Reactome | UniProt:P84233 Unknown

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UniProt:P84233 Unknown Show undefined attributes

chain	initiator methionine:1 chain:2-136
checksum	6FD8508EA50A0EEC
comment	FUNCTION Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.SUBUNIT The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.INTERACTION Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.PTM Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).PTM Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by prmt6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).PTM Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for tp53bp1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (cbx1, cbx3 and cbx5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).PTM Phosphorylated at Thr-4 (H3T3ph) by VRK1 (By similarity). Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by aurkb mediates the dissociation of HP1 proteins (cbx1, cbx3 and cbx5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by map3k20 isoform 1, rps6ka5 or aurkb during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by prkcb is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by lsd1/kdm1a. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by kdm4c/jmjd2c. Phosphorylation at Tyr-42 (H3Y41ph) by jak2 promotes exclusion of cbx5 (HP1 alpha) from chromatin (By similarity).PTM Monoubiquitinated at Lys-15 (H3K14ub), Lys-19 (H3K18ub) and Lys-24 (H3K23ub) by UHRF1 and HLTF at hemimethylated DNA sites following DNA replication, promoting recruitment of DNMT1 DNA methyltransferase and replication-coupled DNA methylation maintenance (By similarity). Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination (By similarity).PTM Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.PTM Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.PTM Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.PTM Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).PTM Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).PTM Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).PTM Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.SIMILARITY Belongs to the histone H3 family.
created	[InstanceEdit:4549218] Jupe, S, 2013-09-11
crossReference	[DatabaseIdentifier:12165956] PDB:7KBE [DatabaseIdentifier:12793035] Xenbase:XB-GENE-866635 [DatabaseIdentifier:12456175] RefSeq:XP_018118226.1 [DatabaseIdentifier:12456182] RefSeq:XP_018098036.1 [DatabaseIdentifier:12456177] RefSeq:XP_041444756.1 [DatabaseIdentifier:12456180] RefSeq:XP_041434998.1 [DatabaseIdentifier:12456173] RefSeq:XP_018118227.1 [DatabaseIdentifier:12456181] RefSeq:XP_041434999.1 [DatabaseIdentifier:12456185] RefSeq:XP_041434997.1 [DatabaseIdentifier:12456184] RefSeq:XP_041432548.1 [DatabaseIdentifier:12456176] RefSeq:XP_018079657.1 [DatabaseIdentifier:12456179] RefSeq:XP_018096296.1 [DatabaseIdentifier:12456174] RefSeq:XP_041420127.1 [DatabaseIdentifier:12456178] RefSeq:XP_041432550.1 [DatabaseIdentifier:12456183] RefSeq:XP_041418540.1 [DatabaseIdentifier:12166137] PDB:8PEP [DatabaseIdentifier:12166102] PDB:3REI [DatabaseIdentifier:12166125] PDB:3MNN [DatabaseIdentifier:12166092] PDB:5O9G [DatabaseIdentifier:12166148] PDB:5OMX [DatabaseIdentifier:12166116] PDB:7XFM [DatabaseIdentifier:12160104] PDB:8V27 [DatabaseIdentifier:12160353] PDB:6VEN [DatabaseIdentifier:12166113] PDB:5F99 [DatabaseIdentifier:12154603] PDB:7VDV [DatabaseIdentifier:12160101] PDB:7UD5 [DatabaseIdentifier:12141487] PDB:7YI5 [DatabaseIdentifier:12166124] PDB:1F66 [DatabaseIdentifier:12166115] PDB:8SIY [DatabaseIdentifier:12166091] PDB:8PC5 [DatabaseIdentifier:12160106] PDB:8V25 [DatabaseIdentifier:12166141] PDB:5Z3L [DatabaseIdentifier:12166106] PDB:6ESI [DatabaseIdentifier:12163607] PDB:7X3W [DatabaseIdentifier:12139636] PDB:6VYP [DatabaseIdentifier:12166123] PDB:7XFJ [DatabaseIdentifier:12166096] PDB:6JM9 [DatabaseIdentifier:12166132] PDB:8SKZ [DatabaseIdentifier:12166122] PDB:7XFI [DatabaseIdentifier:12166086] PDB:3B6F [DatabaseIdentifier:12141479] PDB:8IHN [DatabaseIdentifier:12166110] PDB:3REL [DatabaseIdentifier:12166129] PDB:4YS3 [DatabaseIdentifier:12166147] PDB:7OH9 [DatabaseIdentifier:12147012] PDB:7OTQ [DatabaseIdentifier:12166112] PDB:6S01 [DatabaseIdentifier:12160071] PDB:6O96 [DatabaseIdentifier:12166149] PDB:4Z66 [DatabaseIdentifier:12166088] PDB:1ZLA [DatabaseIdentifier:12140164] PDB:8BZ1 [DatabaseIdentifier:12166146] PDB:5HQ2 [DatabaseIdentifier:12166126] PDB:6WZ5 [DatabaseIdentifier:12166144] PDB:5ONG [DatabaseIdentifier:12166081] PDB:3LZ0 [DatabaseIdentifier:12163603] PDB:7X3T [DatabaseIdentifier:12166134] PDB:7MBN [DatabaseIdentifier:12148647] PDB:8A3Y [DatabaseIdentifier:12166130] PDB:5NL0 [DatabaseIdentifier:12140162] PDB:8BYQ [DatabaseIdentifier:12178127] PDB:5BSA [DatabaseIdentifier:12178125] PDB:2HUE [DatabaseIdentifier:12160110] PDB:8V28 [DatabaseIdentifier:12166143] PDB:7OHC [DatabaseIdentifier:12160103] PDB:8V26 [DatabaseIdentifier:12166108] PDB:3REK [DatabaseIdentifier:12166104] PDB:7TN2 [DatabaseIdentifier:12166135] PDB:8PEO [DatabaseIdentifier:12166085] PDB:7XFC [DatabaseIdentifier:12166082] PDB:8GPN [DatabaseIdentifier:12178124] PDB:9B2U [DatabaseIdentifier:12141478] PDB:8IHM [DatabaseIdentifier:12178126] PDB:6NE3 [DatabaseIdentifier:12166109] PDB:6ESH [DatabaseIdentifier:12166103] PDB:6ESF [DatabaseIdentifier:12166097] PDB:3KXB [DatabaseIdentifier:12163604] PDB:7X3X [DatabaseIdentifier:12166117] PDB:7XFN [DatabaseIdentifier:12141490] PDB:7YI4 [DatabaseIdentifier:12166145] PDB:7OHA [DatabaseIdentifier:12141481] PDB:7YI1 [DatabaseIdentifier:12139342] PDB:6TDA [DatabaseIdentifier:12166105] PDB:3REJ [DatabaseIdentifier:12166142] PDB:7OHB [DatabaseIdentifier:12166128] PDB:4KGC [DatabaseIdentifier:12166121] PDB:7XFL [DatabaseIdentifier:12141470] PDB:8JHO [DatabaseIdentifier:12166120] PDB:7XFH [DatabaseIdentifier:12166100] PDB:9QAJ [DatabaseIdentifier:12166087] PDB:3LJA [DatabaseIdentifier:12159242] PDB:8G57 [DatabaseIdentifier:12160081] PDB:4ZUX [DatabaseIdentifier:12166093] PDB:8PC6 [DatabaseIdentifier:12141244] PDB:2L12 [DatabaseIdentifier:12166133] PDB:7VDT [DatabaseIdentifier:12141472] PDB:8IHT [DatabaseIdentifier:12166140] PDB:7VVU [DatabaseIdentifier:12166099] PDB:6ESG [DatabaseIdentifier:12178129] PDB:2L11 [DatabaseIdentifier:12178128] PDB:5BS7 [DatabaseIdentifier:12166090] PDB:8CZE [DatabaseIdentifier:12166119] PDB:7EA5 [DatabaseIdentifier:12160055] PDB:6JMA [DatabaseIdentifier:12166098] PDB:3REH [DatabaseIdentifier:12166118] PDB:3B6G [DatabaseIdentifier:12166138] PDB:7MBM [DatabaseIdentifier:12166136] PDB:6WZ9 [DatabaseIdentifier:12166084] PDB:7X3V [DatabaseIdentifier:12166057] PDB:4LD9 [DatabaseIdentifier:12166059] PDB:6PWV [DatabaseIdentifier:12160288] PDB:8SVF [DatabaseIdentifier:12166032] PDB:6KIX [DatabaseIdentifier:12160248] PDB:7K6Q [DatabaseIdentifier:12166052] PDB:9NH8 [DatabaseIdentifier:12166048] PDB:3MGP [DatabaseIdentifier:12178120] PDB:6Z6P [DatabaseIdentifier:12166010] PDB:7XNP [DatabaseIdentifier:12166073] PDB:3LZ1 [DatabaseIdentifier:12166053] PDB:3KUY [DatabaseIdentifier:12166017] PDB:8T3Y [DatabaseIdentifier:12166075] PDB:6W5I [DatabaseIdentifier:12166072] PDB:6W5N [DatabaseIdentifier:12166031] PDB:6KIV [DatabaseIdentifier:12166028] PDB:3TU4 [DatabaseIdentifier:12166042] PDB:1P3L [DatabaseIdentifier:12166029] PDB:6KIU [DatabaseIdentifier:12147010] PDB:6ZHY [DatabaseIdentifier:12166030] PDB:6KIW [DatabaseIdentifier:12166078] PDB:9B2T [DatabaseIdentifier:12166037] PDB:1P3F [DatabaseIdentifier:12166049] PDB:3MGQ [DatabaseIdentifier:12159705] PDB:3MVD [DatabaseIdentifier:12166070] PDB:8THU [DatabaseIdentifier:12166018] PDB:8T3W [DatabaseIdentifier:12166069] PDB:8CWW [DatabaseIdentifier:12148642] PDB:7UND [DatabaseIdentifier:12166020] PDB:7SWY [DatabaseIdentifier:12166056] PDB:6IY3 [DatabaseIdentifier:12166041] PDB:1P3M [DatabaseIdentifier:12141499] PDB:8KD6 [DatabaseIdentifier:12166015] PDB:5DNN [DatabaseIdentifier:12166039] PDB:1P3O [DatabaseIdentifier:12166038] PDB:1P3P [DatabaseIdentifier:12153426] PDB:5E5A [DatabaseIdentifier:12149220] PDB:6RYR [DatabaseIdentifier:12166035] PDB:1P3I [DatabaseIdentifier:12160246] PDB:7K6P [DatabaseIdentifier:12141497] PDB:8KD5 [DatabaseIdentifier:12147008] PDB:7ENN [DatabaseIdentifier:12166016] PDB:5DNM [DatabaseIdentifier:12166063] PDB:6PWX [DatabaseIdentifier:12166012] PDB:6NOG [DatabaseIdentifier:12166033] PDB:6KIZ [DatabaseIdentifier:12166077] PDB:8T9H [DatabaseIdentifier:12166067] PDB:8RUQ [DatabaseIdentifier:12166036] PDB:1P3G [DatabaseIdentifier:12166061] PDB:5OXV [DatabaseIdentifier:12149211] PDB:6RYU [DatabaseIdentifier:12148641] PDB:7UNC [DatabaseIdentifier:12166023] PDB:8UXQ [DatabaseIdentifier:12149315] PDB:7NKY [DatabaseIdentifier:12149313] PDB:7NKX [DatabaseIdentifier:12166009] PDB:6X0N [DatabaseIdentifier:12141494] PDB:8KD7 [DatabaseIdentifier:12166026] PDB:7XPX [DatabaseIdentifier:12141098] PDB:8UW1 [DatabaseIdentifier:12160250] PDB:9DBY [DatabaseIdentifier:12166007] PDB:8F86 [DatabaseIdentifier:12166045] PDB:3LEL [DatabaseIdentifier:12166034] PDB:1P3K [DatabaseIdentifier:12145634] PDB:8CEO [DatabaseIdentifier:12165183] PDB:8T9G [DatabaseIdentifier:12166022] PDB:6FQ6 [DatabaseIdentifier:12166005] PDB:2NZD [DatabaseIdentifier:12166062] PDB:5OY7 [DatabaseIdentifier:12141492] PDB:8KD4 [DatabaseIdentifier:12166080] PDB:8T9F [DatabaseIdentifier:12166027] PDB:7AT8 [DatabaseIdentifier:12166044] PDB:1P34 [DatabaseIdentifier:12166013] PDB:5XF6 [DatabaseIdentifier:12166024] PDB:6FQ5 [DatabaseIdentifier:12178122] PDB:3C1C [DatabaseIdentifier:12166079] PDB:9DGG [DatabaseIdentifier:12145622] PDB:7ZS9 [DatabaseIdentifier:12166008] PDB:6NN6 [DatabaseIdentifier:12160269] PDB:9DDE [DatabaseIdentifier:12149345] PDB:6I84 [DatabaseIdentifier:12166047] PDB:1P3A [DatabaseIdentifier:12166076] PDB:9B2S [DatabaseIdentifier:12166046] PDB:1P3B [DatabaseIdentifier:12166014] PDB:7YRG [DatabaseIdentifier:12166019] PDB:4XZQ [DatabaseIdentifier:12178123] PDB:6O22 [DatabaseIdentifier:12141493] PDB:8KD2 [DatabaseIdentifier:12166068] PDB:8RUP [DatabaseIdentifier:12166064] PDB:6PWW [DatabaseIdentifier:12166055] PDB:5CP6 [DatabaseIdentifier:12166058] PDB:6IY2 [DatabaseIdentifier:12166051] PDB:3MGS [DatabaseIdentifier:12178121] PDB:3C1B [DatabaseIdentifier:12160267] PDB:6NQA [DatabaseIdentifier:12166006] PDB:2FJ7 [DatabaseIdentifier:12160298] PDB:9DG3 [DatabaseIdentifier:12140170] PDB:8BVW [DatabaseIdentifier:12147011] PDB:6ZHX [DatabaseIdentifier:12166050] PDB:3MGR [DatabaseIdentifier:12166074] PDB:3KWQ [DatabaseIdentifier:12166071] PDB:6W5M [DatabaseIdentifier:12165994] PDB:9E1L [DatabaseIdentifier:12165997] PDB:4WU9 [DatabaseIdentifier:12178116] PDB:4QEO [DatabaseIdentifier:12165954] PDB:7KBD [DatabaseIdentifier:12165989] PDB:9E1Q [DatabaseIdentifier:12165976] PDB:8VX6 [DatabaseIdentifier:12165947] PDB:8OF4 [DatabaseIdentifier:12141495] PDB:8HY0 [DatabaseIdentifier:12166004] PDB:8CBN [DatabaseIdentifier:12160209] PDB:6T9L [DatabaseIdentifier:12178119] PDB:5MLU [DatabaseIdentifier:12165948] PDB:3O62 [DatabaseIdentifier:12165971] PDB:8G86 [DatabaseIdentifier:12141986] PDB:6OM3 [DatabaseIdentifier:12165959] PDB:5X0X [DatabaseIdentifier:12165982] PDB:9E1V [DatabaseIdentifier:12141476] PDB:8HXX [DatabaseIdentifier:12165934] PDB:6R1T [DatabaseIdentifier:12165991] PDB:9E1R [DatabaseIdentifier:12165936] PDB:9GD2 [DatabaseIdentifier:12165986] PDB:9E1M [DatabaseIdentifier:12165933] PDB:9GD1 [DatabaseIdentifier:12165984] PDB:9E1O [DatabaseIdentifier:12165978] PDB:9E1W [DatabaseIdentifier:12163597] PDB:6IRO [DatabaseIdentifier:12159950] PDB:8G6H [DatabaseIdentifier:12145613] PDB:7ZSB [DatabaseIdentifier:12147007] PDB:8B0A [DatabaseIdentifier:12165975] PDB:8V6V [DatabaseIdentifier:12165950] PDB:7KBF [DatabaseIdentifier:12159949] PDB:8G6G [DatabaseIdentifier:12165953] PDB:4J8V [DatabaseIdentifier:12165963] PDB:6R1U [DatabaseIdentifier:12139346] PDB:6KW5 [DatabaseIdentifier:12139347] PDB:6KW4 [DatabaseIdentifier:12165961] PDB:5X0Y [DatabaseIdentifier:12159948] PDB:8G6S [DatabaseIdentifier:12145617] PDB:7ZSA [DatabaseIdentifier:12155238] PDB:7E8I [DatabaseIdentifier:12165969] PDB:8G88 [DatabaseIdentifier:12165999] PDB:8CBQ [DatabaseIdentifier:12178117] PDB:2IO5 [DatabaseIdentifier:12165958] PDB:4R8P [DatabaseIdentifier:12159930] PDB:6UH5 [DatabaseIdentifier:12165981] PDB:7KTQ [DatabaseIdentifier:12139345] PDB:6KW3 [DatabaseIdentifier:12165973] PDB:1ZBB [DatabaseIdentifier:12165949] PDB:4XUJ [DatabaseIdentifier:12165940] PDB:5Z3O [DatabaseIdentifier:12165955] PDB:4J8W [DatabaseIdentifier:12165935] PDB:6R25 [DatabaseIdentifier:12165932] PDB:9GD0 [DatabaseIdentifier:12165962] PDB:1S32 [DatabaseIdentifier:12141102] PDB:6PA7 [DatabaseIdentifier:12165965] PDB:8G8G [DatabaseIdentifier:12166000] PDB:1KX4 [DatabaseIdentifier:12159945] PDB:8G6Q [DatabaseIdentifier:12159937] PDB:6NJ9 [DatabaseIdentifier:12178114] PDB:3GV6 [DatabaseIdentifier:12165945] PDB:5Z3U [DatabaseIdentifier:12165995] PDB:4WU8 [DatabaseIdentifier:12165941] PDB:7VVZ [DatabaseIdentifier:12166001] PDB:1KX3 [DatabaseIdentifier:12165974] PDB:8VX5 [DatabaseIdentifier:12157784] PDB:5KGF [DatabaseIdentifier:12165990] PDB:3UTA [DatabaseIdentifier:12165985] PDB:9E1P [DatabaseIdentifier:12160154] PDB:6WKR [DatabaseIdentifier:12178118] PDB:5XBK [DatabaseIdentifier:12165951] PDB:7EG6 [DatabaseIdentifier:12165952] PDB:4J8U [DatabaseIdentifier:12139344] PDB:6UXW [DatabaseIdentifier:12178115] PDB:4EO5 [DatabaseIdentifier:12165983] PDB:9E1Y [DatabaseIdentifier:12165937] PDB:9GD3 [DatabaseIdentifier:12165186] PDB:8TAS [DatabaseIdentifier:12165992] PDB:8EUJ [DatabaseIdentifier:12165987] PDB:9E1N [DatabaseIdentifier:12165977] PDB:3UTB [DatabaseIdentifier:12166002] PDB:8T3T [DatabaseIdentifier:12165176] PDB:8TB9 [DatabaseIdentifier:12165996] PDB:3UT9 [DatabaseIdentifier:12166003] PDB:8V7L [DatabaseIdentifier:12165942] PDB:5ONW [DatabaseIdentifier:12141477] PDB:8HXY [DatabaseIdentifier:12165970] PDB:8ETT [DatabaseIdentifier:12165938] PDB:5Z3V [DatabaseIdentifier:12165972] PDB:8V4Y [DatabaseIdentifier:12141474] PDB:8HXZ [DatabaseIdentifier:12158749] PDB:7SSA [DatabaseIdentifier:12165957] PDB:4J8X [DatabaseIdentifier:12165968] PDB:8ETV [DatabaseIdentifier:12165993] PDB:2F8N [DatabaseIdentifier:12165979] PDB:9E1X [DatabaseIdentifier:12165964] PDB:8G8B [DatabaseIdentifier:12139348] PDB:7EGP [DatabaseIdentifier:12165966] PDB:8EUE [DatabaseIdentifier:12165980] PDB:9E1U [DatabaseIdentifier:12165998] PDB:1KX5
