UniProt:P78537 BLOC1S1

chain
  • chain:1-153
checksum B7D1FE64F242B25A
comment
  • FUNCTION Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes (PubMed:17182842). In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (PubMed:17182842). The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (PubMed:17182842). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery (PubMed:25898167). Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167).FUNCTION Acts as a protein acetyltransferase (PubMed:22309213, PubMed:38281616). Negatively regulates aerobic respiration through mitochondrial protein lysine-acetylation (PubMed:22309213). May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9 (PubMed:22309213). Acts as a regulator of mTORC2 signaling in response to hypotoxic stress by mediating acetylation of RICTOR, thereby protecting RICTOR against ubiquitination and subsequent degradation by the proteasome (PubMed:38281616).CATALYTIC ACTIVITY L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)SUBUNIT Component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) composed of BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8 (PubMed:15102850, PubMed:22203680). Octamer composed of one copy each BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8 (PubMed:15102850, PubMed:22203680). The BLOC-1 complex associates with the AP-3 protein complex and membrane protein cargos (By similarity). Component of the BLOC-one-related complex (BORC) which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN (PubMed:25898167). Interacts with ATP5F1A and NDUFA9; involved in their acetylation on lysine residues (PubMed:22309213). Interacts with KXD1 (By similarity).INTERACTION May be produced by alternative initiation at Met-27 of isoform 1. A polymorphism at position 9 leads to the creation of a stop codon. Isoform 2 is the only form that exists in orthologs (except primates).SIMILARITY Belongs to the BLOC1S1 family.SEQUENCE CAUTION Truncated N-terminus.
crossReference
databaseName UniProt
dbId 55476
description
  • recommendedName: Biogenesis of lysosome-related organelles complex 1 subunit 1 shortName: BLOC-1 subunit 1 alternativeName: fullName evidence="11"GCN5-like protein 1 alternativeName: Protein RT14 alternativeName: fullName evidence="13"Protein acetyltransferase BLOC1S1 ecNumber evidence="15"2.3.1.-
displayName UniProt:P78537 BLOC1S1
geneName
  • BLOC1S1
  • BLOS1
  • GCN5L1
  • RT14
identifier P78537
isSequenceChanged false
keyword
  • Alternative initiation
  • Coiled coil
  • Cytoplasm
  • Lysosome
  • Membrane
  • Mitochondrion
  • Proteomics identification
  • Reference proteome
  • Transferase
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • BLOC1S1
otherIdentifier
  • 11716289_a_at
  • 202592_PM_at
  • 202592_at
  • 236291_PM_at
  • 236291_at
  • 2647
  • 3416910
  • 3416911
  • 3416912
  • 3416914
  • 3416915
  • 3416917
  • 3416918
  • 3416919
  • 3416920
  • 3416922
  • 3416923
  • 39133_at
  • 7956013
  • 87407_at
  • A_23_P53298
  • A_33_P3388870
  • GE57286
  • GO:0003824
  • GO:0005515
  • GO:0005615
  • GO:0005737
  • GO:0005739
  • GO:0005758
  • GO:0005759
  • GO:0005764
  • GO:0005765
  • GO:0005768
  • GO:0005769
  • GO:0005829
  • GO:0007018
  • GO:0008089
  • GO:0009060
  • GO:0016020
  • GO:0016192
  • GO:0016197
  • GO:0016740
  • GO:0018394
  • GO:0031083
  • GO:0031175
  • GO:0032418
  • GO:0032438
  • GO:0048490
  • GO:0051036
  • GO:0060155
  • GO:0061733
  • GO:0062196
  • GO:0072384
  • GO:0098574
  • GO:0099078
  • GO:0140096
  • GO:1904115
  • HMNXSV003032443
  • HMNXSV003032470
  • Hs.222853.0.S1_3p_at
  • ILMN_2157510
  • PH_hs_0005179
  • S82447_s_at
  • TC12002384.hg
  • TC12003299.hg
  • g4503954_3p_at
  • p24922
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • BL1S1_HUMAN
  • A1L4Q9
  • Q6NZ45
sequenceLength 153
species [Species:48887] Homo sapiens
stId uniprot:P78537
url http://purl.uniprot.org/uniprot/P78537
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