Reactome | UniProt:Q03167 TGFBR3

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UniProt:Q03167 TGFBR3 Show undefined attributes

chain	signal peptide:1-20 chain:21-851
checksum	AEC56C4477C003B2
comment	FUNCTION Cell surface receptor that regulates diverse cellular processes including cell proliferation, differentiation, migration, and apoptosis (PubMed:12958365, PubMed:19416857). Initiates BMP, inhibin, and TGF-beta signaling pathways by interacting with different ligands including TGFB1, BMP2, BMP5, BMP7 or GDF5 (PubMed:18184661). Alternatively, acts as a cell surface coreceptor for BMP ligands, serving to enhance ligand binding by differentially regulating BMPR1A/ALK3 and BMPR1B/ALK6 receptor trafficking (PubMed:19726563). Promotes epithelial cell adhesion, focal adhesion formation and integrin signaling during epithelial cell spreading on fibronectin (PubMed:22562249). By interacting with the scaffolding protein beta-arrestin2/ARRB2, regulates migration or actin cytoskeleton and promotes the activation of CDC42 as well as the inhibition of NF-kappa-B (PubMed:19416857, PubMed:19325136). In gonadotrope cells, acts as an inhibin A coreceptor and regulates follicle-stimulating hormone (FSH) levels and female fertility (By similarity). Plays a role in the inhibition of directed and random cell migration in epithelial cells by altering the actin cytoskeletal organization (PubMed:19416857). Participates in epithelial-mesenchymal transformation (EMT) upon binding to BMP2 or TGFB2, by activating the PAR6/SMURF1/RHOA pathway (By similarity).FUNCTION (Microbial infection) May act as a receptor for human cytomegalovirus in different cell types by interacting with HCMV trimer composed of GO, GH and GL.SUBUNIT Forms homodimers and homooligomers (PubMed:11323414). Interacts with DYNLT4 (PubMed:16982625). Interacts with integrin ITGA5:ITGB1; this interaction promotes the internalization and trafficking of ITGA5:ITGB1 into endocytic vesicles (PubMed:22562249). Interacts with TGFB1, BMP2, BMP5, BMP7 or GDF5 and inhibin A via the ligand binding domains (PubMed:18184661). Interacts with ALK3/BMPR1A; this interaction results in the cell surface retention of BMPR1A (PubMed:19726563). Interacts with ALK6/BMPR1B; this interaction enhances BMPR1B-mediated stimulation of the BMP signaling pathway (PubMed:19726563). Interacts with the scaffolding protein beta-arrestin2/ARRB2; this interaction mediates internalization of TGFBR3 and thus regulates migration, actin cytoskeleton and activation of CDC42 (PubMed:12958365, PubMed:18184661, PubMed:19416857, PubMed:19325136).SUBUNIT (Microbial infection) Interacts with human cytomegalovirus trimer complex composed of gH, gL, and gO; these interactions may promote HCMV cell entry in specific cell types.INTERACTION Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix.ALTERNATIVE PRODUCTS Extensively modified by glycosaminoglycan groups (GAG).PTM Phosphorylated in the cytoplasmic domain by the type II receptor TGFBR2 at THR-840 to mediate recruitment of ARRB2 and subsequent internalization of TGFBR2 and TGFBR3.
