Reactome | UniProt:Q00623 Apoa1

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UniProt:Q00623 Apoa1 Show undefined attributes

chain	signal peptide:1-18 chain:19-264 chain:25-264 chain:25-263
checksum	5E33FF201963583B
comment	FUNCTION Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.SUBUNIT Homodimer (By similarity). Interacts with APOA1BP and CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin. Interacts with NDRG1. Interacts with SCGB3A2 (By similarity). Interacts with NAXE and YJEFN3 (By similarity).INTERACTION Major protein of plasma HDL, also found in chylomicrons.PTM Glycosylated.PTM Palmitoylated.PTM May be acylated.PTM Phosphorylation sites are present in the extracellular medium.MASS SPECTROMETRY Strain C57BL/6. Without methionine sulfoxide.MASS SPECTROMETRY Strain BALB/c. Without methionine sulfoxide.MASS SPECTROMETRY Strain C57BL/6. With 1 methionine sulfoxide.MASS SPECTROMETRY Strain C57BL/6. Without methionine sulfoxide.MASS SPECTROMETRY Strain BALB/c. Without methionine sulfoxide.SIMILARITY Belongs to the apolipoprotein A1/A4/E family.
crossReference	[DatabaseIdentifier:12405478] RefSeq:NP_033822.2 [DatabaseIdentifier:12241431] PRO:Q00623 [DatabaseIdentifier:12164073] PDB:2LEM [DatabaseIdentifier:11931598] MGI:88049 [DatabaseIdentifier:11716943] ENSEMBL:ENSMUST00000034588 [DatabaseIdentifier:11594244] ENSEMBL:ENSMUSP00000034588 [DatabaseIdentifier:11488715] ENSEMBL:ENSMUSG00000032083
databaseName	UniProt
dbId	85104
description	recommendedName: Apolipoprotein A-I shortName: Apo-AI shortName: ApoA-I alternativeName: Apolipoprotein A1 component recommendedName: Proapolipoprotein A-I shortName: ProapoA-I /component component recommendedName: Truncated apolipoprotein A-I /component
displayName	UniProt:Q00623 Apoa1
geneName	Apoa1
identifier	Q00623
isSequenceChanged	false
keyword	3D-structure Cholesterol metabolism Direct protein sequencing Glycoprotein HDL Lipid metabolism Lipid transport Lipoprotein Oxidation Palmitate Phosphoprotein Reference proteome Repeat Secreted Signal Steroid metabolism Sterol metabolism Transport
modified	[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType	Protein
name	Apoa1
otherIdentifier	10585005 11806 1419232_a_at 1419233_x_at 1438840_x_at 1455201_x_at 17516901 4515990 4750115 4790258 5179074 5186558 5297394 5306000 5390952 5415898 5442851 96094_at A_51_P408082 GE35080 GO:0001540 GO:0001935 GO:0002719 GO:0005102 GO:0005215 GO:0005319 GO:0005515 GO:0005543 GO:0005576 GO:0005615 GO:0005829 GO:0006629 GO:0006644 GO:0006656 GO:0006695 GO:0006869 GO:0007186 GO:0007229 GO:0008035 GO:0008202 GO:0008203 GO:0008211 GO:0008289 GO:0010804 GO:0010875 GO:0010903 GO:0015485 GO:0018158 GO:0018206 GO:0019899 GO:0019915 GO:0030139 GO:0030300 GO:0030301 GO:0030325 GO:0031072 GO:0031410 GO:0032489 GO:0032691 GO:0033344 GO:0033700 GO:0034115 GO:0034190 GO:0034191 GO:0034205 GO:0034361 GO:0034362 GO:0034364 GO:0034366 GO:0034375 GO:0034380 GO:0035025 GO:0042157 GO:0042158 GO:0042627 GO:0042632 GO:0042802 GO:0042803 GO:0043226 GO:0043534 GO:0043691 GO:0045499 GO:0048018 GO:0048856 GO:0048870 GO:0050728 GO:0050766 GO:0050821 GO:0050919 GO:0051180 GO:0051496 GO:0055090 GO:0055091 GO:0060228 GO:0060354 GO:0060761 GO:0065003 GO:0070328 GO:0070508 GO:0070653 GO:0071402 GO:0071813 GO:0090205 GO:0098772 GO:0120020 GO:1900026 GO:1902995 GO:1903561 GO:1904646 ILMN_2623393 Msa.43196.0_at mMC020418
physicalEntity	[EntityWithAccessionedSequence:R-MMU-2425413] Apoa1 [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-MMU-2395781] Apoa1 [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-MMU-2429641] Apoa1 [early endosome] - Mus musculus [EntityWithAccessionedSequence:R-MMU-350761] Apoa1 [secretory granule lumen] - Mus musculus [EntityWithAccessionedSequence:R-MMU-174640] Apoa1 [endoplasmic reticulum lumen] - Mus musculus [EntityWithAccessionedSequence:R-MMU-264771] Apoa1 [extracellular region] - Mus musculus [EntityWithAccessionedSequence:R-MMU-216742] Apoa1 [plasma membrane] - Mus musculus [EntityWithAccessionedSequence:R-MMU-2425419] Apoa1 [extracellular region] - Mus musculus [EntityWithAccessionedSequence:R-MMU-2239460] Apoa1 [endocytic vesicle lumen] - Mus musculus [EntityWithAccessionedSequence:R-MMU-8957081] phospho-Apoa1 [endoplasmic reticulum lumen] - Mus musculus [EntityWithAccessionedSequence:R-MMU-8956724] Apoa1 [endoplasmic reticulum lumen] - Mus musculus [EntityWithAccessionedSequence:R-MMU-174720] Apoa1 [extracellular region] - Mus musculus
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12747532] UCSC:Q00623 Apoa1 [ReferenceDNASequence:12067885] NCBI Gene:11806 Apoa1 [ReferenceDNASequence:11983792] Monarch:11806 Apoa1 [ReferenceDNASequence:11893587] KEGG:mmu:11806 Apoa1 [ReferenceDNASequence:11354003] BioGPS Gene:11806 Apoa1
referenceTranscript	[ReferenceRNASequence:12587181] RefSeq:NM_009692.4 Apoa1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	APOA1_MOUSE O08855 O09042 Q8BPD5
sequenceLength	264
species	[Species:48892] Mus musculus
stId	uniprot:Q00623
url	http://purl.uniprot.org/uniprot/Q00623

Referrals

(interactor)	[UndirectedInteraction:11203363] UniProt:Q00623 <-> UniProt:Q08460 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-MMU-2425413] Apoa1 [cytosol] [EntityWithAccessionedSequence:R-MMU-2395781] Apoa1 [cytosol] [EntityWithAccessionedSequence:R-MMU-2429641] Apoa1 [early endosome] [EntityWithAccessionedSequence:R-MMU-350761] Apoa1 [secretory granule lumen] [EntityWithAccessionedSequence:R-MMU-174640] Apoa1 [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-MMU-264771] Apoa1 [extracellular region] [EntityWithAccessionedSequence:R-MMU-216742] Apoa1 [plasma membrane] [EntityWithAccessionedSequence:R-MMU-2425419] Apoa1 [extracellular region] [EntityWithAccessionedSequence:R-MMU-2239460] Apoa1 [endocytic vesicle lumen] [EntityWithAccessionedSequence:R-MMU-8957081] phospho-Apoa1 [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-MMU-8956724] Apoa1 [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-MMU-174720] Apoa1 [extracellular region]
(referenceSequence)	[ModifiedResidue:10083253] phosphorylated residue at unknown position