UniProt:P82251 SLC7A9

chain
  • chain:1-487
checksum EF2C30DDE15594F1
comment
  • FUNCTION Associates with SLC3A1 to form a functional transporter complex that mediates the electrogenic exchange between cationic amino acids and neutral amino acids, with a stoichiometry of 1:1 (PubMed:16825196, PubMed:32494597, PubMed:32817565, PubMed:8663357). Has system b(0,+)-like activity with high affinity for extracellular cationic amino acids and L-cystine and lower affinity for intracellular neutral amino acids (PubMed:16825196, PubMed:32494597, PubMed:8663357). Substrate exchange is driven by high concentration of intracellular neutral amino acids and the intracellular reduction of L-cystine to L-cysteine (PubMed:8663357). Required for reabsorption of L-cystine and dibasic amino acids across the brush border membrane in renal proximal tubules.CATALYTIC ACTIVITY L-leucine(out) + L-arginine(in) = L-leucine(in) + L-arginine(out)CATALYTIC ACTIVITY L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)CATALYTIC ACTIVITY L-phenylalanine(out) + L-arginine(in) = L-phenylalanine(in) + L-arginine(out)CATALYTIC ACTIVITY L-cysteine(out) + L-arginine(in) = L-cysteine(in) + L-arginine(out)CATALYTIC ACTIVITY L-cystine(out) + L-arginine(in) = L-cystine(in) + L-arginine(out)CATALYTIC ACTIVITY L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)BIOPHYSICOCHEMICAL PROPERTIES Disulfide-linked heterodimer composed of the catalytic light chain subunit SLC7A9 and the heavy chain subunit SLC3A1. The heterodimer is the minimal functional unit. Assembles in heterotetramers (dimers of heterodimers) and higher order oligomers; the oligomerization is mediated by SLC3A1 likely to prevent degradation and facilitate heteromer trafficking to the plasma membrane (PubMed:16825196, PubMed:32494597, PubMed:32817565). Interacts with CAV1 (By similarity).INTERACTION Expressed in the brush border membrane in the kidney (at protein level). Kidney, small intestine, liver and placenta.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the amino acid-polyamine-organocation (APC) superfamily.
crossReference
databaseName UniProt
dbId 50703
description
  • recommendedName: b(0,+)-type amino acid transporter 1 shortName: b(0,+)AT1 alternativeName: Glycoprotein-associated amino acid transporter b0,+AT1 alternativeName: Solute carrier family 7 member 9
displayName UniProt:P82251 SLC7A9
geneName
  • SLC7A9
  • BAT1
identifier P82251
isSequenceChanged false
keyword
  • 3D-structure
  • Amino-acid transport
  • Cell membrane
  • Cystinuria
  • Disease variant
  • Disulfide bond
  • Membrane
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Transmembrane
  • Transmembrane helix
  • Transport
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • SLC7A9
otherIdentifier
  • 11136
  • 11726940_a_at
  • 16871161
  • 220135_PM_s_at
  • 220135_s_at
  • 3858758
  • 3858759
  • 3858765
  • 3858766
  • 3858767
  • 3858768
  • 3858770
  • 3858772
  • 3858773
  • 3858774
  • 3858775
  • 3858776
  • 3858778
  • 3858779
  • 3858782
  • 3858783
  • 3858784
  • 3858786
  • 3858787
  • 3858788
  • 3858790
  • 8035941
  • 89096_at
  • A_23_P142250
  • GE62493
  • GO:0003333
  • GO:0005515
  • GO:0005886
  • GO:0006865
  • GO:0015171
  • GO:0015175
  • GO:0015184
  • GO:0015297
  • GO:0015804
  • GO:0015811
  • GO:0016020
  • GO:0016324
  • GO:0022857
  • GO:0031526
  • GO:0042605
  • GO:0046982
  • GO:0055085
  • GO:0065003
  • GO:0180009
  • GO:1902475
  • GO:1990822
  • HMNXSV003048161
  • ILMN_1735445
  • PH_hs_0033197
  • TC19001390.hg
  • g7657590_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • BAT1_HUMAN
  • B2R9A6
sequenceLength 487
species [Species:48887] Homo sapiens
stId uniprot:P82251
url http://purl.uniprot.org/uniprot/P82251
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