FUNCTION Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling.SUBCELLULAR LOCATION Additional isoforms seem to exist.TISSUE SPECIFICITY Broad specificity; small intestine, colon, colonic tumors, heart, liver, thymus, prostate, pancreas and gall bladder.PTM Highly O-glycosylated and probably also N-glycosylated.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.SEQUENCE CAUTION This sequence is incomplete at 5' and 3' ends and extensively differs from that shown.SEQUENCE CAUTION This sequence is incomplete at 5' and 3' ends and extensively differs from that shown.
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