain:19-680
checksum	E2F98E53E7882459
comment	FUNCTION Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage.SUBUNIT Homotrimer.INTERACTION Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.DISEASE The disease is caused by variants affecting the gene represented in this entry.
crossReference	[DatabaseIdentifier:11464855] ENSEMBL:ENSG00000123500 [DatabaseIdentifier:12350483] RefSeq:XP_054210196.1 [DatabaseIdentifier:12350484] RefSeq:XP_011533735.1 [DatabaseIdentifier:12350487] RefSeq:NP_001411035.1 [DatabaseIdentifier:12350485] RefSeq:NP_000484.2 [DatabaseIdentifier:12350486] RefSeq:NP_001411036.1 [DatabaseIdentifier:12294870] Pharos - Targets:Q03692 [DatabaseIdentifier:12257456] PRO:Q03692 [DatabaseIdentifier:12235549] PDB:1GR3 [DatabaseIdentifier:12138089] Orphanet:COL10A1 [DatabaseIdentifier:12134709] OpenTargets:ENSG00000123500 [DatabaseIdentifier:11850006] HPA:ENSG00000123500-COL10A1 [DatabaseIdentifier:11797039] GeneCards:COL10A1 [DatabaseIdentifier:11682678] ENSEMBL:ENST00000243222 [DatabaseIdentifier:11682680] ENSEMBL:ENST00000327673 [DatabaseIdentifier:11682679] ENSEMBL:ENST00000651968 [DatabaseIdentifier:11559980] ENSEMBL:ENSP00000327368 [DatabaseIdentifier:11559981] ENSEMBL:ENSP00000498802 [DatabaseIdentifier:11559979] ENSEMBL:ENSP00000243222
databaseName	UniProt
dbId	51144
description	recommendedName: Collagen alpha-1(X) chain
displayName	UniProt:Q03692 COL10A1
geneName	COL10A1
identifier	Q03692
isSequenceChanged	false
keyword	3D-structure Calcium Collagen Disease variant Extracellular matrix Hydroxylation Metal-binding Proteomics identification Reference proteome Repeat Secreted Signal
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	COL10A1
otherIdentifier	11735218_at 11735219_at 1300 17022929 205941_PM_s_at 205941_s_at 217428_PM_s_at 217428_s_at 2970943 2970944 2970945 2970946 2970947 2970948 2970949 2970950 2970951 2970952 2970963 38566_at 8129082 A_23_P214144 GO:0001501 GO:0005198 GO:0005515 GO:0005576 GO:0005581 GO:0005599 GO:0005788 GO:0030020 GO:0030312 GO:0031012 GO:0046872 GO:0048856 HMNXSV003010399 Hs.179729.0.S1_3p_a_at Hs.179729.1.S1_3p_a_at ILMN_1672776 PH_hs_0010643 TC06002044.hg X60382_rna1_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-2173263] 3x4Hyp-3Hyp-GlcGalHyl-COL10A1 [endoplasmic reticulum lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2173066] GalHyl-COL10A1 [endoplasmic reticulum lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2173242] 3x4Hyp-3Hyp-GalHyl-COL10A1 [endoplasmic reticulum lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2192753] 3x4Hyp-COL10A1 [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2192771] 3x4Hyp-3Hyp-GlcGalHyl-COL10A1 [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2192754] 3x4Hyp-GalHyl-COL10A1 [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2192773] 3x4Hyp-GlcGalHyl-COL10A1 [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2192788] 3x4Hyp-3Hyp-GalHyl-COL10A1 [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2192772] 5Hyl-COL10A1 [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2192775] GalHyl-COL10A1 [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2192790] 3x4Hyp-3Hyp-COL10A1 [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2192778] 3x4Hyp-3Hyp-5Hyl-COL10A1 [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2192765] GlcGalHyl-COL10A1 [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1430776] COL10A1 [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2192766] 3x4Hyp-5Hyl-COL10A1 [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2470533] 3x4Hyp-3Hyp-GalHyl-COL10A1(?-680) [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2470535] 3x4Hyp-GlcGalHyl-COL10A1(19-?) [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2470534] 3x4Hyp-COL10A1(?-680) [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2470529] 3x4Hyp-3Hyp-GalHyl-COL10A1(19-?) [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2470530] 5Hyl-COL10A1(?-680) [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2470511] 3x4Hyp-5Hyl-COL10A1(?