UniProt:P79996 MAPK9

chain
  • chain:1-382
checksum 9A737C925465E54C
comment
  • FUNCTION Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity (By similarity). May play a role in the development of the central nervous system during embryogenesis. May play a role in the regulation of the circadian clock (By similarity).CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)COFACTOR Activated by threonine and tyrosine phosphorylation.TISSUE SPECIFICITY Expressed in the neuroepithelium of developing brain at stages 16 to 26.DOMAIN The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.PTM Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme.SIMILARITY Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
created [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18
crossReference
databaseName UniProt
dbId 394028
description
  • recommendedName: Mitogen-activated protein kinase 9 shortName: MAP kinase 9 shortName: MAPK 9 ecNumber: 2.7.11.24 alternativeName: Stress-activated protein kinase JNK2 alternativeName: c-Jun N-terminal kinase 2
displayName UniProt:P79996 MAPK9
geneName
  • MAPK9
  • JNK2
identifier P79996
isSequenceChanged false
keyword
  • ATP-binding
  • Biological rhythms
  • Kinase
  • Nucleotide-binding
  • Phosphoprotein
  • Reference proteome
  • Serine/threonine-protein kinase
  • Transferase
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • MAPK9
otherIdentifier
  • 395983
  • GO:0000165
  • GO:0000166
  • GO:0003824
  • GO:0004672
  • GO:0004674
  • GO:0004705
  • GO:0004707
  • GO:0004712
  • GO:0005524
  • GO:0005634
  • GO:0005737
  • GO:0005739
  • GO:0005829
  • GO:0005886
  • GO:0006468
  • GO:0006954
  • GO:0007254
  • GO:0009792
  • GO:0010628
  • GO:0010744
  • GO:0016301
  • GO:0016607
  • GO:0016740
  • GO:0031398
  • GO:0032436
  • GO:0034614
  • GO:0042752
  • GO:0043488
  • GO:0046686
  • GO:0048511
  • GO:0048856
  • GO:0050804
  • GO:0061157
  • GO:0061833
  • GO:0071803
  • GO:0090594
  • GO:0097190
  • GO:0098685
  • GO:0106310
  • GO:0140096
  • GO:1900017
  • GO:2001235
  • GT_A_87_P012972
  • GT_A_87_P038229
  • GT_A_87_P146168
  • GT_Sp_Chicken_CO761476_7299
  • Gga.19487.1.S1_s_at
  • Gga.3651.1.S1_at
  • Gga.5011.1.S1_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • MK09_CHICK
sequenceLength 382
species [Species:49591] Gallus gallus
stId uniprot:P79996
url http://purl.uniprot.org/uniprot/P79996
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