UniProt:P70662 Ldb1

chain
  • initiator methionine:1
  • chain:2-411
checksum 47C53DFA23044580
comment
  • FUNCTION Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors (PubMed:8918878, PubMed:9192866). May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions (PubMed:16815859, PubMed:18539116, PubMed:8918878, PubMed:9192866, PubMed:9315627). Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1 (PubMed:12150931, PubMed:18539116, PubMed:8876198). Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression (PubMed:8918878). Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (PubMed:9391090).SUBUNIT Interacts with ESR1 (By similarity). Forms homodimers and heterodimers (PubMed:9315627, PubMed:9468533). Interacts with and activates LHX1/LIM1 (PubMed:8918878, PubMed:9468533). Interacts with the LIM domains of ISL1 and LMO2 (PubMed:12150931, PubMed:12727888). Can assemble in a complex with LMO2 and TAL1/SCL but does not interact with TAL1/SCL directly (PubMed:9391090). Strongly interacts with the LIM2 domain of LMX1A and more weakly with the LIM1 domain (PubMed:9315627). Homodimerization is not required for, and does not effect, LMX1A-binding (PubMed:9315627). Component of a nuclear TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3 (PubMed:16407974). Interacts with LHX6 and LHX9 (PubMed:10330499, PubMed:10393337). At neuronal promoters, forms a complex with LHX3 involved in the specification of interneurons, in motor neurons, it is displaced by ISL1 to form a ternary complex in which ISL1 contacts both LHX3 and LDB1 (PubMed:12150931, PubMed:18539116). Interacts with SLK; leading to negatively regulate SLK kinase activity (PubMed:19675209). Interacts with YWHAZ (By similarity). Interacts with PRDM1/BLIMP1 (By similarity). Interacts with LMO4 (PubMed:15343268, PubMed:23353824, PubMed:9860983). Interacts with RLIM/RNF12; the interaction inhibits the ubiquitination of LMO proteins (PubMed:11882901).INTERACTION Colocalizes with SLK at leading edges (PubMed:19675209).ALTERNATIVE PRODUCTS Expressed in multiple adult tissues including heart, brain, liver, kidney, testis, lung and muscle, with expression highest in the pituitary gland and skin.DEVELOPMENTAL STAGE Expression in the embryo overlaps that of LIM domain-containing proteins (PubMed:9192866). Expressed widely in the embryo with highest expression in several regions of the brain, and the central nervous system ganglia (PubMed:8918878, PubMed:9192866, PubMed:9391090). Also expressed in fetal liver, lung, kidney, thymus and olfactory epithelium (PubMed:16815859, PubMed:9192866, PubMed:9391090). Expressed in, but not restricted to, the basal compartment of interfollicular epidermis, the developing hair follicles during embryogenesis and, in adult hair, expressed in matrix cells and the outer root sheath (PubMed:9860983). Expressed in both embryonic and adult hemopoietic cells, including the erythroid lineage (PubMed:9391090).DOMAIN The dimerization domain is located in the N-terminus.PTM Ubiquitinated by RLIM/RNF12, leading to its degradation by the proteasome.MISCELLANEOUS Due to intron retention. Lacks LIM-binding domain. Lacks ability to activate LIM domain-dependent transcription.SIMILARITY Belongs to the LDB family.
crossReference
databaseName UniProt
dbId 94328
description
  • recommendedName: LIM domain-binding protein 1 shortName: LDB-1 alternativeName: Carboxyl-terminal LIM domain-binding protein 2 shortName: CLIM-2 alternativeName: LIM domain-binding factor CLIM2 shortName: mLdb1 alternativeName: Nuclear LIM interactor
displayName UniProt:P70662 Ldb1
geneName
  • Ldb1
  • Nli
identifier P70662
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Alternative splicing
  • Developmental protein
  • Nucleus
  • Phosphoprotein
  • Reference proteome
  • Ubl conjugation
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • Ldb1
otherIdentifier
  • 10468159
  • 1452024_a_at
  • 160498_at
  • 16825
  • 17365314
  • 4403269
  • 4427395
  • 4580767
  • 4585584
  • 4695999
  • 4784150
  • 4850444
  • 4880880
  • 4890943
  • 4902097
  • 4926531
  • 4928353
  • 5152848
  • 5209512
  • 5267246
  • 5400518
  • 5590740
  • A_51_P384754
  • A_51_P384756
  • A_66_P135769
  • GE35676
  • GO:0000122
  • GO:0000785
  • GO:0000972
  • GO:0001702
  • GO:0001942
  • GO:0003677
  • GO:0003682
  • GO:0003712
  • GO:0003713
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005667
  • GO:0006351
  • GO:0006355
  • GO:0006366
  • GO:0007155
  • GO:0007399
  • GO:0009948
  • GO:0010669
  • GO:0016055
  • GO:0019899
  • GO:0021549
  • GO:0021702
  • GO:0030154
  • GO:0030182
  • GO:0030274
  • GO:0030334
  • GO:0031252
  • GO:0032968
  • GO:0032991
  • GO:0035019
  • GO:0042802
  • GO:0042803
  • GO:0043549
  • GO:0045647
  • GO:0045785
  • GO:0045892
  • GO:0045944
  • GO:0046985
  • GO:0048856
  • GO:0051893
  • GO:0060319
  • GO:0060322
  • GO:0061629
  • GO:0090575
  • GO:0140297
  • GO:1990907
  • ILMN_2601907
  • mMC006995
  • u69270_s_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • LDB1_MOUSE
  • O55204
  • Q1EQX2
  • Q71V68
sequenceLength 411
species [Species:48892] Mus musculus
stId uniprot:P70662
url http://purl.uniprot.org/uniprot/P70662
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