crossReference	[DatabaseIdentifier:11460895] ENSEMBL:ENSG00000069702 [DatabaseIdentifier:11553969] ENSEMBL:ENSP00000432638 [DatabaseIdentifier:11553968] ENSEMBL:ENSP00000436127 [DatabaseIdentifier:11553971] ENSEMBL:ENSP00000212355 [DatabaseIdentifier:11553970] ENSEMBL:ENSP00000359426 [DatabaseIdentifier:11676670] ENSEMBL:ENST00000465892 [DatabaseIdentifier:11676667] ENSEMBL:ENST00000212355 [DatabaseIdentifier:11676669] ENSEMBL:ENST00000370399 [DatabaseIdentifier:11676668] ENSEMBL:ENST00000525962 [DatabaseIdentifier:11780736] Guide to Pharmacology - Targets:1796 [DatabaseIdentifier:11794256] GeneCards:TGFBR3 [DatabaseIdentifier:11810199] GlyGen:Q03167 [DatabaseIdentifier:11831210] HMDB Protein:HMDBP14563 [DatabaseIdentifier:11847235] HPA:ENSG00000069702-TGFBR3 [DatabaseIdentifier:12131906] OpenTargets:ENSG00000069702 [DatabaseIdentifier:12151046] PDB:7LBG [DatabaseIdentifier:12254285] PRO:Q03167 [DatabaseIdentifier:12292090] Pharos - Targets:Q03167 [DatabaseIdentifier:12342257] RefSeq:XP_047285212.1 [DatabaseIdentifier:12342251] RefSeq:NP_003234.2 [DatabaseIdentifier:12342250] RefSeq:NP_001182612.1 [DatabaseIdentifier:12342254] RefSeq:NP_001182613.1 [DatabaseIdentifier:12342255] RefSeq:XP_047285203.1 [DatabaseIdentifier:12342253] RefSeq:XP_047285210.1 [DatabaseIdentifier:12342249] RefSeq:XP_006710930.1 [DatabaseIdentifier:12342252] RefSeq:XP_047285227.1 [DatabaseIdentifier:12342256] RefSeq:XP_047285211.1 [DatabaseIdentifier:12342248] RefSeq:XP_047285217.1
databaseName	UniProt
dbId	65973
description	recommendedName: Transforming growth factor beta receptor type 3 shortName: TGF-beta receptor type 3 shortName: TGFR-3 alternativeName: Betaglycan alternativeName: Transforming growth factor beta receptor III shortName: TGF-beta receptor type III
displayName	UniProt:Q03167 TGFBR3
geneName	TGFBR3
identifier	Q03167
isSequenceChanged	false
keyword	3D-structure Alternative splicing Cell membrane Disulfide bond Extracellular matrix Glycoprotein Membrane Phosphoprotein Proteoglycan Proteomics identification Receptor Reference proteome Secreted Signal Transmembrane Transmembrane helix
modified	[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType	Protein
name	TGFBR3
otherIdentifier	11718900_a_at 11718901_at 11718902_a_at 16689546 1897_at 204731_PM_at 204731_at 226625_PM_at 226625_at 2422724 2422725 2422726 2422727 2422730 2422731 2422732 2422734 2422740 2422743 2422745 2422746 2422748 2422749 2422750 2422752 2422753 2422754 2422758 2422765 2422771 2422786 2422787 2422802 2422803 2422804 2422805 2422806 2422808 2422812 2422813 2422814 2422815 2422816 2422817 53793_at 7049 7917649 A_23_P200780 GE57580 GO:0001666 GO:0001837 GO:0001889 GO:0002376 GO:0003007 GO:0003150 GO:0003151 GO:0003223 GO:0003824 GO:0004888 GO:0005024 GO:0005114 GO:0005160 GO:0005515 GO:0005539 GO:0005576 GO:0005615 GO:0005829 GO:0005886 GO:0006955 GO:0007179 GO:0007181 GO:0008201 GO:0009897 GO:0009986 GO:0010628 GO:0015026 GO:0016020 GO:0016323 GO:0016477 GO:0016740 GO:0017015 GO:0017134 GO:0030154 GO:0030165 GO:0030336 GO:0030509 GO:0030511 GO:0030512 GO:0031100 GO:0032354 GO:0034673 GO:0034695 GO:0034699 GO:0035556 GO:0036122 GO:0043124 GO:0043235 GO:0046332 GO:0048185 GO:0048856 GO:0048870 GO:0050431 GO:0050680 GO:0055010 GO:0060038 GO:0060045 GO:0060216 GO:0060317 GO:0060318 GO:0060347 GO:0060391 GO:0060392 GO:0060412 GO:0060939 GO:0060979 GO:0061384 GO:0062009 GO:0065003 GO:0070062 GO:0070123 GO:0071560 GO:0071944 GO:0090050 GO:0090100 GO:0140096 GO:1901202 HMNXSV003004306 Hs.79059.1.S1_3p_at ILMN_1784287 L07594_at PH_hs_0016619 TC01002864.hg TC01005631.hg g4507470_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-9839336] TGFBR3_mem [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9839335] TGFBR3(21-851) [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9839380] TGFBR3(784-851) [basolateral plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9839374] TGFBR3 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9839364] pT841_TGFBR3 [plasma membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000069702] ENSEMBL:ENSG00000069702 TGFBR3 [ReferenceDNASequence:12678746] UCSC:Q03167 TGFBR3 [ReferenceDNASequence:11325410] BioGPS Gene:7049 TGFBR3 [ReferenceDNASequence:11391986] COSMIC - genes:TGFBR3 TGFBR3 [ReferenceDNASequence:11422965] CTD Gene:7049 TGFBR3 [ReferenceDNASequence:11427720] dbSNP Gene:7049 TGFBR3 [ReferenceDNASequence:11825951] HGNC:11774 TGFBR3 [ReferenceDNASequence:11867816] KEGG:hsa:7049 TGFBR3 [ReferenceDNASequence:11955199] Monarch:7049 TGFBR3 [ReferenceDNASequence:12039292] NCBI Gene:7049 TGFBR3 [ReferenceDNASequence:12116317] OMIM:600742 TGFBR3
referenceTranscript	[ReferenceRNASequence:12524134] RefSeq:XM_047429247.1 TGFBR3 [ReferenceRNASequence:12524138] RefSeq:NM_003243.5 TGFBR3 [ReferenceRNASequence:12524139] RefSeq:XM_047429261.1 TGFBR3 [ReferenceRNASequence:12524132] RefSeq:NM_001195684.1 TGFBR3 [ReferenceRNASequence:12524140] RefSeq:XM_047429271.1 TGFBR3 [ReferenceRNASequence:12524137] RefSeq:XM_047429254.1 TGFBR3 [ReferenceRNASequence:12524136] RefSeq:XM_047429255.1 TGFBR3 [ReferenceRNASequence:12524135] RefSeq:XM_006710867.3 TGFBR3 [ReferenceRNASequence:12524131] RefSeq:NM_001195683.2 TGFBR3 [ReferenceRNASequence:12524133] RefSeq:XM_047429256.1 TGFBR3
schemaClass	ReferenceGeneProduct
secondaryIdentifier	TGBR3_HUMAN A0AUW8 A8K5N0 B9EG88 Q5T2T4 Q5U731 Q9UGI2
sequenceLength	851
species	[Species:48887] Homo sapiens
stId	uniprot:Q03167
url	http://purl.uniprot.org/uniprot/Q03167

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-9839336] TGFBR3_mem [plasma membrane] [EntityWithAccessionedSequence:R-HSA-9839335] TGFBR3(21-851) [extracellular region] [EntityWithAccessionedSequence:R-HSA-9839380] TGFBR3(784-851) [basolateral plasma membrane] [EntityWithAccessionedSequence:R-HSA-9839374] TGFBR3 [cytosol] [EntityWithAccessionedSequence:R-HSA-9839364] pT841_TGFBR3 [plasma membrane]
(interactor)	[UndirectedInteraction:11129937] UniProt:Q03167 <-> UniProt:P22455 (IntAct) [UndirectedInteraction:11129941] UniProt:Q03167 <-> UniProt:Q8NCB2 (IntAct) [UndirectedInteraction:11129943] UniProt:Q03167 <-> UniProt:O14908 (IntAct)