Reactome | UniProt:P98077 SHC2

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UniProt:P98077 SHC2 Show undefined attributes

chain	chain:1-582
checksum	F640AC298DA37B68
comment	FUNCTION Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity).SUBUNIT Interacts with the Trk receptors in a phosphotyrosine-dependent manner and MEGF12. Once activated, binds to GRB2.INTERACTION Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.DOMAIN The PID domain mediates binding to the TrkA receptor.PTM Phosphorylated on tyrosines by the Trk receptors.MISCELLANEOUS PubMed:15057824 has shown that SHC2 is poorly phosphorylated by the Trk receptors, in opposite to PubMed:12006576.
crossReference	[DatabaseIdentifier:12816687] ZINC target:P98077 [DatabaseIdentifier:12813284] ZINC - Substances:SHC2_HUMAN [DatabaseIdentifier:12447407] RefSeq:NP_036567.2 [DatabaseIdentifier:12282818] Pharos - Targets:P98077 [DatabaseIdentifier:12261089] PRO:P98077 [DatabaseIdentifier:12122497] OpenTargets:ENSG00000129946 [DatabaseIdentifier:11837996] HPA:ENSG00000129946-SHC2 [DatabaseIdentifier:11784906] GeneCards:SHC2 [DatabaseIdentifier:11746094] ENSEMBL:ENST00000264554 [DatabaseIdentifier:11623395] ENSEMBL:ENSP00000264554 [DatabaseIdentifier:11508970] ENSEMBL:ENSG00000129946
databaseName	UniProt
dbId	64208
description	recommendedName: SHC-transforming protein 2 alternativeName: Protein Sck alternativeName: SHC-transforming protein B alternativeName: Src homology 2 domain-containing-transforming protein C2 shortName: SH2 domain protein C2
displayName	UniProt:P98077 SHC2
geneName	SHC2 SCK SHCB
identifier	P98077
isSequenceChanged	false
keyword	Phosphoprotein Proteomics identification Reference proteome SH2 domain
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	SHC2
otherIdentifier	11728145_a_at 16866435 213464_PM_at 213464_at 25759 35622_at 3844568 3844569 3844570 3844572 3844573 3844576 3844580 3844581 3844582 3844583 3844585 3844586 3844587 3844588 3844589 3844600 3844601 3844602 8032037 A_32_P205624 A_33_P3318606 GE53025 GO:0005515 GO:0005829 GO:0005886 GO:0007169 GO:0030971 GO:0035556 HMNXSV003024969 HMNXSV003031939 HMNXSV003041270 Hs.30965.0.A1_3p_at ILMN_1683857 ILMN_1721087 ILMN_1734667 PH_hs_0037093 RNA94954\|RNS_36_198 TC19000985.hg
physicalEntity	[EntityWithAccessionedSequence:R-HSA-167050] SHC2 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-167051] p-Y-SHC2 [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12708163] UCSC:P98077 SHC2 [ReferenceDNASequence:12108103] OMIM:605217 SHC2 [ReferenceDNASequence:12087770] NCBI Gene:25759 SHC2 [ReferenceDNASequence:12003677] Monarch:25759 SHC2 [ReferenceDNASequence:11911662] KEGG:hsa:25759 SHC2 [ReferenceDNASequence:11816531] HGNC:29869 SHC2 [ReferenceDNASequence:11431656] dbSNP Gene:25759 SHC2 [ReferenceDNASequence:11409097] CTD Gene:25759 SHC2 [ReferenceDNASequence:11395431] COSMIC - genes:SHC2 SHC2 [ReferenceDNASequence:11373888] BioGPS Gene:25759 SHC2 [ReferenceDNASequence:ensembl:ENSG00000129946] ENSEMBL:ENSG00000129946 SHC2
referenceTranscript	[ReferenceRNASequence:12628957] RefSeq:NM_012435.3 SHC2
schemaClass	ReferenceGeneProduct
secondaryIdentifier	SHC2_HUMAN O60230 Q9NPL5 Q9UCX4
sequenceLength	582
species	[Species:48887] Homo sapiens
stId	uniprot:P98077
url	http://purl.uniprot.org/uniprot/P98077

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-167050] SHC2 [cytosol] [EntityWithAccessionedSequence:R-HSA-167051] p-Y-SHC2 [cytosol]
(referenceSequence)	[ModifiedResidue:167011] O4'-phospho-L-tyrosine at unknown position