databaseName	UniProt
dbId	4549225
description	recommendedName: Histone H3.2
displayName	UniProt:P84233 Unknown
identifier	P84233
isSequenceChanged	false
keyword	3D-structure Acetylation ADP-ribosylation Chromosome Citrullination DNA-binding Hydroxylation Isopeptide bond Lipoprotein Methylation Nucleosome core Nucleus Palmitate Phosphoprotein Reference proteome Ubl conjugation
modified	[InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType	Protein
name	Histone H3.2
physicalEntity	[EntityWithAccessionedSequence:R-XLA-4549227] Histone H3.2 [nucleoplasm] - Xenopus laevis [EntityWithAccessionedSequence:R-XLA-4549248] Ack15-histone H3.2 [nucleoplasm] - Xenopus laevis
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12008013] Monarch:121399124 [ReferenceDNASequence:12711068] UCSC:P84233 [ReferenceDNASequence:12092100] NCBI Gene:108704296 [ReferenceDNASequence:12092098] NCBI Gene:121394151 [ReferenceDNASequence:12092107] NCBI Gene:108716540 [ReferenceDNASequence:12092102] NCBI Gene:108695575 [ReferenceDNASequence:12092097] NCBI Gene:121399123 [ReferenceDNASequence:12092103] NCBI Gene:108704298 [ReferenceDNASequence:12092106] NCBI Gene:121399124 [ReferenceDNASequence:12092104] NCBI Gene:121402225 [ReferenceDNASequence:12092108] NCBI Gene:121393613 [ReferenceDNASequence:12092099] NCBI Gene:121398066 [ReferenceDNASequence:12092101] NCBI Gene:108705672 [ReferenceDNASequence:12092105] NCBI Gene:108716541 [ReferenceDNASequence:12092096] NCBI Gene:121398064 [ReferenceDNASequence:12008008] Monarch:108705672 [ReferenceDNASequence:12008003] Monarch:121398064 [ReferenceDNASequence:12008007] Monarch:108704296 [ReferenceDNASequence:11378224] BioGPS Gene:121399124 [ReferenceDNASequence:11378215] BioGPS Gene:121399123 [ReferenceDNASequence:11378222] BioGPS Gene:121402225 [ReferenceDNASequence:11378221] BioGPS Gene:108704298 [ReferenceDNASequence:11378220] BioGPS Gene:108695575 [ReferenceDNASequence:11378218] BioGPS Gene:108704296 [ReferenceDNASequence:11378216] BioGPS Gene:121394151 [ReferenceDNASequence:11378226] BioGPS Gene:121393613 [ReferenceDNASequence:11378214] BioGPS Gene:121398064 [ReferenceDNASequence:11378217] BioGPS Gene:121398066 [ReferenceDNASequence:11378219] BioGPS Gene:108705672 [ReferenceDNASequence:11378223] BioGPS Gene:108716541 [ReferenceDNASequence:11378225] BioGPS Gene:108716540 [ReferenceDNASequence:11915518] KEGG:xla:108716540 [ReferenceDNASequence:11915516] KEGG:xla:121398066 [ReferenceDNASequence:11915507] KEGG:xla:121393613 [ReferenceDNASequence:11915510] KEGG:xla:121398064 [ReferenceDNASequence:11915513] KEGG:xla:121399123 [ReferenceDNASequence:11915517] KEGG:xla:108695575 [ReferenceDNASequence:11915512] KEGG:xla:108705672 [ReferenceDNASequence:11915519] KEGG:xla:108716541 [ReferenceDNASequence:11915509] KEGG:xla:108704298 [ReferenceDNASequence:11915514] KEGG:xla:121399124 [ReferenceDNASequence:11915515] KEGG:xla:121394151 [ReferenceDNASequence:11915508] KEGG:xla:121402225 [ReferenceDNASequence:11915511] KEGG:xla:108704296 [ReferenceDNASequence:12008009] Monarch:108695575 [ReferenceDNASequence:12008010] Monarch:108704298 [ReferenceDNASequence:12008005] Monarch:121394151 [ReferenceDNASequence:12008012] Monarch:108716541 [ReferenceDNASequence:12008011] Monarch:121402225 [ReferenceDNASequence:12008006] Monarch:121398066 [ReferenceDNASequence:12008004] Monarch:121399123 [ReferenceDNASequence:12008014] Monarch:108716540 [ReferenceDNASequence:12008015] Monarch:121393613
referenceTranscript	[ReferenceRNASequence:12637641] RefSeq:XM_018240807.2 [ReferenceRNASequence:12637644] RefSeq:XM_041579065.1 [ReferenceRNASequence:12637645] RefSeq:XM_041579064.1 [ReferenceRNASequence:12637638] RefSeq:XM_018262738.2 [ReferenceRNASequence:12637643] RefSeq:XM_041576616.1 [ReferenceRNASequence:12637642] RefSeq:XM_041564193.1 [ReferenceRNASequence:12637640] RefSeq:XM_018262737.2 [ReferenceRNASequence:12637647] RefSeq:XM_018242547.2 [ReferenceRNASequence:12637636] RefSeq:XM_018224168.2 [ReferenceRNASequence:12637637] RefSeq:XM_041588822.1 [ReferenceRNASequence:12637646] RefSeq:XM_041579063.1 [ReferenceRNASequence:12637639] RefSeq:XM_041576614.1 [ReferenceRNASequence:12637648] RefSeq:XM_041562606.1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	H32_XENLA A4FVE2 P02295 P02297 P16105 P17269 P17320
sequenceLength	136
species	[Species:51320] Xenopus laevis
stId	uniprot:P84233
url	http://purl.uniprot.org/uniprot/P84233

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-XLA-4549227] Histone H3.2 [nucleoplasm] [EntityWithAccessionedSequence:R-XLA-4549248] Ack15-histone H3.2 [nucleoplasm]
(referenceSequence)	[ModifiedResidue:4549244] N6-acetyl-L-lysine at 15
(interactor)	[UndirectedInteraction:11164547] UniProt:P84233 <-> UniProt:P02281 (IntAct) [UndirectedInteraction:11164551] UniProt:P84233 <-> UniProt:P06897 (IntAct) [UndirectedInteraction:11164555] UniProt:P84233 <-> UniProt:C0H4U4 (IntAct) [UndirectedInteraction:11164557] UniProt:P84233 <-> UniProt:P0C0S8 (IntAct) [UndirectedInteraction:11164559] UniProt:P84233 <-> UniProt:Q9Y294 (IntAct) [UndirectedInteraction:11164561] UniProt:P84233 <-> UniProt:P32447 (IntAct) [UndirectedInteraction:11164563] UniProt:P84233 <-> UniProt:P62799 (IntAct) [UndirectedInteraction:11164565] UniProt:P84233 <-> UniProt:P32657 (IntAct)

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