UniProt:Q00196 Pou2f2

chain
  • chain:1-463
checksum B6669B5885ABD789
comment
  • FUNCTION Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3') (PubMed:1281152, PubMed:2011512). Regulates IL6 expression in B cells with POU2AF1 (PubMed:23045607). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR.FUNCTION Activates octamer-containing promoters.FUNCTION Activates octamer-containing promoters.FUNCTION Activates octamer-containing promoters.FUNCTION Represses some promoters and activate others.FUNCTION Represses some promoters and activate others (PubMed:1281152, PubMed:2011512). Activates the U2 small nuclear RNA (snRNA) promoter (By similarity).FUNCTION Unable to bind to the octamer motif, but can still activate the beta-casein gene promoter at low levels.ACTIVITY REGULATION Transactivation activity is enhanced by transcriptional coactivator POU2AF1.SUBUNIT Interacts with NR3C1, AR and PGR. Interacts with POU2AF1; the interaction increases POU2F2 transactivation activity.SUBCELLULAR LOCATION In alveolus epithelial cells of mammary glands, present in the nucleus and cytoplasm. In HC11 mammary epithelial cells, present in the nucleus and preinuclear regions.ALTERNATIVE PRODUCTS Additional isoforms seem to exist.TISSUE SPECIFICITY Highest in B cells, but also present in brain (neuronal and glial cells), intestine, kidney, and testes.TISSUE SPECIFICITY Expressed at higher levels in B-cells than in neuronal cells.TISSUE SPECIFICITY Expressed in neuronal cell lines and brain, but not dorsal root ganglia.TISSUE SPECIFICITY Expressed at lower levels in neuronal cells than in B cells.TISSUE SPECIFICITY Expressed in neuronal cell lines, and at lower levels in neuroblastoma and dorsal root ganglia.TISSUE SPECIFICITY Widely expressed in the developing nervous system but expression is confined to very specific regions in the adult brain, it is expressed at a lower level in B cells.TISSUE SPECIFICITY Either absent in, or expressed at very low levels in neuronal cells and brain.TISSUE SPECIFICITY Expressed in all tissues tested: mammary gland, liver, spleen, lung, kidney intestine, uterus and ovary of a virgin mouse. Levels of isoform OCT2.7 are highest in spleen and lung. In mammary gland, expression is localized to the alveolus epithelial cells.DEVELOPMENTAL STAGE Widely but not homogeneously expressed in developing nervous system. Expression levels in mammary glands are barely detectable in virgin mice, levels increase during pregnancy, reaching a maximum during late pregnancy, then decrease during lactation becoming very low post-lactation.INDUCTION In B cells, expression is highly increased upon activation by LPS or CpG.DISRUPTION PHENOTYPE Mutants show normal development of germinal center B cells when infected by influenza virus.MISCELLANEOUS The isoform OCT2b described in PubMed:7888080 corresponds to the isoform OCT2a of PubMed:1976089. To avoid any confusion, we use the nomenclature from PubMed:2011512 to describe the different isoforms.MISCELLANEOUS The isoform OCT2b described in PubMed:7888080 corresponds to the isoform OCT2a of PubMed:1976089. To avoid any confusion, we use the nomenclature from PubMed:2011512 to describe the different isoforms.SIMILARITY Belongs to the POU transcription factor family. Class-2 subfamily.SEQUENCE CAUTION Truncated N-terminus.
crossReference
databaseName UniProt
dbId 98599
description
  • recommendedName: fullName evidence="15"POU domain, class 2, transcription factor 2 alternativeName: Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2 alternativeName: Octamer-binding protein 2 shortName: Oct-2 alternativeName: Octamer-binding transcription factor 2 shortName: OTF-2
displayName UniProt:Q00196 Pou2f2
geneName
  • Pou2f2
  • Oct2
  • Otf2
identifier Q00196
isSequenceChanged false
keyword
  • Activator
  • Alternative splicing
  • Cytoplasm
  • DNA-binding
  • Homeobox
  • Nucleus
  • Reference proteome
  • Transcription
  • Transcription regulation
modified [InstanceEdit:9917590] Weiser, Joel, 2024-08-09
moleculeType Protein
name
  • Pou2f2
otherIdentifier
  • 10560964
  • 109527_at
  • 1427713_x_at
  • 1427725_a_at
  • 1443885_at
  • 17487855
  • 18987
  • 4346134
  • 4394220
  • 4422533
  • 4443904
  • 4458593
  • 4465068
  • 4468229
  • 4596730
  • 4636442
  • 4641315
  • 4643390
  • 4647081
  • 4755180
  • 4817559
  • 4869592
  • 4905145
  • 4986984
  • 4997628
  • 5025400
  • 5068041
  • 5068913
  • 5073534
  • 5107909
  • 5184959
  • 5190569
  • 5220382
  • 5316160
  • 5359304
  • 5397557
  • 5443553
  • 5510514
  • 5532673
  • 5538562
  • 5584179
  • 5602023
  • 92305_s_at
  • A_51_P166728
  • A_51_P444795
  • A_55_P2057877
  • A_66_P121353
  • GE1398638
  • GE35923
  • GO:0000976
  • GO:0000978
  • GO:0000981
  • GO:0001228
  • GO:0002335
  • GO:0002376
  • GO:0003677
  • GO:0003700
  • GO:0005634
  • GO:0005654
  • GO:0005737
  • GO:0006355
  • GO:0006357
  • GO:0015606
  • GO:0015848
  • GO:0019904
  • GO:0030154
  • GO:0032755
  • GO:0043565
  • GO:0045893
  • GO:0045944
  • GO:0048469
  • GO:0055085
  • GO:0098586
  • GO:1903711
  • ILMN_2687602
  • mMC011511
  • x53654_s_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • PO2F2_MOUSE
  • Q00197
  • Q00198
  • Q00199
  • Q00200
  • Q00201
  • Q05882
  • Q3KR47
  • Q3U127
  • Q5XML1
  • Q5XML2
  • Q61995
  • Q61996
  • Q64245
sequenceLength 463
species [Species:48892] Mus musculus
stId uniprot:Q00196
url http://purl.uniprot.org/uniprot/Q00196
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