UniProt:P80217 IFI35

chain
  • initiator methionine:1
  • chain:2-286
checksum 3FCAB26E97317508
comment
  • FUNCTION Acts as a signaling pathway regulator involved in innate immune system response (PubMed:26342464, PubMed:29038465, PubMed:29350881). In response to interferon IFN-alpha, associates in a complex with signaling pathway regulator NMI to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 and correlates with IFI35 dephosphorylation (PubMed:10779520, PubMed:10950963). In complex with NMI, inhibits virus-triggered type I interferon/IFN-beta production (PubMed:26342464). In complex with NMI, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of the NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries (PubMed:29350881). Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation when actively released by macrophage to the extracellular space during cell injury and pathogen invasion (PubMed:29038465). Macrophage-secreted IFI35 activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of pro-inflammatory cytokines (PubMed:29038465).SUBUNIT Homodimer (PubMed:10950963, PubMed:8288566). Also interacts with BATF (PubMed:8954125). Interacts with TRIM21 (PubMed:26342464). Interacts with NMI; the interaction is direct and is facilitated by TRIM21 (PubMed:10779520, PubMed:10950963, PubMed:26342464).INTERACTION Cytoplasmic IFI35 localizes in punctate granular structures (PubMed:10950963). Nuclear localization increased is stimulated by IFN-alpha (PubMed:10950963, PubMed:8288566). Extracelullar following secretion by macrophage (PubMed:29038465).ALTERNATIVE PRODUCTS Expressed in a wide range of cell types, including fibroblasts, macrophages, and epithelial cells.INDUCTION Up-regulated by interferons IFN-alpha and IFN-gamma.DOMAIN The NID domain 1 is involved in the negative regulation of p65/RELA transcription and the negative regulation of NF-kappa-B pathway activation.PTM Phosphorylated. Dephosphorylation correlates with the formation of a complex with NMI.MISCELLANEOUS Due to a polymorphism at the 3'-splice acceptor site of intron 4.SIMILARITY Belongs to the NMI family.SEQUENCE CAUTION Contaminating sequence. Sequence of unknown origin in the N-terminal part.
crossReference
databaseName UniProt
dbId 57353
description
  • recommendedName: fullName evidence="15"Interferon-induced 35 kDa protein shortName evidence="13 15"IFP 35 shortName evidence="12 14"Ifi-35
displayName UniProt:P80217 IFI35
geneName
  • IFI35
  • IFP35
identifier P80217
isSequenceChanged false
keyword
  • Alternative splicing
  • Cytoplasm
  • Direct protein sequencing
  • Immunity
  • Innate immunity
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Secreted
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • IFI35
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • IN35_HUMAN
  • C9JGX1
  • Q92984
  • Q99537
  • Q9BV98
sequenceLength 286
species [Species:48887] Homo sapiens
stId uniprot:P80217
url http://purl.uniprot.org/uniprot/P80217
Cite Us!