UniProt:P78545 ELF3

chain
  • chain:1-371
checksum 81A23A7DECBE2EF9
comment
  • FUNCTION Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity).SUBUNIT Interacts with TBP. Interacts with CREBBP and EP300; these act as transcriptional coactivators of ELF3 and positively modulate its function. Interacts with XRCC5/KU86 and XRCC6/KU70; these inhibit the ability of ELF3 to bind DNA and negatively modulate its transcriptional activity. Associated with CLND7 and POU2F3. Interacts with ZNF768 (PubMed:30476274).INTERACTION Localizes to the cytoplasm where it has been shown to transform MCF-12A mammary epithelial cells via a novel cytoplasmic mechanism. Also transiently expressed and localized to the nucleus where it induces apoptosis in non-transformed breast epithelial cells MCF-10A and MCF-12A via a transcription-dependent mechanism.ALTERNATIVE PRODUCTS Additional isoforms may exist.TISSUE SPECIFICITY Expressed exclusively in tissues containing a high content of terminally differentiated epithelial cells including mammary gland, colon, trachea, kidney, prostate, uterus, stomach and skin.INDUCTION Transcriptionally regulated by ERBB2 receptor signaling in breast cancer epithelial cells. Up-regulated by phorbol 12-myristate 13-acetate (PMA) in bronchial epithelial cells. By retinoic acid in MCF-7 mammary epithelial cells (at protein level).DOMAIN The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.SIMILARITY Belongs to the ETS family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 228149
description
  • recommendedName: ETS-related transcription factor Elf-3 alternativeName: E74-like factor 3 alternativeName: Epithelial-restricted with serine box alternativeName: Epithelium-restricted Ets protein ESX alternativeName: Epithelium-specific Ets transcription factor 1 shortName: ESE-1
displayName UniProt:P78545 ELF3
geneName
  • ELF3
  • ERT
  • ESX
  • JEN
identifier P78545
isSequenceChanged false
keyword
  • 3D-structure
  • Activator
  • Alternative splicing
  • Cytoplasm
  • Developmental protein
  • Differentiation
  • DNA-binding
  • Inflammatory response
  • Nucleus
  • Proteomics identification
  • Reference proteome
  • Repressor
  • Transcription
  • Transcription regulation
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • ELF3
otherIdentifier
  • 11717594_s_at
  • 11717595_s_at
  • 11751914_s_at
  • 11755315_a_at
  • 16675924
  • 1999
  • 201003_PM_x_at
  • 201003_x_at
  • 201510_PM_at
  • 201510_at
  • 208270_PM_s_at
  • 208270_s_at
  • 210827_PM_s_at
  • 210827_s_at
  • 229842_PM_at
  • 229842_at
  • 2375008
  • 2375009
  • 2375010
  • 2375012
  • 2375013
  • 2375014
  • 2375015
  • 2375016
  • 2375017
  • 2375018
  • 2375020
  • 2375021
  • 2375022
  • 2375023
  • 2375024
  • 2375025
  • 2375026
  • 2375027
  • 2375028
  • 2375029
  • 2375030
  • 2375031
  • 2375033
  • 2375034
  • 2375035
  • 2375036
  • 2375037
  • 36959_at
  • 40445_at
  • 62536_at
  • 78130_at
  • 7908793
  • 80594_at
  • 86807_at
  • A_23_P104188
  • A_33_P3258091
  • GE80150
  • GO:0000785
  • GO:0000978
  • GO:0000981
  • GO:0001228
  • GO:0001824
  • GO:0003677
  • GO:0003700
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005737
  • GO:0005794
  • GO:0005829
  • GO:0006355
  • GO:0006357
  • GO:0006954
  • GO:0009653
  • GO:0030154
  • GO:0030198
  • GO:0043565
  • GO:0045892
  • GO:0045944
  • GO:0048856
  • GO:0060056
  • GO:1990837
  • HMNXSV003038978
  • HMNXSV003043209
  • HMNXSV003058243
  • Hs.67928.0.A1_3p_at
  • ILMN_1738347
  • ILMN_1769201
  • PH_hs_0014660
  • PH_hs_0031289
  • TC01001670.hg
  • U49278_at
  • U73843_at
  • g12025659_3p_s_at
  • g1841524_3p_a_at
  • g2338755_3p_at
  • p33365
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • ELF3_HUMAN
  • B2R5Q6
  • Q6IAP8
  • Q7RU03
  • Q7Z3X2
  • Q8NFG2
  • Q99718
sequenceLength 371
species [Species:48887] Homo sapiens
stId uniprot:P78545
url http://purl.uniprot.org/uniprot/P78545
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