UniProt:P87108 TIM10

chain
  • chain:1-93
checksum 70DD4764B944FF17
comment
  • FUNCTION Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. Compared to TIM9, it may function as a substrate sensor.SUBUNIT Heterohexamer; composed of 3 copies of TIM9 and 3 copies of TIM10, named soluble 70 kDa complex. Associates directly with the TIM12 component of the TIM22 complex, whose core is composed of TIM18, TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit.INTERACTION The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIM10 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane.SIMILARITY Belongs to the small Tim family.
crossReference
databaseName UniProt
dbId 93116
description
  • recommendedName: Mitochondrial import inner membrane translocase subunit TIM10 alternativeName: Mitochondrial intermembrane protein MRS11
displayName UniProt:P87108 TIM10
geneName
  • TIM10
  • MRS11
  • YHR005C-A
  • YHR005BC
identifier P87108
isSequenceChanged false
keyword
  • 3D-structure
  • Chaperone
  • Direct protein sequencing
  • Disulfide bond
  • Membrane
  • Metal-binding
  • Mitochondrion
  • Mitochondrion inner membrane
  • Protein transport
  • Reference proteome
  • Translocation
  • Transport
  • Zinc
modified [InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType Protein
name
  • TIM10
otherIdentifier
  • 856395
  • GO:0003674
  • GO:0005515
  • GO:0005575
  • GO:0005739
  • GO:0005743
  • GO:0005758
  • GO:0008150
  • GO:0008270
  • GO:0015031
  • GO:0016020
  • GO:0042719
  • GO:0042721
  • GO:0043167
  • GO:0045039
  • GO:0046872
  • GO:0051082
  • GO:0140318
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • TIM10_YEAST
  • D3DKU9
sequenceLength 93
species [Species:68322] Saccharomyces cerevisiae
stId uniprot:P87108
url http://purl.uniprot.org/uniprot/P87108
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