-680) [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2470537] 3x4Hyp-3Hyp-COL10A1(?-680) [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2470536] 3x4Hyp-GalHyl-COL10A1(?-680) [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2470539] COL10A1(?-680) [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2470538] GalHyl-COL10A1(19-?) [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2470516] GalHyl-COL10A1(?-680) [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2470518] COL10A1(19-?) [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2470512] 3x4Hyp-COL10A1(19-?) [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2470515] 3x4Hyp-GalHyl-COL10A1(19-?) [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2470525] 3x4Hyp-3Hyp-GlcGalHyl-COL10A1(19-?) [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2470524] 3x4Hyp-GlcGalHyl-COL10A1(?-680) [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2470527] GlcGalHyl-COL10A1(?-680) [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2470526] 3x4Hyp-3Hyp-GlcGalHyl-COL10A1(?-680) [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2470521] 3x4Hyp-3Hyp-COL10A1(19-?) [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2470522] 3x4Hyp-5Hyl-COL10A1(19-?) [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2173007] 5Hyl-COL10A1 [endoplasmic reticulum lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2173232] 3x4Hyp-3Hyp-5Hyl-COL10A1 [endoplasmic reticulum lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2173152] 3x4Hyp-5Hyl-COL10A1 [endoplasmic reticulum lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2172964] 3x4Hyp-3Hyp-COL10A1 [endoplasmic reticulum lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2172959] 3x4Hyp-COL10A1 [endoplasmic reticulum lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2172268] COL10A1 [endoplasmic reticulum lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2173168] 3x4Hyp-GalHyl-COL10A1 [endoplasmic reticulum lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2173104] GlcGalHyl-COL10A1 [endoplasmic reticulum lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2173191] 3x4Hyp-GlcGalHyl-COL10A1 [endoplasmic reticulum lumen] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000123500] ENSEMBL:ENSG00000123500 COL10A1 [ReferenceDNASequence:12680601] UCSC:Q03692 COL10A1 [ReferenceDNASequence:12118852] OMIM:120110 COL10A1 [ReferenceDNASequence:12042984] NCBI Gene:1300 COL10A1 [ReferenceDNASequence:11958891] Monarch:1300 COL10A1 [ReferenceDNASequence:11871204] KEGG:hsa:1300 COL10A1 [ReferenceDNASequence:11828755] HGNC:2185 COL10A1 [ReferenceDNASequence:11428044] dbSNP Gene:1300 COL10A1 [ReferenceDNASequence:11426449] CTD Gene:1300 COL10A1 [ReferenceDNASequence:11392279] COSMIC - genes:COL10A1 COL10A1 [ReferenceDNASequence:11329102] BioGPS Gene:1300 COL10A1
referenceTranscript	[ReferenceRNASequence:12532343] RefSeq:XM_054354221.1 COL10A1 [ReferenceRNASequence:12532342] RefSeq:NM_000493.3 COL10A1 [ReferenceRNASequence:12532339] RefSeq:NM_001424107.1 COL10A1 [ReferenceRNASequence:12532340] RefSeq:XM_011535433.4 COL10A1 [ReferenceRNASequence:12532341] RefSeq:NM_001424106.1 COL10A1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	COAA1_HUMAN A1L4P2
sequenceLength	680
species	[Species:48887] Homo sapiens
stId	uniprot:Q03692
url	http://purl.uniprot.org/uniprot/Q03692

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-2173263] 3x4Hyp-3Hyp-GlcGalHyl-COL10A1 [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-HSA-2173066] GalHyl-COL10A1 [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-HSA-2173242] 3x4Hyp-3Hyp-GalHyl-COL10A1 [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-HSA-2192753] 3x4Hyp-COL10A1 [extracellular region] [EntityWithAccessionedSequence:R-HSA-2192771] 3x4Hyp-3Hyp-GlcGalHyl-COL10A1 [extracellular region] [EntityWithAccessionedSequence:R-HSA-2192754] 3x4Hyp-GalHyl-COL10A1 [extracellular region] [EntityWithAccessionedSequence:R-HSA-2192773] 3x4Hyp-GlcGalHyl-COL10A1 [extracellular region] [EntityWithAccessionedSequence:R-HSA-2192788] 3x4Hyp-3Hyp-GalHyl-COL10A1 [extracellular region] [EntityWithAccessionedSequence:R-HSA-2192772] 5Hyl-COL10A1 [extracellular region] [EntityWithAccessionedSequence:R-HSA-2192775] GalHyl-COL10A1 [extracellular region] [EntityWithAccessionedSequence:R-HSA-2192790] 3x4Hyp-3Hyp-COL10A1 [extracellular region] [EntityWithAccessionedSequence:R-HSA-2192778] 3x4Hyp-3Hyp-5Hyl-COL10A1 [extracellular region] [EntityWithAccessionedSequence:R-HSA-2192765] GlcGalHyl-COL10A1 [extracellular region] [EntityWithAccessionedSequence:R-HSA-1430776] COL10A1 [extracellular region] [EntityWithAccessionedSequence:R-HSA-2192766] 3x4Hyp-5Hyl-COL10A1 [extracellular region] [EntityWithAccessionedSequence:R-HSA-2470533] 3x4Hyp-3Hyp-GalHyl-COL10A1(?-680) [extracellular region] [EntityWithAccessionedSequence:R-HSA-2470535] 3x4Hyp-GlcGalHyl-COL10A1(19-?) [extracellular region] [EntityWithAccessionedSequence:R-HSA-2470534] 3x4Hyp-COL10A1(?-680) [extracellular region] [EntityWithAccessionedSequence:R-HSA-2470529] 3x4Hyp-3Hyp-GalHyl-COL10A1(19-?) [extracellular region] [EntityWithAccessionedSequence:R-HSA-2470530] 5Hyl-COL10A1(?-680) [extracellular region] [EntityWithAccessionedSequence:R-HSA-2470511] 3x4Hyp-5Hyl-COL10A1(?-680) [extracellular region] [EntityWithAccessionedSequence:R-HSA-2470537] 3x4Hyp-3Hyp-COL10A1(?-680) [extracellular region] [EntityWithAccessionedSequence:R-HSA-2470536] 3x4Hyp-GalHyl-COL10A1(?-680) [extracellular region] [EntityWithAccessionedSequence:R-HSA-2470539] COL10A1(?-680) [extracellular region] [EntityWithAccessionedSequence:R-HSA-2470538] GalHyl-COL10A1(19-?) [extracellular region] [EntityWithAccessionedSequence:R-HSA-2470516] GalHyl-COL10A1(?-680) [extracellular region] [EntityWithAccessionedSequence:R-HSA-2470518] COL10A1(19-?) [extracellular region] [EntityWithAccessionedSequence:R-HSA-2470512] 3x4Hyp-COL10A1(19-?) [extracellular region] [EntityWithAccessionedSequence:R-HSA-2470515] 3x4Hyp-GalHyl-COL10A1(19-?) [extracellular region] [EntityWithAccessionedSequence:R-HSA-2470525] 3x4Hyp-3Hyp-GlcGalHyl-COL10A1(19-?) [extracellular region] [EntityWithAccessionedSequence:R-HSA-2470524] 3x4Hyp-GlcGalHyl-COL10A1(?-680) [extracellular region] [EntityWithAccessionedSequence:R-HSA-2470527] GlcGalHyl-COL10A1(?-680) [extracellular region] [EntityWithAccessionedSequence:R-HSA-2470526] 3x4Hyp-3Hyp-GlcGalHyl-COL10A1(?-680) [extracellular region] [EntityWithAccessionedSequence:R-HSA-2470521] 3x4Hyp-3Hyp-COL10A1(19-?) [extracellular region] [EntityWithAccessionedSequence:R-HSA-2470522] 3x4Hyp-5Hyl-COL10A1(19-?) [extracellular region] [EntityWithAccessionedSequence:R-HSA-2173007] 5Hyl-COL10A1 [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-HSA-2173232] 3x4Hyp-3Hyp-5Hyl-COL10A1 [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-HSA-2173152] 3x4Hyp-5Hyl-COL10A1 [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-HSA-2172964] 3x4Hyp-3Hyp-COL10A1 [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-HSA-2172959] 3x4Hyp-COL10A1 [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-HSA-2172268] COL10A1 [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-HSA-2173168] 3x4Hyp-GalHyl-COL10A1 [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-HSA-2173104] GlcGalHyl-COL10A1 [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-HSA-2173191] 3x4Hyp-GlcGalHyl-COL10A1 [endoplasmic reticulum lumen]
(referenceSequence)	[ModifiedResidue:2172954] (2S,4R)-4-hydroxyproline at unknown position [ModifiedResidue:2172996] (2S,3S)-3-hydroxyproline at unknown position [ModifiedResidue:2173108] O5-glucosylgalactosyl-L-hydroxylysine at unknown position [ModifiedResidue:2173073] O5-galactosyl-L-hydroxylysine at unknown position [ModifiedResidue:2173029] (2S,5R)-5-hydroxylysine at unknown position
(interactor)	[UndirectedInteraction:11219291] UniProt:Q8N9N5 <-> UniProt:Q03692 (IntAct)

UniProt:Q03692 COL10A1 Show undefined attributes

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