UniProt:P83916 CBX1

chain
  • chain:1-185
checksum BE687AF9C66E48E3
comment
  • FUNCTION Component of heterochromatin, which recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression (By similarity). Also recognizes and binds histone H1.4 methylated at 'Lys-26' (H1.4K26me) (PubMed:16127177). Excluded from chromatin when histone H1.4 is Simultaneously methylated at Lys-26 (H1.4K26me) and phosphorylated at Ser-27 (H1.4S27Ph) (PubMed:16127177). Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane (By similarity).SUBUNIT Homodimer (By similarity). Interacts directly with CHAF1A, EMSY, LBR, TIF1/TIF1A and TRIM28/TIF1B PXVXL motif via the chromoshadow domain (PubMed:14651845, PubMed:16615912). Interacts directly with histone H3 methylated at 'Lys-9' via the chromo domain (By similarity). Interacts with SUV39H1 and SETDB1, KMT5B and KMT5C (PubMed:10202156, PubMed:15899859). Interacts with PRDM6 (By similarity). Interacts with POGZ (PubMed:20562864, PubMed:20850016). Interacts with CHAMP1 (PubMed:20850016). Interacts with INCENP (PubMed:21346195). Interacts with SGO1; the CBX1 homodimer binds to one molecule of SGO1 (PubMed:21346195). Interacts with LRIF1 (via PxVxL motif) (PubMed:23542155). Interacts with HDGFL2 (PubMed:26721387). Interacts with CHD3 (PubMed:28977666). Interacts with CHD4 (PubMed:28977666).INTERACTION Unassociated with chromosomes during mitosis.TISSUE SPECIFICITY Expressed in all adult and embryonic tissues.PTM Not phosphorylated.PTM Ubiquitinated.CAUTION Was previously reported to interact with ASXL1. However, this publication has been retracted.ONLINE INFORMATION Heterochromatin protein 1 entry
crossReference
databaseName UniProt
dbId 51514
description
  • recommendedName: Chromobox protein homolog 1 alternativeName: HP1Hsbeta alternativeName: Heterochromatin protein 1 homolog beta shortName: HP1 beta alternativeName: Heterochromatin protein p25 alternativeName: M31 alternativeName: Modifier 1 protein alternativeName: p25beta
displayName UniProt:P83916 CBX1
geneName
  • CBX1
  • CBX
identifier P83916
isSequenceChanged false
keyword
  • 3D-structure
  • Direct protein sequencing
  • Isopeptide bond
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Ubl conjugation
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • CBX1
otherIdentifier
  • 10951
  • 11715546_s_at
  • 16846181
  • 201518_PM_at
  • 201518_at
  • 37304_at
  • 3761126
  • 3761128
  • 3761129
  • 3761130
  • 3761132
  • 3761133
  • 3761134
  • 3761135
  • 3761138
  • 3761139
  • 3761140
  • 3761141
  • 4010449
  • 4010450
  • 4010451
  • 8016402
  • A_23_P107507
  • A_24_P296568
  • GE59106
  • GO:0000775
  • GO:0000781
  • GO:0000785
  • GO:0000792
  • GO:0001939
  • GO:0001940
  • GO:0003682
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005721
  • GO:0005819
  • GO:0006325
  • GO:0006355
  • GO:0006974
  • GO:0010369
  • GO:0016604
  • GO:0019899
  • GO:0031507
  • GO:0042802
  • GO:0043226
  • GO:0045892
  • GO:0090734
  • GO:1990226
  • HMNXSV003030618
  • ILMN_1770244
  • PH_hs_0027694
  • TC17001635.hg
  • U35451_at
  • g5803075_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • CBX1_HUMAN
  • P23197
sequenceLength 185
species [Species:48887] Homo sapiens
stId uniprot:P83916
url http://purl.uniprot.org/uniprot/P83916

Referrals

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